DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and slc5a8

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_021331097.1	Gene:	slc5a8 / 100329285	ZFINID:	ZDB-GENE-141211-63	Length:	609	Species:	Danio rerio

Alignment Length:	616	Identity:	193/616 - (31%)
Similarity:	303/616 - (49%)	Gaps:	88/616 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEY 73
            |.:..|...||.||:.|:.:||..|:|:....:|:                        ...:::
Zfish     3 MSSAVFSVWDYVVFIMMLAVSTGIGVYYAFAARSQ------------------------SSSADF 43

  Fly    74 LLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSAL 138
            |:..|:|...|||:||.||::|.:|:|||..|:|.||..:..|..|........|.:::|||..|
Zfish    44 LVAGRSLSAPPVALSLTASFMSAITVLGTPVEVYKYGAIFILICFAYAFMVALSSEIFLPVFYRL 108

  Fly   139 QVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVF 203
            .|.|:|                      |:|:...::|.||:|||||:|::|....:...|||..
Zfish   109 GVTSTY----------------------EVLYTGLVIYAPALALNQVTGVDLWGAVISTGVVCTL 151

  Fly   204 YTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRH 268
            |..:||:||||.||.:||.:|...:|||.:.:.:...|:..:..|:|.|||:...:.:|:|..||
Zfish   152 YCTLGGLKAVVWTDVFQVGIMLAGLLAVIVQSVLLQGGIPRIISDSAHGGRINLWDFDPNPLRRH 216

  Fly   269 TVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIF----TIGVAAFVSVCCYVGLLI 329
            |.||:.:||..|||||..:|...||||:|..||  ..|.||:|    |:.|..|.:|.|  ||.:
Zfish   217 TFWSITVGGTFYWTSFYGINHAQVQRYISCKSL--IHAKMALFINLVTLWVVTFCAVFC--GLCL 277

  Fly   330 YEMYKDCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAAL-----SSLSVVLNSTS 389
            |.:||:|||..|..::..|||:|..|:..:....|:.|||:|..:....     |::|..:|:.:
Zfish   278 YSVYKNCDPWMAKKVSAQDQLMPYLVLDILSEFPGLPGLFVAAAYSGTFMFIVNSTVSSSVNALA 342

  Fly   390 LVILEDIVRGCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTF 454
            .|.:.|::|....:  ||:..:...|:..:..|.|.:.:..:...:.|:|....|::.:..|...
Zfish   343 AVTVTDVLRPYLSL--SEKQLSWASKAMSLFYGAVCIGMAGIASMMGGMLQAAFSISGVIGGPLL 405

  Fly   455 GLFTLGMLVPWANTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGC-------VG 512
            |||:|.:|.|.||:.|...|.::...|:.|:..|.|......| ||:.|.::..||       ..
Zfish   406 GLFSLAILFPCANSKGGLAGLVSGLGLSLWVCIGAQIYPPPAE-NSRPLTLNTHGCNLSMAPDTT 469

  Fly   513 NVTLRENIWVDEEQVF--PL-----YRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLI 570
            |.|...:|:..||:..  ||     |.|||.:...:|..|.|.||.:||:::....|| |.|.|.
Zfish   470 NWTASMDIYRIEEETLERPLLADNWYSLSYLYFGLLGTVTAIAVGLIVSILSGGQRMK-LQPGLT 533

  Fly   571 SPVIHRFLPKE---CFSG-RNLHAQAHKNLL 597
                   |.||   |:.. :.|.|:...:||
Zfish   534 -------LSKEDLTCYKAYKILKAKVSTHLL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	178/561 (32%)
slc5a8	XP_021331097.1	SLC5-6-like_sbd	6..527	CDD:320982	179/573 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950