DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC5A11 and Smvt

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	186/580 - (32%)
Similarity:	307/580 - (52%)	Gaps:	48/580 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGSR 78
            |.:.||.||..::.:|.:.|:|||...|                        |.:...|||:|.:
  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAK------------------------GEDTTEEYLMGGK 64

  Fly    79 NLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSS 143
            .:|..|:|:||:||.:|.::|:...:|:|.||..:.|..:.::|....::|:.||||....:.:.
  Fly    65 RMKTIPIAISLVASQLSAISIMTIPAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNC 129

  Fly   144 YEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVG 208
            ||||||||...||.:.:|:|||.....||..:::|::|..||:|.|:|:|..|:..:|||||..|
  Fly   130 YEYLEMRFCRKVRVLQTFIFILTMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFG 194

  Fly   209 GIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSV 273
            ||||||.||..|..:|..||:.|.:|......|...:...|.:||||.. |.|.....|.|:|::
  Fly   195 GIKAVVWTDVIQAAIMVASVVLVGVLGAHRVGGFFEVLRIAGEGGRLDI-NYNFDLTTRSTIWNI 258

  Fly   274 LIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDP 338
            .......||.:..:||:.|||.:|||||..||.|:.:|..|....:...|:.|::||..:.||||
  Fly   259 FTSATMMWTGYVGLNQSCVQRIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDP 323

  Fly   339 LSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKM 403
            :.:|.::..|:::|.||..:||:::||.|:||:.:|.||||:||..:||...|:..|.::.  .:
  Fly   324 IQSGHVSKVDKMVPYFVQDTVGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKP--HI 386

  Fly   404 QPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANT 468
            :.:|..:.:::|..|...|...:....|:|..:.||.:..|:..::.|:|.|:|.||||||.::.
  Fly   387 RHTEHRANVIMKLFVFFTGIYCILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHG 451

  Fly   469 VGTAVGGIAS-ALLAGWISFGTQFTIAAGELNSQKLPVSVEGC-------VGNVTLRENIWVDE- 524
            ....||.:|| |.:|      |...::.|..:...||.|...|       :.:::....:::..
  Fly   452 RAALVGVLASIACMA------TIVILSWGRNHYDTLPTSTSACPASLNGTIKDISTASPLFLGST 510

  Fly   525 ------EQVFPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFL 578
                  |:.|.:..||::|....|.....::|..:|.:.|.......:|.|:|||:..|:
  Fly   511 TEAPVGEKEFSILDLSFNWYTVTGFVITWLIGIPLSYILKSGPDYKPNPKLLSPVVQPFV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	178/553 (32%)
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	178/553 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448227
Domainoid	1	1.000	97	1.000	Domainoid score	I370
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900