DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and CG5687

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	196/579 - (33%)
Similarity:	311/579 - (53%)	Gaps:	50/579 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGSR 78
            |...||.:.|||:|:|...||::|..:|                        |....:|:||||
  Fly    96 FSGYDYVILLGMLVISLGIGIFYGFFQK------------------------GGSSSNEFLLGS- 135

  Fly    79 NLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSS 143
            .:.:|||.:||..|:|:.:.:||..||:|..|||:..|.|.:::.......::.|::..:::.|.
  Fly   136 EMSIFPVTLSLTTSFITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSC 200

  Fly   144 YEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVG 208
            ||||.:||...:|.:.:.::::....:....|..|||||::.:|::..:..|:|.||||||:..|
  Fly   201 YEYLGIRFGKEIRILGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQG 265

  Fly   209 GIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSV 273
            |:||||..|::|..|:.:|::.:..|...|:.....:|..|:...||.|.|.:|.|..|||||||
  Fly   266 GMKAVVIADSFQAAVLAVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSV 330

  Fly   274 LIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDP 338
            :||||.||||....||..||:.|||.||:.|:.::....||:.....:..|.||:::..|.||||
  Fly   331 VIGGFFYWTSLFCTNQASVQKCMSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDP 395

  Fly   339 LSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILED-IVRGC-F 401
            |:||.|:..|||||.:|:.:..||..::|:|:||||.|:|.:::..|||.|.|..|| :|.|. .
  Fly   396 LTAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNI 460

  Fly   402 KMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWA 466
            |:.|.:.|:  ..|...:..|..:..|||::|.|.|:|....::..:..|.|.|||.||:....|
  Fly   461 KISPEKGAT--YAKWMSLGFGIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQA 523

  Fly   467 NTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGC---------VGNVTLRENIWV 522
            ||.|...||:.|..|..::....|..    .:....||.|::.|         :|:: |.|.:.|
  Fly   524 NTKGAFYGGLLSLALVIFVGVVAQIV----SVEQPALPTSIDKCDCHVNMTNIIGSL-LTEPLEV 583

  Fly   523 DEEQVF---PLYRLSYHWINPIGVATVIVVGALVSL----VTKPTNMKTLDPDLISPVI 574
            .||..|   |::||||.|.:.||....:.:|..:||    :.:...:|....|:.:|.:
  Fly   584 IEEGGFTSWPIFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNVLKITGKDIDNPAV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	192/556 (35%)
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	191/552 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D32058at33392
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	9	8.970