DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and CG7720

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	169/615 - (27%)
Similarity:	286/615 - (46%)	Gaps:	72/615 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEK---MSEYLLGSRN 79
            ||.:|:..|.|:....::                          |..||.:|   .::|:..:..
  Fly    11 DYLMFVLFIALTVLGPLW--------------------------KRIFGKKKERSKADYVFATGG 49

  Fly    80 LKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSY 144
            :.:..|.:|:....:...::||..||:|..|:..|.|...:|.....|.::::||:..|.:.|.|
  Fly    50 VSIVAVMISIARGTLGVRSVLGYPSELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVY 114

  Fly   145 EYLEMRFHS-VVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVG 208
            :|:::||.| .||.:||..:|:.:|..|...||.|::||:.|.||........:.|:|:|:|.:|
  Fly   115 QYIDLRFKSRTVRCLASATYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMG 179

  Fly   209 GIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSV 273
            |:||.::.|..|.:.:.:..:||.|..|:...|:..::......|||.|.|......||....|.
  Fly   180 GLKAAINADVIQTVTILVVTVAVCIQGTISTGGVKKVYQLNRDNGRLNFWNFTGDMTVRVDTTSA 244

  Fly   274 LIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDP 338
            .:|......|.....|..:|||:||.|||:.|..|......|..|.|:....|::||..|.:|||
  Fly   245 WLGQLFMSLSQIGCQQNFMQRYVSLKSLKQVRRVMLTNVPLVFFFFSISWISGMVIYSTYINCDP 309

  Fly   339 LSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKM 403
            .:.|.|...|::||.||...:|.:.|..|:|:|.:|..||..:...|||.:.||.||.:....|.
  Fly   310 YAEGYIKKPDEILPFFVEDQLGFLPGFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKF 374

  Fly   404 QP-SERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWAN 467
            :. |::....::||..:|.|.:.:.:.|.:..|:|::.....:.:..:|...|.|.|.|:||.||
  Fly   375 KGLSDKQQLRILKSITVVCGLIIMGVAFGVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIAN 439

  Fly   468 TVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENI-----------W 521
            ..||:.|.:.:.....|| .|...|:..   ::..||.|.:||. |.|..::|           |
  Fly   440 WKGTSAGMVTACAFVLWI-IGGGMTVTK---DNPLLPTSTDGCT-NDTFAQSIGKPIVEQGQMPW 499

  Fly   522 V---------------DEEQVFP-------LYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKT 564
            :               .:..:.|       .|.:|:.:.:.||.|..:::|.::||:|:..: ..
  Fly   500 LLSHTPIDGFNQSFVPTQPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLTQHPD-DA 563

  Fly   565 LDPDLISPVIHRFLPKECFSGRNLHAQAHK 594
            .|..|:.|:|.|..  |.||||..:...|:
  Fly   564 YDGKLLHPLIFRLC--ERFSGRKPYYVKHE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	156/575 (27%)
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	156/575 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970