DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and salt

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_651889.3	Gene:	salt / 43742	FlyBaseID:	FBgn0039872	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	195/599 - (32%)
Similarity:	306/599 - (51%)	Gaps:	55/599 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEY 73
            :|:..|...||.||..|:..|...|:|||...|:|           .||             .||
  Fly    20 LEDLHFSLTDYIVFSLMLSASAGIGVYFGFFSKAK-----------NTT-------------EEY 60

  Fly    74 LLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSAL 138
            |.|.:.:...|||:||::|.:|||.::...:|.|::|....|:..|::|....:.|:.:|||...
  Fly    61 LQGGKRMPTLPVAISLVSSQLSGVAMMSVPAETYSFGFNMIFVVWAMVLSVPVLIYIIVPVFYDN 125

  Fly   139 QVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVF 203
            .|.:.|||||:||....|.:.:..|||::.|.||..::||::|.:||:|.|:|:|..|:..:|||
  Fly   126 NVSNCYEYLELRFSKRTRQLVTITFILNQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVF 190

  Fly   204 YTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRH 268
            ||.:|||||||.||..|..||.:||:.||||.|....|:..:.::||:|||..| :....|.:|.
  Fly   191 YTMLGGIKAVVWTDVVQGSVMLISVVLVAILGTSNTGGITNVLENAAEGGRFDF-SFGIDPRLRL 254

  Fly   269 TVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMY 333
            |..|.:..|...||....::|:.|||.:||||...|:..:.:..:|....:|..|:.|::::..|
  Fly   255 TFISGMASGLLMWTGKLGLDQSCVQRIVSLPSYGHAKRCLLMAGVGFLLIMSFTCFTGIIMFAYY 319

  Fly   334 KDCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVR 398
            ..|||:.|||::..|:|:|.|:...:||:.||.|:||:.:|.|:|||||..|||.:.|:..|.::
  Fly   320 YGCDPIQAGLVSKPDKLMPFFIQDIMGHMMGMPGVFISCVFSASLSSLSASLNSFAGVVYFDYIK 384

  Fly   399 GCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLV 463
            .  ::..||..:...:|..::|:|...:...|:::..:.|:....::|.|..|...|:|.|||.|
  Fly   385 P--RINHSEAKANATMKLVIVVMGAYCIVGGFIVQNFNSIIQTMWTITGINMGAVVGVFCLGMFV 447

  Fly   464 PWANTVGTAVGGIA-SALLAGWISFGTQFTIAAGELNSQKLPVSVEGC-------VGNVTLRENI 520
            |..| ...||.||| |.|:..||....|....||.:....||..::.|       :.|....:|:
  Fly   448 PRCN-AKVAVSGIAFSCLVMLWIIINGQMNFKAGLIKYDPLPNGLDQCEAKGFEVILNAIRNKNV 511

  Fly   521 W-------------------VDEEQVFPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLD 566
            .                   .|..:.|.:|..|::|...:|...|......:|.|......:..:
  Fly   512 TNVGTTAIPSLEAPKELTTAFDSNRDFSIYDTSFYWYKVLGALLVFAWAIPMSYVWPLDKEEKQN 576

  Fly   567 PDLISPVIHRFLPK 580
            |.|.||.:...|.|
  Fly   577 PKLYSPFVRSMLNK 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	186/565 (33%)
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	186/565 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448223
Domainoid	1	1.000	97	1.000	Domainoid score	I370
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900