Protein Alignment SLC5A11 and SLC5A3

DIOPT Version :9

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_008864.4
• Gene: SLC5A3 / 6526
• HGNCID: 11038
• Length: 718
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 121/593 - (20%)
• Similarity: 222/593 - (37%)
• Gaps: 114/593 - (19%)

  Fly    70 MSEYLLGSRNLKVFPVAMSLIASYISGVTILGT--TSEIYNYGTQYWFIAIAIMLQGIAVSYVYI 132
            :|.|.|..|::....:..||..|.|.....:|.  :.....:....|.....::||  .:.:|:|
Human    36 VSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQ--LLGWVFI 98

  Fly   133 PVFSALQVGSSYEYLEMRF--HSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAV 195
            |::....|.:..|||..||  |.:....|:...||.....|...:|..|:.:.:..|.||:|..:
Human    99 PIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVI 163

  Fly   196 VIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLI---- 256
            :::.:....|..||:.||::||..|.|:|.:..|.:.|::.:...|    |::..:...|.
Human   164 LLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGG----FEEVKRRYMLASPDV 224

  Fly   257 --------FNNTNP--------------SPYVRHTVWSVLIGGFS-----YWTSFNAVNQTMVQR 294
                    .:|||.              :|......|...|.|.:     ||    ..:|.:|||
Human   225 TSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYW----CADQVIVQR 285

  Fly   295 YMSLPSLKKARAS---------MAIFTIGVAAFVSVCCYVG----------LLIYEMYKDCDPLS 340
            .::..::..|:.|         :.:|.|.|...:|...:..          :|:......|..::
Human   286 VLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIA 350

  Fly   341 AGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQP 405
                      .|..|::.|.  .|:.||.:|.:..|.:|.|..:.||.|.:...|:.:   .::.
Human   351 ----------YPRLVMKLVP--VGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYK---LIRK 400

  Fly   406 SERASTILVKSTVIVLGFVALSLVFV---LEQLSG-----ILSICTSMTAIAAGTTFGLFTLGML 462
            |..:..:::...:.|...|.:|:.:|   :|...|     |..:...:|...|    .||.|.:.
Human   401 SASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVA----ALFLLAIF 461

  Fly   463 VPWANTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQV 527
            ....|..|...||:|..:| |.:.....|...|.|.:.   |.:..|.:.::.
Human   462 WKRCNEQGAFYGGMAGFVL-GAVRLILAFAYRAPECDQ---PDNRPGFIKDIH------------ 510

  Fly   528 FPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPKECFSGRNLHAQA 592
            :........|:.  |:.|||     |||:|.|...:.:.........:..:.:.|......:...
Human   511 YMYVATGLFWVT--GLITVI-----VSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYKMQ 568

  Fly   593 HKNLLNVS 600
            .|::|..|
Human   569 EKSILRCS 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	114/547 (21%)
SLC5A3	NP_008864.4	SLC5sbd_SMIT	9..718	CDD:271382	121/593 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750