Protein Alignment SLC5A11 and SLC5A4

DIOPT Version :9

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_016884409.1
• Gene: SLC5A4 / 6527
• HGNCID: 11039
• Length: 689
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 122/616 - (19%)
• Similarity: 230/616 - (37%)
• Gaps: 154/616 - (25%)

  Fly    51 PTLPTTTPKRRKHDFGSEKMSE-----------YLLGSRNLKVFPVAMSLIASYIS-----GVTI 99
            |.|.:.||.:|.....|...|.           :.|..|::..:|:..||.||.|.     |:..
Human    55 PVLLSETPTKRHGPLASHNHSAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAG 119

  Fly   100 LGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSYEYLEMRFH----SVVRSIAS 160
            .|..|.:... |..|..::.:::.|    ::::|::....|.:..|||:.||.    .|..||.|
Human   120 TGAASGVATV-TFEWTSSVMLLILG----WIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILS 179

  Fly   161 FMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMF 225
            ....:  :|.:...::..||.:....|::|::...:::.:...||..||:.:|::||..|.::|.
Human   180 LFICV--VLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIML 242

  Fly   226 LSVLAV--------------------AILATVYANGLNV-------------LFDDAAKGGRLIF 257
            :....:                    |..:.|..:.|.:             :|.||..|
Human   243 IGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTG----- 302

  Fly   258 NNTNPSPYVRHTVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARAS---------MAIFTI 313
              ..|.|.:   ::.:.|....||    ..||.:|||.:....:...:|:         :.:|.:
Human   303 --DIPWPGI---IFGMPITALWYW----CTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLM 358

  Fly   314 GVAAFVSVCCYVGLLIYEMYKDCDPLSAGLITH-------DDQLLPLFVVQSVGHIYGMSGLFIA 371
            .:...:|...|..::...:..:|       :.|       .:...|..|::.:..  |:.||.::
Human   359 VMPGMISRILYTDMVACVVPSEC-------VKHCGVDVGCTNYAYPTMVLELMPQ--GLRGLMLS 414

  Fly   372 GIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERASTILVKSTVIVLGFVALSLVFV----L 432
            .:..:.:|||:.:.||.|.:...|:..   ||:.......:|:...:.||....:|:|:|    :
Human   415 VMLASLMSSLTSIFNSASTLFTIDLYT---KMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 476

  Fly   433 EQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALLAGWISFGTQFTIAAGE 497
            .|...::....|:::........:|.|.:.....|..| |..|:...|..|.|...|:|....|.
Human   477 SQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQG-AFWGLMVGLAMGLIRMITEFAYGTGS 540

  Fly   498 -LNSQKLPVSVEGCVGNVTLRENIWVDEEQVFPLYRLSYHWINPIGVATVIVVGAL-----VSLV 556
             |.....|..:.|                 |..||           .:.|:..|::     :||:
Human   541 CLAPSNCPKIICG-----------------VHYLY-----------FSIVLFFGSMLVTLGISLL 577

  Fly   557 TKPTNMKTLDPDLISPVIHRFLPKECFSGRN 587
            |||.           |.:|  |.:.|:..||
Human   578 TKPI-----------PDVH--LYRLCWVLRN 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	112/583 (19%)
SLC5A4	XP_016884409.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750