DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and slc5a11

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001007301.1	Gene:	slc5a11 / 492334	ZFINID:	ZDB-GENE-041114-9	Length:	668	Species:	Danio rerio

Alignment Length:	472	Identity:	113/472 - (23%)
Similarity:	193/472 - (40%)	Gaps:	108/472 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAI----MLQGIAVSYVYIP 133
            |.|..:|:..:||..||.||.:.....:|....    |......|:|.    ||..:.:.::::|
Zfish    58 YFLAGKNMTWWPVGASLFASNVGSGHFIGLAGS----GAAAGIGAVAYEWNGMLMVLVMGWLFLP 118

  Fly   134 VFSALQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFI------VYVPAIALNQVSGINLHV 192
            ::.|.:|.:..|||:.||..  :.|..|:.:|  .||:...      :|..|:.:.|....|:::
Zfish   119 IYIASRVTTMPEYLKKRFGG--KRIQLFLCVL--YLFIYIFTKISVDMYAGAVFIQQALQWNIYL 179

  Fly   193 IAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFD---DAAKGGR 254
            ..|:::.:...||..||:.||::|||.|.::|.:..|.:...:.....|...:.|   .|....|
Zfish   180 AVVLLLGITALYTIAGGLAAVIYTDAVQTIIMVIGALILMGFSFAEVGGFEAVLDKYPQAIPSIR 244

  Fly   255 LIFNNTNPSP------YVRHTV-----WSVLIGGFS-----YWTSFNAVNQTMVQRYMSLPSLKK 303
             :.|.|...|      ..||.|     |..:|.|.|     ||.|    :|.:|||.::..::..
Zfish   245 -VPNTTCGIPRDDAFHIFRHPVTSDLPWPGVILGMSIPSMWYWCS----DQVIVQRSLAAKNILH 304

  Fly   304 ARASMAIFTIGVAAFVSVCCYV-----GLLIYEMYKD---------CDPLSAGLITHDD------ 348
            |:....:     ||::.|..:.     |::...:|.|         |..:....:...|
Zfish   305 AKGGSLL-----AAYIKVLPFFMMVIPGMISRILYPDEVGCGDPEVCKEVCGNSVGCSDIAYAKL 364

  Fly   349 --QLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERAST 411
              :|||.          |:.||.:|.:..|.:|||:.:.||:|.:...|:.|   .::.:.....
Zfish   365 VMELLPA----------GLRGLMMAVMLAALMSSLTSIFNSSSTIFTMDLWR---NIRHTASEWE 416

  Fly   412 ILVKSTVIVLGFVALSLVFV-LEQLS--GILSICTS---------MTAIAAGTTF-------GLF 457
            :::...|.||..|.:|:::: |.|.|  |.|.|...         :|.|.....|       |.|
Zfish   417 LMIVGRVFVLVLVVVSVLWIPLVQASQGGQLFIYIQSISMYLQPPITVIFVAGCFWKRTNEKGAF 481

  Fly   458 TLGMLVPWANTVGTAVG 474
                   |...||.|||
Zfish   482 -------WGLMVGMAVG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	113/472 (24%)
slc5a11	NP_001007301.1	SLC5sbd_SGLT6	28..668	CDD:271381	113/472 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750