DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	167/577 - (28%)
Similarity:	283/577 - (49%)	Gaps:	50/577 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGSR 78
            ||:.||.||..|:::||..|::.|..:.                        |.....::..|.|
  Rat    12 FGAWDYGVFATMLLVSTGIGLWVGLARG------------------------GQRSADDFFTGGR 52

  Fly    79 NLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSS 143
            .|...||.:||.||::|.|.:||..:|...||.::.::....:|..:..:::::|:|..|.:.|:
  Rat    53 QLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTST 117

  Fly   144 YEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVG 208
            |:|||:||...||...:..:::..:|:...::|.||:.||||:|:::....:...::|..||.||
  Rat   118 YQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVG 182

  Fly   209 GIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSV 273
            |:||||.||.:||:||.:....:.....:...|...:...|....|:...:.:|.|..|:|.|:.
  Rat   183 GMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTF 247

  Fly   274 LIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFV--SVCCYVGLLIYEMYKDC 336
            ::||...|.|...|||..||||::..:..||:.::.:..:|:...|  :.||  |::::..||||
  Rat   248 IVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACC--GIVMFVYYKDC 310

  Fly   337 DPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCF 401
            |||..|.|:..||.:||.|:.....:.|:.|||:|..:...||:.|..:|:.:.|.:||:::
  Rat   311 DPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK--- 372

  Fly   402 KMQP--SERASTILVKSTVIVLGFVALSLVFVLEQL-SGILSICTSMTAIAAGTTFGLFTLGMLV 463
            ...|  :.|....:.|....:.|...|::..:...| .|:|....::..:.:|...|.||||||:
  Rat   373 PRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLL 437

  Fly   464 PWANTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVG-NVTLRENIWVDEEQV 527
            |..||.|...|..|...::.|::.|... ...||.....||.|..||.. :|.|......:....
  Rat   438 PACNTPGVLSGLAAGLAVSLWVAVGATL-YPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNG 501

  Fly   528 FP--------------LYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLI 570
            .|              .|.:||.:...:|..|.::.|||:|.:|.||...:|.|.|:
  Rat   502 IPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	159/558 (28%)
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	161/563 (29%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340205
Domainoid	1	1.000	44	1.000	Domainoid score	I11950
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850