Protein Alignment SLC5A11 and SLC5A8

DIOPT Version :9

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 206/607 - (33%)
• Similarity: 319/607 - (52%)
• Gaps: 70/607 - (11%)

  Fly    18 DYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF---GSEKMSEYLLGSRN 79
            ||.||.||:|:|.:.|||:.                           |   |.:...::|:|.|.
Human    14 DYVVFAGMLVISAAIGIYYA---------------------------FAGGGQQTSKDFLMGGRR 51

  Fly    80 LKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSY 144
            :...|||:||.||::|.||:|||.||:|.:|..:...|.......:..:.|::|||..|.:.|:|
Human    52 MTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTY 116

  Fly   145 EYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVGG 209
            ||||:||:..||...:.:||:..||:...::|.||:|||||:|.:|....|...|||.||..:||
Human   117 EYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGG 181

  Fly   210 IKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSVL 274
            :|||:.||.:||.:|.....:|.|.|.|...|::.:.:||..||||.|.|.||:|..|||.|:::
Human   182 LKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTII 246

  Fly   275 IGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPL 339
            |||...|||...|||:.||||:|..|..:|:.|:.|..:|:.|.::...:.||.:|..|.||||.
Human   247 IGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPW 311

  Fly   340 SAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQ 404
            :|..::..|||:|..|:..:....|:.|||:|..:...||::|..:|:.:.|.:||:::..|: .
Human   312 TAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFR-S 375

  Fly   405 PSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTV 469
            .|||:.:.:.:...:|.|.:.:.:..:...:..:|....|:..:..|...|||.||:|||:||::
Human   376 LSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSI 440

  Fly   470 GTAVGGIASALLAGWISFGTQFTIAAGELNSQKLP--VSVEGCVGNVTLRE-NIWVDEEQVF--- 528
            |..||.:|...::.|:..|.|.   ...|..:.||  :.::||  |.|..| |:....|..|
Human   441 GALVGLMAGFAISLWVGIGAQI---YPPLPERTLPLHLDIQGC--NSTYNETNLMTTTEMPFTTS 500

  Fly   529 ----------PL----YRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLP 579
                      ||    |.|||.:.:.:|....::||.||||.| ....:.|||..|       |.
Human   501 VFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLST-GGRKQNLDPRYI-------LT 557

  Fly   580 KECFSG------RNLHAQAHKN 595
            ||.|..      :..|..::|:
Human   558 KEDFLSNFDIFKKKKHVLSYKS 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	194/560 (35%)
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	196/568 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850