DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and CG32669

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	204/561 - (36%)
Similarity:	309/561 - (55%)	Gaps:	61/561 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GSVDYAVFLGMIVLSTSTGIYFGCI--KKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGS 77
            |:.||.:...::::|.:.|||:..:  |:|            |||              ||||..
  Fly     5 GAWDYTILAVVLIISVAIGIYYRFVGGKQS------------TTT--------------EYLLAD 43

  Fly    78 RNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGS 142
            |::.|.|||.||:||::|.|||||.:.|.|.|||.:..|.::.:|.....:|:.||||..|:..|
  Fly    44 RSMNVAPVAFSLMASFMSAVTILGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTAS 108

  Fly   143 SYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIV-VVCVFYTF 206
            .|||||:||....|..||..|.|..:|::..:||.||:||..|:|:: .|.::||| |||.||..
  Fly   109 VYEYLELRFGYATRLAASLSFSLQMVLYMGIVVYAPALALEAVTGLS-QVFSIVIVGVVCTFYAT 172

  Fly   207 VGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVW 271
            :||:|||:.||.:|.|:||.:|.:|.|.|.|.|..|.|::..|.:.||:...|.:..|..|||.:
  Fly   173 LGGMKAVLITDIYQSLLMFAAVFSVIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWF 237

  Fly   272 SVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSV-CCYVGLLIYEMYKD 335
            :.::||.:.:.:...||||.|||.|::.||..|||:: .:.:.:...:|: .|:.||.||..|:|
  Fly   238 TQILGGCATYLAIYGVNQTQVQRLMAVKSLSAARAAL-WWCLPILCLLSLSTCFSGLCIYWYYRD 301

  Fly   336 CDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILED----I 396
            ||||..|.:...||::|||||.::|...|::|||::|||.|:||::|.:::|.:.|.|||    :
  Fly   302 CDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPL 366

  Fly   397 VRGCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGM 461
            |..|.|...::|.:....|...:..|.:.:.:.|:...:.|:|....|:..|..|...|||||||
  Fly   367 VSCCAKRTLTDRQTLWYSKLLSLFFGALCIGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGM 431

  Fly   462 LVPWANTVGTAVGGIASAL-LAGWISFGTQFTIAAGELNSQKLP-----VSVEGCVGNVTLRENI 520
            .|..||..| |:||:..:| ...||.||           ..|.|     :|..||..:.:...:|
  Fly   432 YVTKANEKG-AIGGLLISLAFCFWIGFG-----------QPKPPLVSLDMSTAGCPVDRSFARDI 484

  Fly   521 WV-------DEEQVFPLYRLSYHWINPIGVATVIVVGALVS 554
            ::       :||..|.|||:||.|...:|.......|.|:|
  Fly   485 FLKTVIAVAEEEHYFYLYRISYMWYAALGFLITFFGGWLLS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	203/559 (36%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	203/559 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448268
Domainoid	1	1.000	233	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900