DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and trim32

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001096393.1	Gene:	trim32 / 100124994	XenbaseID:	XB-GENE-1011959	Length:	649	Species:	Xenopus tropicalis

Alignment Length:	687	Identity:	127/687 - (18%)
Similarity:	226/687 - (32%)	Gaps:	236/687 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 LKCGICLDVYTD----PRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSS 366
            |:|.||::.||:    |:.|.|.|:.|.|||       |.|               |.|.:.|
Frog    16 LECPICMEAYTEELLRPKLLQCGHTTCTQCL-------EKL---------------LASNING-- 56

  Fly   367 AELTATVSPARQRGSSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTC 431
                                                                       :||..|
Frog    57 -----------------------------------------------------------VRCPFC 62

  Fly   432 NYPTDLSLGGVRQLPQNYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLC 496
            :..|.::  .:..|..|..:::.|....|  |:.||. :.|..|...: ..:.|.:|.::||..|
Frog    63 SRVTRVT--SLANLADNLTVLKIINTSEL--GQTVIG-LMCKSCKRRL-PRFFCKNCIVSLCDAC 121

  Fly   497 KEAHE-------RQRSTASHRMRSILELRRAR-KQKQQQMGLGDSSKLVLRCGIHTNFELKAFCT 553
            |||..       .....|::..|..||.|.|: :|..|.:   ...|.:|. |:.:..:.| :.:
Frog   122 KEADHVLLNHIVLSLQDAANERRKTLEERLAKLRQCMQDL---QKRKSILE-GLTSQVKCK-YKS 181

  Fly   554 NCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEATDQTRPLCQYAEHSIERLNAIARGINDR 618
            ..:..:..:|.|........:..:.::....||..:..|:...|          ||.....:..|
Frog   182 ILQDYSKEECRVQEELARSRKMFTASLSEVEKLNSQMLDEQAYL----------LNITEVQLVSR 236

  Fly   619 CDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKVEVV--LKQQLDLEKRTQQAMDAVRFSQ 681
            ||.|..::::            ..|.|.:.|...|::.|:.  |..:|.|:            ..
Frog   237 CDYILLKIKQ------------SDTALLEDSLEEEAEPELAADLTSELTLQ------------DP 277

  Fly   682 ELCEIG-------ADV--------------EILSYVTILLRRLEY----------CQQFKPPVDP 715
            |..::|       ..|              |:.::.||..:.::.          |........|
Frog   278 EFLKVGHAGPIQVGQVVKKPYIVNMQEPLPEVSTFTTISYKEMDMQSEEISSVQSCPSAPLTKIP 342

  Fly   716 KISDSLHFLPKIRAPSTKDQR----DIPLYGIIT----MQVVEPSLCTLE---WEGFSQLRLHKK 769
            :.|.:|.....:|...:|...    ::|:...:|    :.|.:...|.::   .:||  ||..::
Frog   343 EASCNLQQCQFLRKMGSKGNMPGMFNLPVSLHVTALGEVLVADRGNCRIQVFNRKGF--LREIRR 405

  Fly   770 A-----DLLLHSRDADGVSL--------CHG---------------GLEINCMLKYKDSSSKFLP 806
            :     ..:|....||..:|        |||               .:|.:|:..::...||  |
Frog   406 SPSGIDTFVLSFLGADLPNLIPLSVTMNCHGLIGVTDNYDNSVKVYTMEGHCIACHRSQLSK--P 468

  Fly   807 VEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQARQVRPHTGIYHCCS------FC 865
            ..::....|.:.::   |.:|..:..:|: ||.:....::.....|||.   :..|.      |.
Frog   469 WGIAAMPSGQFVVT---DVEGGKLWCLTV-DRSLGVVKYSRLCNAVRPK---FVTCDQEGTVYFT 526

  Fly   866 SGKG----NRNVMCSCEGHMPGYSGCGHGHAGHPGRR 898
            .|.|    ||......||   |:|....|..|..||:
Frog   527 QGLGLNLENRQFEHHLEG---GFSIGSVGSDGQLGRQ 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	13/29 (45%)
		zf-B_box	537..576	CDD:279037	5/38 (13%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	24/142 (17%)
		Filamin	748..846	CDD:279024	24/128 (19%)
		IG_FLMN	751..849	CDD:214720	23/128 (18%)
trim32	NP_001096393.1	RING-HC_TRIM32_C-VII	17..63	CDD:319501	20/128 (16%)
		RING-HC finger (C3HC4-type)	18..62	CDD:319501	20/126 (16%)
		Bbox_SF	96..136	CDD:381767	10/40 (25%)
		NHL_TRIM32_like	358..640	CDD:271331	44/217 (20%)
		NHL repeat	370..410	CDD:271331	8/41 (20%)
		NHL repeat	427..466	CDD:271331	5/38 (13%)
		NHL repeat	468..507	CDD:271331	7/42 (17%)
		NHL repeat	509..560	CDD:271331	16/56 (29%)
		NHL repeat	573..605	CDD:271331
		NHL repeat	613..639	CDD:271331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010