DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8475 and phkb

DIOPT Version :9

Sequence 1:	NP_001260230.1	Gene:	CG8475 / 34114	FlyBaseID:	FBgn0031995	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_005166459.1	Gene:	phkb / 569706	ZFINID:	ZDB-GENE-110411-149	Length:	1087	Species:	Danio rerio

Alignment Length:	1080	Identity:	499/1080 - (46%)
Similarity:	711/1080 - (65%)	Gaps:	64/1080 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 KQLDIYYGIVKRQLLRYQSPITGLFPVMSTDQV-VGSVRDSVYCASAVWSLYQAYRRIDDDRGKS 112
            ::||.:|..||..:|.||||.||||||.:.... ...||||:|||:::|:|..||||||||.|::
Zfish    42 EKLDRFYSAVKSTILNYQSPTTGLFPVKTCSTCKEAKVRDSLYCAASIWALALAYRRIDDDMGRT 106

  Fly   113 YELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCVS 177
            :||..|.:||||||:.|:::|:.:||.|||..|....|||.|.:.||:::||.:.|||||||.:|
Zfish   107 HELEHSAIKCMRGIMYCYMRQSDKVENFKQDPSPSTCLHSIFNVDTGDEVYPYKEYNHLQIDALS 171

  Fly   178 LYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIGM 242
            |:||:||:||.|||||||..|||:|:||||:.||||||.|||||||||||||||:.|:|:||:|:
Zfish   172 LFLLYLVEMICSGLQIIYNTDEVSFIQNLVFCVERAYRVPDFGMWERGSKYNNGSTELHSSSVGL 236

  Fly   243 AKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAFA 307
            ||:|||||||.||||.:|.||||::||:|||||||....::|||||.|...|::||..:|:||||
Zfish   237 AKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNTDSALLPCISYPAFA 301

  Fly   308 SHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFIA 372
            ..:|.|..||...:|.:|:.|.|||||.||||.:.||||:||:|...|:|.|:|:|||:|:|:|.
Zfish   302 VDDDALYSQTLDKIVRKLKGKYGFKRFLRDGFRTANEDKNRRHYKPAEMKLFDGIECEFPIFYIY 366

  Fly   373 MIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYAPDGD---------GSYMRAPSQS-- 426
            |:|||||:.|.:|::|:|..|:..:.....|..|:..||....|         ||..|.||.|
Zfish   367 MMIDGVFRGNPDQVKEYQELLQAVIFQSFEGHAVIPKYYHVPADFVEAEQKKHGSQKRFPSNSGR 431

  Fly   427 ---LFLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQAKPGTGTATDLVVQ 488
               ||||||:.:.||:||..||:...::|||.||:|..::...:.|||    ..|. ...|:|:.
Zfish   432 DGMLFLWGQALYNIAKLLVDGLISPKDIDPIHRYVPRQDQRNVSMRYS----NQGP-IENDVVIH 491

  Fly   489 IVLIAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLG 553
            :.|||||.|||..:.|||||||||.:|||:|||...||:|.|:.|.||.|:||||||.||||.:|
Zfish   492 VALIAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQKELVKAYRFLAVNKKLGLSGRPERPVGCIG 556

  Fly   554 TSKVYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLIREEHM 618
            |.|:|||.|.||:|||::|::|||||.:|:.|||||||..|||:.:.|::.|||...:||||:::
Zfish   557 TCKIYRILGKTVVCYPIVFDLSDFYLSQDVMLLIDDIKNALQFIKQCWKMPGRPLFLVLIREDNI 621

  Fly   619 RDPQFKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEHLDFM--NQSDLTDNENAFSQI--- 678
            :..:|..:||:||..|||...|:||.:.|||.|||.:.:|.|||:  |::::.:.: :|.::
Zfish   622 KGSRFNPILDMLASFKKGNIGGVKVHVDRLQTLISGAVVEQLDFLRVNEAEIPEFK-SFEELELP 685

  Fly   679 NHEYIGYQSLTDVPKALTYVEE-KISVAHFDTKPTPDIINALRSTDSIYCLCQLWGIILNREGPH 742
            .|..:..|  |..|.|....:: :|:...:..|.|.:|:......|.:....||..|:|.:|||.
Zfish   686 KHSKVKRQ--TSTPNASDLEQQPEINDEEWFNKSTFEILQKFNDCDCLASQAQLASILLKKEGPE 748

  Fly   743 FEVNGLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHHIVDSISPFITTVLVNGKELTVGIIGQKE 807
            |.....|:...|.::|.||||.:.|..||..:|||..:|||::|.||:|||:||::|:|:.|.:|
Zfish   749 FFNTNENLKDELERIYRRAGSRKLWSVVRLAASLLTKLVDSLAPSITSVLVHGKQVTLGLFGHEE 813

  Fly   808 TVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVLYCGRLIATNPSMFRGILKIRIGWVLEAMR 872
            .|...|::|..|::::|:...|:...:||||||:|::.|.:|:.||.:|.|:||||:||:::||:
Zfish   814 IVISNPLSPGVIKDIIYSKCSPHGEREAVLQQELVIHIGWIISNNPELFSGMLKIRVGWIVQAMK 878

  Fly   873 IYLQI--SGQQSIDVDNLSPFQVRILLQKVLTVSE----WAVEEKLTTLQRRQLEGCLCRVPKHF 931
            ..|:|  ......|:..:||..|:.||..||...:    |        |.|||::|.|.|.|..|
Zfish   879 HELKIRAGDMPPQDIYQMSPSDVKQLLLDVLQSQQSGRSW--------LNRRQIDGSLNRTPLGF 935

  Fly   932 YNKIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCIV 996
            |:::|:||:||..||:..|.|||..|||::|:..|:.|:||||:||..|..||.|||.||||.:|
Zfish   936 YDRVWQILERTRNGIMVGGKHLPQQPTLSDMTMYEMNFSLLVEDTLKNIVLPEYRQIIVELLMVV 1000

  Fly   997 ATILNRNPELHFKQALDLDGILAEAFAMYCKDNNIQHQPKPEHEQTKNEDLKAFYSLP---YSET 1058
            :.:|.|||||.|::.:|||.::.||||.:.||.:     |.|..: |.:.::|||:.|   ...|
Zfish  1001 SIVLERNPELEFQEPVDLDKLVKEAFADFQKDRS-----KLEGTE-KRDTMEAFYNTPALGKQST 1059

  Fly  1059 TGYLARAAVNKVLQGGIFSTNEEDVQLDGDRLHDDNCKVS 1098
            :.||.:|.:.::|||.:..:.            ||.|.||
Zfish  1060 SSYLTKAVMIQLLQGEVKPSK------------DDPCSVS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8475	NP_001260230.1	Glyco_hydro_15	49..>468	CDD:279112	229/433 (53%)
CG8475	NP_001260230.1	Glyco_hydro_15	<739..866	CDD:279112	55/126 (44%)
phkb	XP_005166459.1	Glyco_hydro_15	44..>465	CDD:279112	226/420 (54%)
phkb	XP_005166459.1	Glyco_hydro_15	<745..872	CDD:279112	55/126 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596605
Domainoid	1	1.000	799	1.000	Domainoid score	I73
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H247
Inparanoid	1	1.050	944	1.000	Inparanoid score	I330
OMA	1	1.010	-	-		QHG45596
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0006534
OrthoInspector	1	1.000	-	-		oto40695
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	1	1.100	-	-	LDO	PTHR10749
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3394
SonicParanoid	1	1.000	-	-		X4767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800