DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and Slc5a1

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_037165.1	Gene:	Slc5a1 / 25552	RGDID:	3713	Length:	665	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	115/567 - (20%)
Similarity:	217/567 - (38%)	Gaps:	111/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YLLGSRNLKVFPVAMSLIASYIS-----GVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYI 132
            :.|..|::..:|:..||.||.|.     |:...|..:.|...|.: |...:.:::.|    ::::
  Rat    58 FFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFE-WNALVFVVVLG----WLFV 117

  Fly   133 PVFSALQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFI-----VYVPAIALNQVSGINLHV 192
            |::....|.:..|||..||..  :.|..::.:|..:|:: |.     ::..||.:|...|:::::
  Rat   118 PIYIKAGVVTMPEYLRKRFGG--KRIQIYLSVLSLLLYI-FTKISADIFSGAIFINLALGLDIYL 179

  Fly   193 IAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIF 257
            ...:::.:...||..||:.||::||..|..:|.:....:...|.....|.....|...|....:.
  Rat   180 AIFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFREVGGYEAFMDKYMKAIPTLV 244

  Fly   258 NNTN------------------PSPYVRHTVWSVLIGGFS-----YWTSFNAVNQTMVQRYMSLP 299
            ::.|                  ..|......|..||.|.|     ||    ..:|.:|||.:|..
  Rat   245 SDGNITVKEECYTPRADSFHIFRDPITGDMPWPGLIFGLSILALWYW----CTDQVIVQRCLSAK 305

  Fly   300 SLKKARAS---------MAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPLSAGLITHDDQLLPLFV 355
            ::...:|.         :.:|.:.:...:|...|...:...:..:|.......:...:...|..|
  Rat   306 NMSHVKAGCTLCGYLKLLPMFLMVMPGMISRILYTDKIACVLPSECKKYCGTPVGCTNIAYPTLV 370

  Fly   356 VQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERASTILVKSTVIV 420
            |:.:.:  |:.||.::.:..:.:|||:.:.||.|.:...||..   |::.......:::...:.:
  Rat   371 VELMPN--GLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYT---KIRKGASEKELMIAGRLFI 430

  Fly   421 LGFVALSLVFV----LEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALL 481
            |..:.:|:.:|    ..|...:.....|:|:........:|.|.:.....|..| |..|:....|
  Rat   431 LVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPG-AFWGLILGFL 494

  Fly   482 AGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQVFPLYRLSYHWIN------P 540
            .|.....|:|....|            .|:            |....|......|::.      .
  Rat   495 IGISRMITEFAYGTG------------SCM------------EPSNCPKIICGVHYLYFAIILFA 535

  Fly   541 IGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPKECFSGRN 587
            |.|.||:|    :||:|||.           |.:|  |.:.|:|.||
  Rat   536 ISVVTVLV----ISLLTKPI-----------PDVH--LYRLCWSLRN 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	104/534 (19%)
Slc5a1	NP_037165.1	SLC5-6-like_sbd	27..665	CDD:382020	115/567 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340237
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750