DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGAP5 and MPPE1

DIOPT Version :9

Sequence 1:	NP_609191.1	Gene:	PGAP5 / 34116	FlyBaseID:	FBgn0031997	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	XP_006722403.1	Gene:	MPPE1 / 65258	HGNCID:	15988	Length:	397	Species:	Homo sapiens

Alignment Length:	357	Identity:	149/357 - (41%)
Similarity:	213/357 - (59%)	Gaps:	24/357 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LYACFVIVLCALIFCEYVADFVVLQKCKWPEIKR-----KKYVDDP-LRAMILADPHLLGPHRGH 62
            |.....:|...|:|||::..::.:.:|.|||:|.     ::...:| |:||.|||.||||...||
Human    23 LLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGH 87

  Fly    63 WLDKLYREWHMTRAFQAASRLFQPDVVFVLGDLFDEGDMVSDKQFQEYVWRYLKMFHLPPGIPLI 127
            |||||.|||.|.||||.|..|.||:|||:|||:||||...:.:.:.:.|.|:.|||..|..:.|.
Human    88 WLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLK 152

  Fly   128 SVAGNHDVGFHYKMHPFFMSRFESYLNNSSVNLYTIKQIHFVVINSMAMEGDGCMFCTQAEDQLK 192
            .||||||:||||:|:.:.:.|||...  ||..|::.|.|:||::||:|:.||||..|::.|.:|.
Human   153 VVAGNHDIGFHYEMNTYKVERFEKVF--SSERLFSWKGINFVMVNSVALNGDGCGICSETEAELI 215

  Fly   193 NISRTLYCMKYPL--EAECARTRRHPYSQPILLQHFPTYRISDTMC--------EEHDAPYIEAF 247
            .:|..|.|.:...  .:.|......|.|.|:||||:|.||.||..|        ||.|.|    |
Human   216 EVSHRLNCSREQARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIP----F 276

  Fly   248 RERFHVLSKDATDMLGELLKPRLAFAGHSHHFCHSVNRLGIDEYTVASFSWRNKVNPSFMLATIT 312
            :|.:.|||::|:..|...|:|||..:||:|..|...:...:.|.:|.||||||:.||||::.:||
Human   277 KENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSIT 341

  Fly   313 PDDYVVSKCKMLPQQFVFNSYLSAGILCLIVI 344
            |.||.:|||.:..:..|...|  .|::..:|:
Human   342 PTDYTLSKCYLPREDVVLIIY--CGVVGFLVV 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP5	NP_609191.1	Metallophos	45..279	CDD:278574	112/243 (46%)
PGAP5	NP_609191.1	MPP_MPPE1	48..301	CDD:277372	118/262 (45%)
MPPE1	XP_006722403.1	Metallophos	70..306	CDD:278574	111/241 (46%)
MPPE1	XP_006722403.1	MPP_MPPE1	73..330	CDD:277372	118/262 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146552
Domainoid	1	1.000	209	1.000	Domainoid score	I2852
eggNOG	1	0.900	-	-		E1_KOG3662
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41512
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2950
Isobase	1	0.950	-	0	Normalized mean entropy	S3042
OMA	1	1.010	-	-		QHG59236
OrthoDB	1	1.010	-	-		D1094620at2759
OrthoFinder	1	1.000	-	-		FOG0003247
OrthoInspector	1	1.000	-	-		oto91497
orthoMCL	1	0.900	-	-		OOG6_104282
Panther	1	1.100	-	-	LDO	PTHR13315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1923
SonicParanoid	1	1.000	-	-		X4869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750