DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PGAP5 and Mppe1

DIOPT Version :9

Sequence 1:	NP_609191.1	Gene:	PGAP5 / 34116	FlyBaseID:	FBgn0031997	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	XP_011245209.1	Gene:	Mppe1 / 225651	MGIID:	2661311	Length:	420	Species:	Mus musculus

Alignment Length:	372	Identity:	158/372 - (42%)
Similarity:	223/372 - (59%)	Gaps:	39/372 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VIVLCALIFCEYVADFVVLQKCKWPEIK------RKKYVDDPLRAMILADPHLLGPHRGHWLDKL 67
            |:::..|:||||...::||.:|.|||:|      |::.|   |:||.|||.||||..||||||||
Mouse    29 VVIISVLLFCEYFIYYLVLFRCHWPEVKTLAHGGRQEPV---LKAMFLADTHLLGEIRGHWLDKL 90

  Fly    68 YREWHMTRAFQAASRLFQPDVVFVLGDLFDEGDMVSDKQFQEYVWRYLKMFHLPPGIPLISVAGN 132
            .|||.|.||||.|..|.||:|||:|||:||||...||:.:.:.|.|:.:||.....:.|..|.||
Mouse    91 RREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSSDQAWADDVQRFQRMFRHDSHVQLKVVIGN 155

  Fly   133 HDVGFHYKMHPFFMSRFESYLNNSS-VNLYTIKQ-------------------IH-FVVINSMAM 176
            |||||||:|..:.:.|||....:.. ::|..:||                   :| ||::||:||
Mouse   156 HDVGFHYQMSKYRIKRFEKVFGSERLLSLKGVKQDLSMLPLQRQTPELGLYPHLHSFVMVNSVAM 220

  Fly   177 EGDGCMFCTQAEDQLKNISRTLYCM--KYPLEAECAR--TRRHPYSQPILLQHFPTYRISDTMCE 237
            |||||:.|::.|.:|:.|||.|.|.  :.|..::|.|  ..|.|.|.|:||||:|.||.||..|.
Mouse   221 EGDGCIICSEEEAELREISRKLNCSQEQVPGSSQCDREPEPRLPLSAPVLLQHYPLYRASDANCS 285

  Fly   238 EHDAPYIE----AFRERFHVLSKDATDMLGELLKPRLAFAGHSHHFCHSVNRLGIDEYTVASFSW 298
            ..||...|    .|.|::.|||::|:..|...|:|||..:||:|..|..::..|..|.:|.||||
Mouse   286 GEDAAPPEERNVPFEEKYDVLSREASQKLLWWLRPRLVLSGHTHSACEVLHPGGAPEVSVPSFSW 350

  Fly   299 RNKVNPSFMLATITPDDYVVSKCKMLPQQFVFNSY-LSAGILCLIVI 344
            ||:.||||::.::|..||.:|||.:..:..|...| .:||.|.::::
Mouse   351 RNRNNPSFIMGSLTSRDYALSKCYLPFEDTVLTMYGAAAGFLMILIL 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP5	NP_609191.1	Metallophos	45..279	CDD:278574	118/262 (45%)
PGAP5	NP_609191.1	MPP_MPPE1	48..301	CDD:277372	125/281 (44%)
Mppe1	XP_011245209.1	MPP_MPPE1	71..353	CDD:277372	125/281 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836652
Domainoid	1	1.000	220	1.000	Domainoid score	I2613
eggNOG	1	0.900	-	-		E1_KOG3662
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41512
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2725
Isobase	1	0.950	-	0	Normalized mean entropy	S3042
OMA	1	1.010	-	-		QHG59236
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003247
OrthoInspector	1	1.000	-	-		oto95080
orthoMCL	1	0.900	-	-		OOG6_104282
Panther	1	1.100	-	-	LDO	PTHR13315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1923
SonicParanoid	1	1.000	-	-		X4869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740