Protein Alignment SLC5A11 and slc-5A12

DIOPT Version :10

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_001041067.1
• Gene: slc-5A12 / 178127
• WormBaseID: WBGene00014092
• Length: 577
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 171/609 - (28%)
• Similarity: 282/609 - (46%)
• Gaps: 97/609 - (15%)

  Fly    17 VDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGSRNLK 81
            :|||:|...|.||.|||:|...  ||::.|...:.|                ...|||:|.|.|.
 Worm    10 LDYAIFGLSIGLSLSTGVYHAI--KSRIILRRGDRT----------------AKEEYLMGGRQLP 56

  Fly    82 VFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSYEY 146
            ..|||:||:.:::||:.:||..:|::..|.|.|...:..:...|...:|::|||..::....:||
 Worm    57 PLPVALSLLTTFLSGILMLGVPAEMFQRGAQIWLNFVIGVASSIVTCFVFLPVFHKMKSTCLHEY 121

  Fly   147 LEMRFHSV-VRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVGGI 210
            ...|::|: :|.:.|.:|:|..|:::..::|.|::||:.|..||...:.::.......||.:||:
 Worm   122 FIHRYNSILIRRLFSLLFLLFTIVYMSVVLYAPSVALSPVLQINKWYLVLIFGCTTTLYTCLGGL 186

  Fly   211 KAVVHTDAWQVLVMFLSVLAVAI--LATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVR------ 267
            ||||.||:.|.::|:..|..:..  |:.....||..:...|...||:       |...|
 Worm   187 KAVVWTDSLQAVIMYTGVFTLIYKGLSHPRVGGLERVLSIAWDSGRI-------SELGRMDWRID 244

  Fly   268 --HTVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVC---CYVGL 327
              :::|..|..|...|.:...|||..:|||.||||||.|: |:.|:|:  |.|..:|   .:||.
 Worm   245 QYNSLWINLFSGTIVWLASFGVNQLAIQRYASLPSLKVAQ-SIIIYTL--APFTVLCSIVAFVGF 306

  Fly   328 LIYEMYKDCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVI 392
            :....:.:|:||..|.:...|.:...|....:....|:.||:::.|..|.||:||..:||.:..|
 Worm   307 IALAYFYNCNPLETGEVKESDHITISFARDILQPTPGLFGLYVSCIMSATLSTLSSGMNSMAAAI 371

  Fly   393 LEDIVRGCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLF 457
            .||.::.....:.::..:|.|.|..|::.|..:..|.|:.|.|.|.|.||.|:....:|....:|
 Worm   372 YEDFLKNSLDGKITDTGATRLNKIIVLICGLSSTGLAFLAEVLGGSLRICISVMGAMSGPMVAIF 436

  Fly   458 TLGMLVPWANTVGTAVGGIASALLAGWIS--FGTQFTIA---AGELNSQKLP--VSVEGCVG--N 513
            .|.:..|        ..|..|.|::.::|  |.....||   ....:...||  .::|||.|  |
 Worm   437 VLALFFP--------KSGSKSCLISFFLSNLFCLIICIANYIQDPYHDLFLPTNTTLEGCNGNSN 493

  Fly   514 VTLRENIWVDEEQVFPLYRLSYHWINP---------------IGVATVIVVGALVSLVTKPTNMK 563
            .|:|         :.|.|  ..|:.||               :|...:|::|.:.||..:..:.
 Worm   494 FTIR---------MMPTY--DAHYGNPDTLYISRISTYSYAGVGFVLMIIIGWIASLFEESDHK- 546

  Fly   564 TLDPDLISPVIHRFLPKECFSGRN 587
                  :..:.|.     .|||||
 Worm   547 ------VEKIRHL-----TFSGRN 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	164/576 (28%)
slc-5A12	NP_001041067.1	SLC5sbd_NIS-SMVT	11..540	CDD:271383	164/575 (29%)