DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and SLC5A12

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_848593.2	Gene:	SLC5A12 / 159963	HGNCID:	28750	Length:	618	Species:	Homo sapiens

Alignment Length:	588	Identity:	186/588 - (31%)
Similarity:	308/588 - (52%)	Gaps:	53/588 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEY 73
            ||...|...||.||..:..:|:..|::|...::.|.                        ...|:
Human     1 MEVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKA------------------------TSREF 41

  Fly    74 LLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSAL 138
            |:|.|.:...||.:||.||::|.||:|||.||:|.:|..:....||.:...:..|.:::|||...
Human    42 LVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRS 106

  Fly   139 QVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVF 203
            .:.|:||||::||:..||..|:.::|:..||:...:||.||:|||||:|.:|........:||.|
Human   107 GITSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTF 171

  Fly   204 YTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRH 268
            |..:||:||||.|||:|::||.:..|.|.|..:.:|.|.:.:.:.:..|.||...:.:..|..||
Human   172 YCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRH 236

  Fly   269 TVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMY 333
            |.|::.:||...|.....|||:.:||.:|..:.|.|:.::....:|:...:....:.||::|..:
Human   237 TFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHF 301

  Fly   334 KDCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVR 398
            |||||.::|:|:..|||:|.||::....:.|:.|||:|..|...||:::..:|:.:.|..||.|:
Human   302 KDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVK 366

  Fly   399 GCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLV 463
            .||. ..|::.||.:.|...::.|.:..|:......:.|::....|:..:..|...|||:||::.
Human   367 SCFP-HLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVF 430

  Fly   464 PWANTVGTAVGGIASAL-LAGWISFGTQFTIAAGELNSQKLPVSVEGCV-GNVTL--------RE 518
            |:.|..| |:||:.:.: |:.|::.|. |...|....:..||:|.:.|: .|||.        |.
Human   431 PFVNWKG-ALGGLLTGITLSFWVAIGA-FIYPAPASKTWPLPLSTDQCIKSNVTATGPPVLSSRP 493

  Fly   519 NI---WVDEEQVFPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPK 580
            .|   |         |.:||.:.:.:|....||.|.::||:|.....:.:.|.||.||.:.|
Human   494 GIADTW---------YSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLF--- 546

  Fly   581 ECF 583
             ||
Human   547 -CF 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	173/551 (31%)
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	175/559 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850