DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and CG42235

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	220/592 - (37%)
Similarity:	336/592 - (56%)	Gaps:	22/592 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FGSVDYAVFLGMIVLSTSTGIYFGCI--KKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLG 76
            ||.|||.||:.|:.:....|.|||.|  |:.|.||...:........:||    |||.: :||:|
  Fly   102 FGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERR----GSEAL-DYLVG 161

  Fly    77 SRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVG 141
            .|.:||||||:||:||::||:::|||::|||.|||||.||.:.:.:.|....|:::|||..||:.
  Fly   162 GRQMKVFPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLT 226

  Fly   142 SSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTF 206
            |:|||.|.||...||...|.:|::..||:.|..:||||:.|||||||::..|..|...:|:.||.
  Fly   227 STYEYFERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTS 291

  Fly   207 VGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVW 271
            |||||.||.||..|..||..|:|.|.|..|:...||:|:.|...:..||:..:....|..|..|:
  Fly   292 VGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVF 356

  Fly   272 SVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDC 336
            ::.:||..:....|.:||.:||||::||:.|..:.::.:..||....:.:|.|:|||.:..:..|
  Fly   357 ALFVGGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEFYHC 421

  Fly   337 DPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCF 401
            ||::.||....||::||:||::||||.|:.|||:||:|.|||||||..|||.|.|||.|.|....
  Fly   422 DPITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFR 486

  Fly   402 KMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWA 466
            |...:||.:..|::..||..|.::::.|.::::|..::.:.:::.||..|...|.|::|||:|:.
  Fly   487 KKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFV 551

  Fly   467 NTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQVFP-- 529
            .|.....|...::....:|....|..|..|.|.....|||::.|.....|..| |.......|
  Fly   552 KTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPAN-WNATTTATPTE 615

  Fly   530 -----LYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRF-------LPKEC 582
                 ::.:|:.|...:|....::...|.:|.....:.:.:|.:|||||:.:|       :..|.
  Fly   616 STSHGIHEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRKFWYGKYESVASEE 680

  Fly   583 FSGRNLH 589
            .:..|||
  Fly   681 KNNFNLH 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	206/547 (38%)
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	206/546 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448254
Domainoid	1	1.000	74	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32058at33392
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900