DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A11 and slc5a10

DIOPT Version :9

Sequence 1:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_017211446.2	Gene:	slc5a10 / 100007379	ZFINID:	ZDB-GENE-110922-5	Length:	637	Species:	Danio rerio

Alignment Length:	596	Identity:	129/596 - (21%)
Similarity:	238/596 - (39%)	Gaps:	124/596 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEYLLGSR 78
            |...|..|.....:|:.:.||:..| :.|:                        ..:|.|.|..|
Zfish    16 FSVSDIIVIGAYFLLNVAVGIWSSC-RVSR------------------------NTLSGYFLAGR 55

  Fly    79 NLKVFPVAMSLIAS-----YISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSAL 138
            ::..:|:..||.||     ...|:...|....|...|.: |....|:    :|:::|::||:.:.
Zfish    56 DMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFE-WNATYAL----LALAWVFVPVYVSS 115

  Fly   139 QVGSSYEYLEMRF--HSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVC 201
            .:.:..|||..||  ..:...:::...:|.....:...:|..|:.:....|.||::..|:::||.
Zfish   116 GIVTMPEYLGRRFGGERIRMYLSALSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLVVT 180

  Fly   202 VFYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILA----TVYANGLNVLFDDAAKGGRLIFNNTNP 262
            ..||..||:.||::||..|..:|.:..:.:.|.|    ..|:|..:|...  |...::|.|.|..
Zfish   181 ALYTIAGGLAAVIYTDTLQTFIMIIGAVILTITAFNKIGGYSNLESVYLQ--AVPSKIIPNTTCH 243

  Fly   263 SPYVRHTV-------------WSVLIGGFS-----YWTSFNAVNQTMVQRYMSLPSLKKARASMA 309
            .|  ||..             |..:..|.:     ||    ..:|.:|||.:|..||..|:.: :
Zfish   244 LP--RHDAMHLFRDPVHGDLPWPGMTLGLTIIATWYW----CTDQVIVQRSLSAKSLSHAKGA-S 301

  Fly   310 IFTIGVAAFVSVCCYV-----GLLIYEMYKD---------CDPLSAGLITHDDQLLPLFVVQSVG 360
            ||    |:::.:...:     |::...:|.|         |..:....:...:...|..|::.:.
Zfish   302 IF----ASYLKLLPMMFIILPGMISRALYPDTVACVDPEECVKVCGAEVGCSNIAFPKLVIELMP 362

  Fly   361 HIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQPSERASTILVKSTVIVLGFVA 425
            .  |:.||.||.:..|.:|||:.:.||:|.:...||.:. ::...||:...::.:...::|..::
Zfish   363 S--GLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWKK-YRRGASEKELLLVGRIVTVILVVIS 424

  Fly   426 LSLVFVLEQL-SGILSI-CTSMTAIAAGTTFGLFTLGMLVPWANTVGTAVGGIASALLAGWISFG 488
            :..:.:|:.. ||.|.: ..|:|:..|.....:|.:.:.....|..| |..|:...|:.|.....
Zfish   425 VVWIPILQSANSGQLYVYIQSVTSYLAPPVTAIFVMAVFWKRTNEAG-AFWGLMVGLVVGLTRMV 488

  Fly   489 TQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQVF---PLYRLSYHWIN--PIGVATVIV 548
            .:|........                           ||   |....|.|:::  .|..|...:
Zfish   489 LEFAFPPPRCG---------------------------VFDPAPSVLRSMHYLHFAIILCALTAI 526

  Fly   549 VGALVSLVTKP 559
            |.|::||:|.|
Zfish   527 VVAVISLLTPP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	125/588 (21%)
slc5a10	XP_017211446.2	SLC5sbd_SGLT5	17..637	CDD:212058	128/595 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750