Protein Alignment SLC5A11 and SLC5A11

DIOPT Version :10

• Sequence 1: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 129/620 - (20%)
• Similarity: 238/620 - (38%)
• Gaps: 151/620 - (24%)

  Fly     1 MEAVAKKGMENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF 65
            ::|..:||:|.   |.:...|...:.||  :.|::                    :|.|.::
Human    16 LDAFPQKGLEP---GDIAVLVLYFLFVL--AVGLW--------------------STVKTKR--- 52

  Fly    66 GSEKMSEYLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQG----IA 126
              :.:..|.|...::..:||..||.||.:.....:|....    |........|..|.|    :.
Human    53 --DTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGS----GAATGISVSAYELNGLFSVLM 111

  Fly   127 VSYVYIPVFSALQVGSSYEYLEMRFHS-----VVRSIASFMFILDEILFLPFIVYVPAIALNQVS 186
            ::::::|::.|.||.:..|||..||..     ::..:..|::|..:|   ...:|..||.:.|..
Human   112 LAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAVLYLFIYIFTKI---SVDMYAGAIFIQQSL 173

  Fly   187 GINLHVIAVVIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAK 251
            .::|::..|.::.:...||..||:.||::|||.|.|:|.:..|.:            :.:..||.
Human   174 HLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTL------------MGYSFAAV 226

  Fly   252 GG----------RLIFNNTNPS---------------PYVRHTVWSVLIGGFS-----YWTSFNA 286
            ||          .|..|.:..|               |......|..::.|.|     ||    .
Human   227 GGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYW----C 287

  Fly   287 VNQTMVQRYMSLPSLKKAR--ASMAIFTIGVAAFVSVCCYVGLLIYEMYKD---------CDPLS 340
            .:|.:|||.::..:|..|:  |.||.:...:..|:.|  :.|::...::.|         |..:.
Human   288 TDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMV--FPGMVSRILFPDQVACADPEICQKIC 350

  Fly   341 AGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQP 405
            :......|...|..|::.:.  .|:.||.:|.:..|.:|||:.:.||.|.:...|:..   .::|
Human   351 SNPSGCSDIAYPKLVLELLP--TGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWN---HLRP 410

  Fly   406 SERASTILVKSTVIVLGFVALSLVFV----LEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWA 466
            ......:::...|.||..|.:|::::    ..|...:.....|:::........:|.:|......
Human   411 RASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRT 475

  Fly   467 NTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWV----DEEQV 527
            |..| |..|:.|.||.|.:.....|                            |:|    |:...
Human   476 NEKG-AFWGLISGLLLGLVRLVLDF----------------------------IYVQPRCDQPDE 511

  Fly   528 FPLYRLSYHWI---NPIGVATVIVVGALVSLVTKP 559
            .|:...|.|::   ..:...|:|.| :.||..|:|
Human   512 RPVLVKSIHYLYFSMILSTVTLITV-STVSWFTEP 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	122/599 (20%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	125/608 (21%)