DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC5A11 and LOC100488353

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_002936886.2	Gene:	LOC100488353 / 100488353	-ID:	-	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	182/565 - (32%)
Similarity:	300/565 - (53%)	Gaps:	50/565 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGSR 78
            |...||.||..::::|...|||:                   ....|||:     ...|:|.|.|
Frog    10 FSPWDYVVFAAVLLISAVIGIYY-------------------AFAGRRKN-----TSQEFLTGGR 50

  Fly    79 NLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSS 143
            ::...|||:||.||::|.||:|||.:::|.:|..|...|.:.:...|..:.:::|||..|.:.|:
Frog    51 SMSALPVALSLTASFMSAVTVLGTPADVYRFGAIYSMFAFSYVFVVIICAEIFLPVFYRLNITST 115

  Fly   144 YEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVG 208
            |||||:||:..||.:.:.:||::.:|:...::|.||:|||||||.||........:||.||..:|
Frog   116 YEYLELRFNKCVRILGTVIFIIEMVLYTGIVIYAPALALNQVSGFNLWGAMTATGLVCTFYCTLG 180

  Fly   209 GIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSV 273
            |||||:.||.:|:::|....:||.|...|...|:..:.:|:..||||.|.:.:|.|..|||.|::
Frog   181 GIKAVIWTDVFQIVIMVAGFIAVIIRGVVVQGGIQTIINDSYYGGRLNFWDFDPQPLRRHTFWTI 245

  Fly   274 LIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDP 338
            :|||...|.....|||:.||||:|..:..:|:.|:.|..||:...::.....||::|.:||||||
Frog   246 VIGGTFLWVGIYGVNQSQVQRYISCKTKGQAKLSLYINLIGLMIILACAVLCGLILYSVYKDCDP 310

  Fly   339 LSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKM 403
            .::.:|:..|||:|..|:..:....|:.|||:|..:...||::|..:|:.:.|.:||:::....:
Frog   311 WTSQIISAPDQLMPYLVLDILQGYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYTHL 375

  Fly   404 QPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANT 468
              ||...:.:.|....:.|.:.:::..|...:..::....|:.|:..|...|||:||:..|:.|:
Frog   376 --SENKLSWISKGMSALYGILCIAMAAVASFMGSVIQAALSIFAMVGGPLLGLFSLGLFFPFCNS 438

  Fly   469 VGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVD---------E 524
            ||..||.:....::.|...|.|......| .|:.||:|:.||  |.:..:..|..         .
Frog   439 VGAIVGLLFGFSMSLWAGIGAQIYPPLPE-RSRPLPLSIAGC--NFSTMDTNWTSMTTEPTMAMV 500

  Fly   525 EQVFPL------------YRLSYHWINPIGVATVIVVGALVSLVT 557
            ..:.||            |.|||.:.:.:|....|:||.:|||::
Frog   501 TNLIPLDTSERPVLADYWYSLSYLYFSTLGTIVTILVGVIVSLMS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	180/559 (32%)
LOC100488353	XP_002936886.2	SLC5-6-like_sbd	10..550	CDD:382020	182/565 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020