Protein Alignment SLC5A11 and SLC5A5

DIOPT Version :9

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_011526494.1
• Gene: SLC5A5 / 6528
• HGNCID: 11040
• Length: 654
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 183/607 - (30%)
• Similarity: 296/607 - (48%)
• Gaps: 70/607 - (11%)

  Fly     1 MEAVAKKGMENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF 65
            |||| :.| |...||:.||.||..|:::||..|::.|..:.
Human     1 MEAV-ETG-ERPTFGAWDYGVFALMLLVSTGIGLWVGLARG------------------------ 39

  Fly    66 GSEKMSEYLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYV 130
            |.....::..|.|.|...||.:||.||::|.|.:||..||.|.||.::.::.:..:|..:..:.:
Human    40 GQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALL 104

  Fly   131 YIPVFSALQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAV 195
            ::|||..|.:.|:||||||||...||...:..:|:..:|:...::|.||:.||||:|:::....:
Human   105 FMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLL 169

  Fly   196 VIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNT 260
            ...::|.|||.|||:||||.||.:||:||......|.....:...|...:...|....|:...:.
Human   170 STGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDF 234

  Fly   261 NPSPYVRHTVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVS--VCC 323
            ||.|..|:|.|:.::||...|.|...|||..||||::..:.|:|:.::.|..:|:...||  .||
Human   235 NPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACC 299

  Fly   324 YVGLLIYEMYKDCDPLSAGLITHDDQL-----------LPLFVVQSVGHIYGMSGLFIAGIFGAA 377
              |::::..|.|||||..|.|:..|||           :||.|:.....:.|:.|||:|..:...
Human   300 --GIVMFVFYTDCDPLLLGRISAPDQLSGRLTPSSPQYMPLLVLDIFEDLPGVPGLFLACAYSGT 362

  Fly   378 LSSLSVVLNSTSLVILEDIVRGCFK-MQPSERASTILVKSTVIVLGFVALSLVFVLEQL-SGILS 440
            ||:.|..:|:.:.|.:||:::...: :.|  |...|:.|...::.|...|::..:...| .|:|.
Human   363 LSTASTSINAMAAVTVEDLIKPRLRSLAP--RKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQ 425

  Fly   441 ICTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPV 505
            ...::..:.:|...|.|.|||.:|..||.|...|..|...|:.|::.|... ....|...:.||.
Human   426 GSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATL-YPPSEQTMRVLPS 489

  Fly   506 SVEGCVGNVTLRENIWVDEEQVFP----------------------LYRLSYHWINPIGVATVIV 548
            |...||. :::..:..:| ..:.|                      .|.:||.:...:|..|.::
Human   490 SAARCVA-LSVNASGLLD-PALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVL 552

  Fly   549 VGALVSLVTKPTNMKTLDPDLI 570
            .|||:|.:|.||...||.|.|:
Human   553 CGALISCLTGPTKRSTLAPGLL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	168/575 (29%)
SLC5A5	XP_011526494.1	SLC5sbd_NIS	15..565	CDD:271393	170/580 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850