DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and slc5a3b

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_005167848.1	Gene:	slc5a3b / 568338	ZFINID:	ZDB-GENE-070912-43	Length:	709	Species:	Danio rerio

Alignment Length:	587	Identity:	120/587 - (20%)
Similarity:	207/587 - (35%)	Gaps:	182/587 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MSEYLLGSRNLKVFPVAMSLIASYISGVTILGT--TSEIYNYGTQYWFIAIAIMLQGIAVSYVYI 132
            :|.|.|..|.:....:..||..|.|.....:|.  :.....:....|.....::||  .:.:|:|
Zfish    39 VSGYFLAGRTMNWAVIGASLFVSNIGSEHFIGLAGSGAASGFAVAAWEFNALLLLQ--LLGWVFI 101

  Fly   133 PVFSALQVGSSYEYLEMRFHSVVRSI--ASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAV 195
            ||:....|.:..|||..|:......|  |....:|.....|...:|..|:.:.:..|.||::..:
Zfish   102 PVYIHSGVYTMPEYLSKRYGGKRLKIYFAGLSLLLYIFTKLSVDLYAGALFIQESLGWNLYLSII 166

  Fly   196 VIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVL---FDDAAKGGRLIF 257
            :::.:....|..||:.||::||..|.::|....|.:.|::.:...||..:   :.:|......|.
Zfish   167 LLISMTALLTVTGGLVAVIYTDTLQAVLMIGGALTLTIISLIKVGGLEGVREKYMEAVPNVTAIL 231

  Fly   258 NNTNPS---------------------PYVRHTVW-SVLIG----GFSYWTSFNAVNQTMVQRYM 296
            .::|.|                     |......| ..|:|    ...||    ..:|.:|||.:
Zfish   232 ASSNFSFEYTNSCRIYPKPDSLKLLRGPLDEDIPWPGFLLGQTPSSIWYW----CADQVIVQRVL 292

  Fly   297 SLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPLSAGLITHDDQLLPLFVVQSVGH 361
            :..::..|:.|                              .|.||::    ::||:|::...|.
Zfish   293 AAKNIAHAKGS------------------------------TLMAGVL----KILPMFIIVIPGM 323

  Fly   362 I-----------------------------------------YGMSGLFIAGIFGAALSSLSVVL 385
            |                                         .|:.||.:|.:..|.:|.|..:.
Zfish   324 ISRILFPDELACIGPEHCMAVCGSQAGCSNIAYPRLVMSVMPVGLRGLMMAVMIAALMSDLDSIF 388

  Fly   386 NSTSLVILEDIVRGCFKMQPSERAST--ILVKSTVIVLGFVALSLVFV--------------LEQ 434
            ||.|.:...||    :||..: |||:  ::|...:.|:..||:|:.:|              :::
Zfish   389 NSASTIFTLDI----YKMLRA-RASSRELVVIGRIFVIFMVAISIAWVPVIIEMQGGQMYLYIQE 448

  Fly   435 LSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALLAGWISFGTQFTIAAGELN 499
            ::|.|:     ..|||     ||.||:.....|.:|...||:...:|      ||...:......
Zfish   449 VAGYLT-----PPIAA-----LFLLGVFWKRCNEIGAFCGGMTGFVL------GTTRLLLGFIYR 497

  Fly   500 SQKLPVSVEGCVGNVTLRENIWVDEEQVFPLYRLSY-------HWINPIGVATVIVVGALVSLVT 557
            ..|....                ||...| :.|:.|       .||:.:       |..:|||.|
Zfish   498 EPKCDQP----------------DERPAF-ITRIHYMYIAAGLFWISGL-------VAVVVSLCT 538

  Fly   558 KP 559
            .|
Zfish   539 TP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	117/582 (20%)
slc5a3b	XP_005167848.1	SLC5-6-like_sbd	12..709	CDD:294310	120/587 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850