DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and slc5a1

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_956975.1	Gene:	slc5a1 / 393654	ZFINID:	ZDB-GENE-040426-1524	Length:	658	Species:	Danio rerio

Alignment Length:	576	Identity:	118/576 - (20%)
Similarity:	229/576 - (39%)	Gaps:	132/576 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YLLGSRNLKVFPVAMSLIASYIS-----GVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYI 132
            :.|..|::..:|:..||.||.|.     |:...|..:.|...|.::..:.:.|:|     .::::
Zfish    58 FFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNALVVVIIL-----GWLFV 117

  Fly   133 PVFSALQVGSSYEYLEMRFHSVVRSIASFMFILDEILF----LPFIVYVPAIALNQVSGINLHVI 193
            |::....|.:..|||:.||..  :.|..::.:|...|:    :...::..||.:||..|:|:::.
Zfish   118 PIYIKAGVVTMPEYLKKRFGG--QRIRIYLSVLSLCLYVFTKISADMFAGAIFINQALGLNIYLA 180

  Fly   194 AVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFL----------------------------SVLA 230
            .|:::::...||..||:.||::||..|.::|.:                            ||:.
Zfish   181 VVILLLITALYTVTGGLAAVIYTDTLQTIIMVVGSFILMGFAFNKVGGYENFRDSYMTAIPSVIG 245

  Fly   231 VAILATVY---ANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSVLIGGFS-----YWTSFNAV 287
            ..|..:.|   |:..::..|.        .|...|        |..|:.|.:     ||    ..
Zfish   246 TNISESCYTPRADSFHIFRDP--------INGDLP--------WPGLLFGLTIQAGWYW----CT 290

  Fly   288 NQTMVQRYMSLPSLKKARASMAI--FTIGVAAFVSVCCYVGLLIYEMYKD---------CDPLSA 341
            :|.:|||.:|..:|...:|...:  :...:..|:.|  :.|::...:|.|         |..:..
Zfish   291 DQVIVQRCLSAKNLSHVKAGCILCGYLKLLPMFLMV--FPGMISRVLYPDEIACVDPDECKAVCG 353

  Fly   342 GLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPS 406
            ..:...:...|..||..:.:  |:.||.::.:..:.:|||:.:.||.|.:...||..   |::|.
Zfish   354 AEVGCTNIAYPKLVVDLMPN--GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYT---KIRPK 413

  Fly   407 ERASTILVKSTVIVLGFVALSLVFV----LEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWAN 467
            .:...:::...:.:|..:.:|:.::    ..|...:.....|:|:..|.....:|.|.:.....|
Zfish   414 AKEKELMIAGRLFMLLLIGISIAWIPIVQTAQSGQLFDYIQSITSYLAPPIAAVFALAIFCKRVN 478

  Fly   468 TVGTAVGGIASALLAGWISFGTQFTIAAGE-LNSQKLPVSVEGCVGNVTLRENIWVDEEQVFPLY 531
            ..| |..|:...||.|.....|:|....|. :|....|..:.|                     .
Zfish   479 EPG-AFYGLCVGLLVGLARMITEFAYGTGSCVNPSNCPTIICG---------------------V 521

  Fly   532 RLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPKECFSGRN 587
            ...|..:...|::.::::.  :||:|||...|.|         :|.    |:|.||
Zfish   522 HYLYFALILFGLSCILILS--ISLMTKPIEDKHL---------YRL----CWSLRN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	107/543 (20%)
slc5a1	NP_956975.1	SLC5sbd_SGLT1	27..658	CDD:271379	118/576 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750