DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and Slc5a3

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_446167.2	Gene:	Slc5a3 / 114507	RGDID:	621530	Length:	718	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	121/552 - (21%)
Similarity:	209/552 - (37%)	Gaps:	114/552 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MSEYLLGSRNLKVFPVAMSLIASYISGVTILGT--TSEIYNYGTQYWFIAIAIMLQGIAVSYVYI 132
            :|.|.|..|::....:..||..|.|.....:|.  :.....:....|.....::||  .:.:|:|
  Rat    36 VSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQ--LLGWVFI 98

  Fly   133 PVFSALQVGSSYEYLEMRF--HSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAV 195
            |::....|.:..|||..||  |.:....|:...:|.....|...:|..|:.:.:..|.||:|..:
  Rat    99 PIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVI 163

  Fly   196 VIVVVCVFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLI---- 256
            :::.:....|..||:.||::||..|.|:|.:..|.:.:::.:...|    |::..:...|.
  Rat   164 LLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMMKVGG----FEEVKRRYMLASPNV 224

  Fly   257 --------FNNTNP--------------SPYVRHTVWSVLIGGFS-----YWTSFNAVNQTMVQR 294
                    .:|||.              .|......|...|.|.:     ||    ..:|.:|||
  Rat   225 ASILLTHNLSNTNSCMVHPKADALKMLRDPTDEDVPWPGFILGQTPASVWYW----CADQVIVQR 285

  Fly   295 YMSLPSLKKARAS---------MAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPLSAGLITHDDQL 350
            .::..::..|:.|         :.:|.|.|...:|...:|..:.....:.|..:........:..
  Rat   286 VLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFVDDIACINPEHCMQVCGSRAGCSNIA 350

  Fly   351 LPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERAS-TILV 414
            .|..|::.|.  .|:.||.:|.:..|.:|.|..:.||.|.:...|:    :|:..:..:| .:::
  Rat   351 YPRLVMELVP--VGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDV----YKLLRNNASSRELMI 409

  Fly   415 KSTVIVLGFVALSLVFV---LEQLSG-----ILSICTSMTAIAAGTTFGLFTLGMLVPWANTVGT 471
            ...:.|...|.:|:.:|   :|...|     |..:...:|...|    .||.|.:.....|..|.
  Rat   410 VGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVA----ALFLLAIFWKRCNEQGA 470

  Fly   472 AVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQVFPLYRLSYH 536
            ..||:|..:| |.|.....||..|.|            |            |:....|.:....|
  Rat   471 FYGGMAGFVL-GAIRLILAFTYRAPE------------C------------DQPDNRPSFIKDIH 510

  Fly   537 ---------WINPIGVATVIVVGALVSLVTKP 559
                     ||.  |:.|||     |||:|.|
  Rat   511 YMYVATALFWIT--GLITVI-----VSLLTPP 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	118/547 (22%)
Slc5a3	NP_446167.2	SLC5sbd_SMIT	9..718	CDD:271382	121/552 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010