DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and SLC5A6

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens

Alignment Length:	611	Identity:	200/611 - (32%)
Similarity:	315/611 - (51%)	Gaps:	69/611 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GMENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSE 72
            ||..  |..:||.||:.::|||.:.|:|..|                        ..:|...:.|
Human    20 GMST--FSIMDYVVFVLLLVLSLAIGLYHAC------------------------RGWGRHTVGE 58

  Fly    73 YLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSA 137
            .|:..|.:...|||:||:|::.|.|.|||..||||.:||||||:.....|..:..::::||||..
Human    59 LLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYR 123

  Fly   138 LQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCV 202
            |.:.|:|||||:||:..||...:..||...::::..::|.|::|||.|:|.:|.:..:.:.:||.
Human   124 LHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCT 188

  Fly   203 FYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVR 267
            .||.:||:|||:.||.:|.|||||..|||.|:.:....||..::..|::.||:.....:|.|:||
Human   189 VYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVR 253

  Fly   268 HTVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVC--CYVGLLIY 330
            ||.|::..||.....|...|||..||||:|  |..:..|.::.:.:.....||:|  |.:||:::
Human   254 HTFWTLAFGGVFMMLSLYGVNQAQVQRYLS--SRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMF 316

  Fly   331 EMYKDCDPLSAGLI-THDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILE 394
            ..|::. |:|.... ...||.:..||:..:..:.|:.|||||.:|..:||::|...||.:.|.:|
Human   317 AYYQEY-PMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTME 380

  Fly   395 DIVRGCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTL 459
            |::|..|. :.||..:.:|.:......|.:.|.:.::..|:..:|....|:..:..|...|||.|
Human   381 DLIRPWFP-EFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCL 444

  Fly   460 GMLVPWANTVGTAVGGIASALLAGWISFGTQFTIAAGEL-------NSQKLPVSVEGCVGNVTLR 517
            ||..|.||..|..||.:|..::|.||..|:..|.....:       :|..||.::  .|..||
Human   445 GMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNL--TVATVT-- 505

  Fly   518 ENIWVDEEQVFPL------------YRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLI 570
                    .:.||            |.|||.|.:.....||||||.:|||:|.....::|:|..|
Human   506 --------TLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATI 562

  Fly   571 SPVIHR---FLPKECFSGRNLHAQAH 593
            .||:.:   .||..|  .:.||.:::
Human   563 YPVLPKLLSLLPLSC--QKRLHCRSY 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	185/560 (33%)
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	187/565 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820