DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and Slc5a11

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_666310.1	Gene:	Slc5a11 / 233836	MGIID:	1919316	Length:	673	Species:	Mus musculus

Alignment Length:	547	Identity:	116/547 - (21%)
Similarity:	207/547 - (37%)	Gaps:	113/547 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAVAKKGMENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF 65
            :||..:|.||     ..|.||.:...:...:.|::                  .|...||
Mouse    16 LEAFPQKSME-----PADIAVLVLYFLFVLAVGLW------------------STVRTKR----- 52

  Fly    66 GSEKMSEYLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQG----IA 126
              :.:..|.|...::..:||..||.||.:.....:|....    |........|..|.|    :.
Mouse    53 --DTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGS----GAAVGISVAAYELNGLFSVLM 111

  Fly   127 VSYVYIPVFSALQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIV--YVPAIALNQVSGIN 189
            :::|::|::.|.||.:..|||..||.....||...:..|...:|....|  |..||.:.|...::
Mouse   112 LAWVFLPIYIAGQVTTMPEYLRRRFGGNRISITLAVLYLFIYIFTKISVDMYAGAIFIQQSLHLD 176

  Fly   190 LHVIAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDD---AAK 251
            |::..|.::.:...||..||:.||::|||.|.::|.:....:...:.....|:..|.|.   |..
Mouse   177 LYLAIVGLLAITALYTVAGGLAAVIYTDALQTVIMLIGAFILMGYSFAAVGGMEGLKDQYFLALA 241

  Fly   252 GGRLIFNNTNPS--------------PYVRHTVWSVLIGGFS-----YWTSFNAVNQTMVQRYMS 297
            ..|    :.|.|              |......|..::.|.|     ||    ..:|.:|||.::
Mouse   242 SNR----SENSSCGLPREDAFHIFRDPLTSDLPWPGILFGMSIPSLWYW----CTDQVIVQRSLA 298

  Fly   298 LPSLKKARAS--MAIFTIGVAAFVSVCCYVGLLIYEMYKD---------CDPLSAGLITHDDQLL 351
            ..:|..|:..  ||.:...:..|:.|  :.|::...::.|         |..:.:......|...
Mouse   299 AKNLSHAKGGSLMAAYLKVLPLFLMV--FPGMVSRVLFPDQVACAHPDICQRVCSNPSGCSDIAY 361

  Fly   352 PLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERASTILVKS 416
            |..|::.:.  .|:.||.:|.:..|.:|||:.:.||.|.:...|:..   .::|......:::..
Mouse   362 PKLVLELLP--TGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWN---HIRPRASERELMIVG 421

  Fly   417 TVIVLGFVALSLVFV--------------LEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWAN 467
            .:.|...|.:|::::              ::.:|..|....:|          :|.:|......|
Mouse   422 RIFVFALVLVSILWIPIVQASQGGQLFIYIQSISSYLQPPVAM----------VFIMGCFWKRTN 476

  Fly   468 TVGTAVGGIASALLAGWISFGTQFTIA 494
            ..| |..|:...||.|.:.....|..|
Mouse   477 EKG-AFSGLILGLLLGLVRLILDFVYA 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	111/531 (21%)
Slc5a11	NP_666310.1	SLC5-6-like_sbd	28..673	CDD:382020	111/530 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750