DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGAP5 and mppe1

DIOPT Version :9

Sequence 1:	NP_609191.1	Gene:	PGAP5 / 34116	FlyBaseID:	FBgn0031997	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	XP_002936127.1	Gene:	mppe1 / 100492787	XenbaseID:	XB-GENE-987928	Length:	399	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	161/374 - (43%)
Similarity:	225/374 - (60%)	Gaps:	14/374 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FLYACFVIVLCALIFCEYVADFVVLQKCKWPEIK--RKKYVDDPLRAMILADPHLLGPHRGHWLD 65
            ||.:.|..:|....|||::..::|:.||.|||:|  .|:.....|:||.|||.||||..||||.|
Frog    27 FLCSIFGSILLVFFFCEFLVYYLVIVKCSWPEVKGAHKEDSTPVLKAMFLADTHLLGEIRGHWFD 91

  Fly    66 KLYREWHMTRAFQAASRLFQPDVVFVLGDLFDEGDMVSDKQFQEYVWRYLKMFHLPPGIPLISVA 130
            ||.|||.|.|::|:|..|.||||||:|||:||||.....:.:...|.|:.|||..||...||.:.
Frog    92 KLRREWQMERSYQSALWLLQPDVVFILGDIFDEGKWSIPEAWSRDVVRFQKMFRHPPHTELIVLV 156

  Fly   131 GNHDVGFHYKMHPFFMSRFESYLNNSSVNLYTIKQIHFVVINSMAMEGDGCMFCTQAEDQLKNIS 195
            ||||:||||.|:.:.:||||...|.:|..|.::|.|:||::||:|:|||.|..|..||:||:.||
Frog   157 GNHDIGFHYDMNIYKLSRFEKTFNFTSGKLVSLKGINFVLLNSVALEGDDCDICRAAENQLERIS 221

  Fly   196 RTLYCMK---YP-LEAECARTRRHPYSQPILLQHFPTYRISDTMCEEHDAPYIE----AFRERFH 252
            ..|.|.:   :| ...:|....:.|.|.||||||:|.||.||..|...|:...|    .|||::.
Frog   222 TKLSCSRMREHPDFRKKCKNVEKTPMSAPILLQHYPLYRFSDLECTGEDSASPEEKKVLFREKYD 286

  Fly   253 VLSKDATDMLGELLKPRLAFAGHSHHFCHSVNRLGIDEYTVASFSWRNKVNPSFMLATITPDDYV 317
            |||:||:..|.:||:|||..:||:|..|..:::..|.|.:|.||||||:.||||::.:||..:|.
Frog   287 VLSQDASKKLLQLLQPRLILSGHTHSACEVLHQGKIPEISVPSFSWRNRNNPSFIMGSITAANYS 351

  Fly   318 VSKCKMLPQQFVFNSYLSAGILCLIVIGFQLRKCIQSRRQSSAVDHRKV 366
            ::||.:..:..:...|.:.|.|....:...|..|...|..|.    ||:
Frog   352 LAKCFLPKENMIIYIYCTVGTLFTSYVLACLWACTIQRIHSG----RKI 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP5	NP_609191.1	Metallophos	45..279	CDD:278574	118/241 (49%)
PGAP5	NP_609191.1	MPP_MPPE1	48..301	CDD:277372	125/260 (48%)
mppe1	XP_002936127.1	MPP_MPPE1	74..335	CDD:277372	125/260 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2462
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41512
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2663
OMA	1	1.010	-	-		QHG59236
OrthoDB	1	1.010	-	-		D1094620at2759
OrthoFinder	1	1.000	-	-		FOG0003247
OrthoInspector	1	1.000	-	-		oto105266
Panther	1	1.100	-	-	LDO	PTHR13315
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080