Protein Alignment SLC5A11 and SLC5A7

DIOPT Version :9

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_001291934.1
• Gene: SLC5A7 / 60482
• HGNCID: 14025
• Length: 580
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 113/591 - (19%)
• Similarity: 226/591 - (38%)
• Gaps: 122/591 - (20%)

  Fly    60 RRKHDFGSEKMSE-YLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQ 123
            |.|:...:|:.|| .::|.|::.:.....::.|:::.|..|.||...:|              :.
Human    28 RTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVY--------------VP 78

  Fly   124 GIAVSYVYIPVFSALQ--VGSSYEYLEMRFHSVVRSIASFMFI----LDEILFLPFIV----YVP 178
            |..:::...|:..:|.  :|..:....||....|..:..|..|    :..:||:|.::    :..
Human    79 GYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAA 143

  Fly   179 AI------ALNQVSGINLHVIAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSV-------LA 230
            ||      .::.:..:::|:..::..::...||.|||:.:|.:||..|:..:|:.:       |:
Human   144 AIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALS 208

  Fly   231 VAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWS---VLIGGFSYWTSFNAVNQTMV 292
            ...:|.:....::..:.....|       |..|..|...:.|   :::||..:        |...
Human   209 HPAVADIGFTAVHAKYQKPWLG-------TVDSSEVYSWLDSFLLLMLGGIPW--------QAYF 258

  Fly   293 QRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPLSAGL----ITHD-DQLLP 352
            ||.:|..|...|:....:...|..........:|.:  ....|.:..:.||    .|.: |.:||
Human   259 QRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAI--GASTDWNQTAYGLPDPKTTEEADMILP 321

  Fly   353 LFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERASTILVKST 417
            : |:|.:..:| :|...:..:..|.:||....:.|.|.:...:|.:..|:...|::....:::.|
Human   322 I-VLQYLCPVY-ISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRIT 384

  Fly   418 VIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALLA 482
            |.|.|..|.::..:.:.:.|:..:.:.:..|   ..|......:.|...||.|.         :|
Human   385 VFVFGASATAMALLTKTVYGLWYLSSDLVYI---VIFPQLLCVLFVKGTNTYGA---------VA 437

  Fly   483 GWISFGTQFTIAAGE--------------------LNSQKLPVSVEGCVGNVTLRENIWVDEEQV 527
            |::| |....|..||                    :.:||.|......|  .:...||.:.
Human   438 GYVS-GLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMV--TSFLTNICIS---- 495

  Fly   528 FPLYRLSYHWINPIGVATVIVVGALV----------SLVTKPTNMKTLDPDLISP-----VIHRF 577
               |...|.:.:......:.|..|:|          :::.|..|:|..:..|:.|     :...|
Human   496 ---YLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTF 557

  Fly   578 LPKECF 583
            ..||.|
Human   558 TNKEAF 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	104/557 (19%)
SLC5A7	NP_001291934.1	SLC5sbd_CHT	8..495	CDD:271368	99/514 (19%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250|UniProtKB:Q9JMD7	502..580		12/62 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740