Protein Alignment SLC5A11 and SLC5A1

DIOPT Version :10

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 114/562 - (20%)
• Similarity: 219/562 - (38%)
• Gaps: 101/562 - (17%)

  Fly    73 YLLGSRNLKVFPVAMSLIASYIS-----GVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYI 132
            :.|..|::..:|:..||.||.|.     |:...|..|.|...|.::..:.:.::|     .::::
Human    58 FFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVL-----GWLFV 117

  Fly   133 PVFSALQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFI-----VYVPAIALNQVSGINLHV 192
            |::....|.:..|||..||..  :.|..::.:|..:|:: |.     ::..||.:|...|:||::
Human   118 PIYIKAGVVTMPEYLRKRFGG--QRIQVYLSLLSLLLYI-FTKISADIFSGAIFINLALGLNLYL 179

  Fly   193 IAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIF 257
            ...:::.:...||..||:.||::||..|.::|.:..|.:...|.....|.:...:...|....|.
Human   180 AIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIV 244

  Fly   258 NNTNPS------------------PYVRHTVWSVLIGGFS-----YWTSFNAVNQTMVQRYMSLP 299
            ::.|.:                  |......|...|.|.|     ||    ..:|.:|||.:|..
Human   245 SDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYW----CTDQVIVQRCLSAK 305

  Fly   300 SLKKARAS---------MAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPLSAGLITHDDQLLPLFV 355
            ::...:..         |.:|.:.:...:|...|...:...:..:|:......:...:...|..|
Human   306 NMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLV 370

  Fly   356 VQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERASTILVKSTVIV 420
            |:.:.:  |:.||.::.:..:.:|||:.:.||.|.:...||..   |::.......:::...:.:
Human   371 VELMPN--GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYA---KVRKRASEKELMIAGRLFI 430

  Fly   421 LGFVALSLVFV----LEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALL 481
            |..:.:|:.:|    ..|...:.....|:|:........:|.|.:.....|..| |..|:...||
Human   431 LVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPG-AFWGLILGLL 494

  Fly   482 AGWISFGTQFTIAAGE-LNSQKLPVSVEGCVGNVTLRENIWVDEEQVFPLYRLSYHWINPIGVAT 545
            .|.....|:|....|. :.....|..:.|                       :.|.:...|..|.
Human   495 IGISRMITEFAYGTGSCMEPSNCPTIICG-----------------------VHYLYFAIILFAI 536

  Fly   546 VIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPKECFSGRN 587
            ..:...::||:|||.           |.:|  |.:.|:|.||
Human   537 SFITIVVISLLTKPI-----------PDVH--LYRLCWSLRN 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	103/529 (19%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	114/562 (20%)