Protein Alignment SLC5A11 and Slc5a8

DIOPT Version :10

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_663398.2
• Gene: Slc5a8 / 216225
• MGIID: 2384916
• Length: 611
• Species: Mus musculus
• Alignment Length: 582
• Identity: 190/582 - (32%)
• Similarity: 312/582 - (53%)
• Gaps: 61/582 - (10%)

  Fly    18 DYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF---GSEKMSEYLLGSRN 79
            ||.||.||:::|.:.|||:.                           |   |.:...::|:|.|:
Mouse    14 DYVVFAGMLLISAAIGIYYA---------------------------FAGGGQQTSKDFLMGGRS 51

  Fly    80 LKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSY 144
            :...|||:||.||::|.||:|||.:|:|.:|..:....|......:..:.|::|||..|.:.|:|
Mouse    52 MSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTY 116

  Fly   145 EYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVGG 209
            ||||:||:..:|...:.:||:..||:...::|.||:|||||:|.:|....|...|||.||..:||
Mouse   117 EYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGG 181

  Fly   210 IKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSVL 274
            :||||.||.:||.:|.....:|.|.|::..:|:|.:..||..||||.|.|.:|:|..|||.|:::
Mouse   182 LKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIV 246

  Fly   275 IGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPL 339
            |||...||:...|||:.||||:|..|...|:.|:.:..:|:...::...:.||.:|..|::|||.
Mouse   247 IGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPW 311

  Fly   340 SAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQ 404
            ::..::..|||:|..|:..:.:..|:.|||:|..:...||::|..:|:.:.|.:||:::..|| .
Mouse   312 TSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFK-S 375

  Fly   405 PSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTV 469
            .||::.:.:.:...::.|.:.:.:..:...:..:|....|:..:..|...|||:||:|||:||::
Mouse   376 LSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSI 440

  Fly   470 GTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQV------- 527
            |...|.:|...::.|:..|.|......| .:..||:...||  |:|...:.|:...::
Mouse   441 GALTGLLAGFAISLWVGIGAQLYPPLPE-RTLPLPLETYGC--NITHNGSDWMSTTEMPFSTSAF 502

  Fly   528 -------FPL----YRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFL 578
                   .||    |.|||.:.:.||..|.:.||.|:||.| ....:.|||        |||
Mouse   503 QIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLST-GGRKQNLDP--------RFL 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	182/558 (33%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	184/566 (33%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q8N695	609..611