DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus

Alignment Length:	582	Identity:	190/582 - (32%)
Similarity:	312/582 - (53%)	Gaps:	61/582 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF---GSEKMSEYLLGSRN 79
            ||.||.||:::|.:.|||:.                           |   |.:...::|:|.|:
Mouse    14 DYVVFAGMLLISAAIGIYYA---------------------------FAGGGQQTSKDFLMGGRS 51

  Fly    80 LKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSY 144
            :...|||:||.||::|.||:|||.:|:|.:|..:....|......:..:.|::|||..|.:.|:|
Mouse    52 MSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTY 116

  Fly   145 EYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVGG 209
            ||||:||:..:|...:.:||:..||:...::|.||:|||||:|.:|....|...|||.||..:||
Mouse   117 EYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGG 181

  Fly   210 IKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSVL 274
            :||||.||.:||.:|.....:|.|.|::..:|:|.:..||..||||.|.|.:|:|..|||.|:::
Mouse   182 LKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIV 246

  Fly   275 IGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPL 339
            |||...||:...|||:.||||:|..|...|:.|:.:..:|:...::...:.||.:|..|::|||.
Mouse   247 IGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPW 311

  Fly   340 SAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQ 404
            ::..::..|||:|..|:..:.:..|:.|||:|..:...||::|..:|:.:.|.:||:::..|| .
Mouse   312 TSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFK-S 375

  Fly   405 PSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTV 469
            .||::.:.:.:...::.|.:.:.:..:...:..:|....|:..:..|...|||:||:|||:||::
Mouse   376 LSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSI 440

  Fly   470 GTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQV------- 527
            |...|.:|...::.|:..|.|......| .:..||:...||  |:|...:.|:...::
Mouse   441 GALTGLLAGFAISLWVGIGAQLYPPLPE-RTLPLPLETYGC--NITHNGSDWMSTTEMPFSTSAF 502

  Fly   528 -------FPL----YRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFL 578
                   .||    |.|||.:.:.||..|.:.||.|:||.| ....:.|||        |||
Mouse   503 QIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLST-GGRKQNLDP--------RFL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	182/558 (33%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	184/566 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836530
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850