DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8475 and phka2

DIOPT Version :9

Sequence 1:	NP_001260230.1	Gene:	CG8475 / 34114	FlyBaseID:	FBgn0031995	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_021335546.1	Gene:	phka2 / 556199	ZFINID:	ZDB-GENE-130422-1	Length:	1224	Species:	Danio rerio

Alignment Length:	1231	Identity:	378/1231 - (30%)
Similarity:	598/1231 - (48%)	Gaps:	238/1231 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QLDIYYGIVKRQLLRYQSPITGLFPVMSTDQVVGSVRDSVYCASAVWSLYQAYRR---IDDDRGK 111
            :||.:..:|...:|.:|:|:|||.|. |..|....|||:||...|||.|..|||:   .|:|:.|
Zfish    10 RLDGFARLVHETILCHQNPVTGLLPA-SEQQKDAWVRDNVYSILAVWGLGMAYRKNADRDEDKAK 73

  Fly   112 SYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCV 176
            :|||.||.||.|:|:|:|.::|..:||.||..||.:..||:|:...|...:..|:.:.|||:|..
Zfish    74 AYELEQSVVKLMQGLLQCMMRQVEKVEKFKHTQSTKDCLHAKYHTPTCATVVGDDQWGHLQVDAT 138

  Fly   177 SLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIG 241
            |||||.|.||..|||.||...|||||:||||:|:|.||:..|:||||||.|.|.|.||::.||:|
Zfish   139 SLYLLTLAQMTASGLHIISNLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIPELNGSSVG 203

  Fly   242 MAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAF 306
            |||:|||||:..:|||..|...||::|..|.....:||..:||||.|:||.:||.||..:|||||
Zfish   204 MAKAALEAIDELDLFGAHGGPKSVIHVLPDEVEHCQSILCSMLPRASTSKEIDAGLLSVISFPAF 268

  Fly   307 ASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFI 371
            |..:..||..||..::.:|:.:.|..||.|||:.:..||.:|.:|...|||.||.:|||||:|:.
Zfish   269 AVEDADLVNITKAEIITKLQGRYGCCRFIRDGYRTPKEDPTRLHYDPAELKLFENIECEWPVFWT 333

  Fly   372 AMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYAPDGD--GSYMRAP--------SQS 426
            .:|:||:|..::||:||::..|...|....:|..:|...||...|  ....|.|        .|.
Zfish   334 YLILDGIFNADHEQVEEYREALDGVLIRGKHGIRLVPELYAVPADKVEEEYRNPHSVERVAFGQL 398

  Fly   427 LFLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQAKPGTGTATDLVVQIVL 491
            ..:||||.:|:..|||.|.|...|:||:.|            |:|. :.||      |:|||:.:
Zfish   399 PHMWGQSLYILGSLLTEGFLAPGEIDPLNR------------RFSK-EFKP------DVVVQVSV 444

  Fly   492 IAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLGTSK 556
            :|||:::|.::..:||:.||..:|.|:::..:..|..:|..||...|:.|||||.|.:|.|||||
Zfish   445 VAESVQIQQLLRDHGIEVQTVSDVSPIRVMPARILSHIYVKLGNCKKLNLSGRPYRHIGVLGTSK 509

  Fly   557 VYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTV------CLLIRE 615
            .|.|...|....|...:...|||..|..::::.::|||.::...||::||||:      .:|:.:
Zfish   510 FYEIRNGTYTFTPQFIDQHHFYLALDNQMIVEMLRTELAYLSSCWRMTGRPTLTFPITQSMLVED 574

  Fly   616 EHMRDPQFKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEHLDFM---NQSDLTDNE----- 672
            ....||.   :|..|..|:.||..|.:|::..|.:.:::|....|.|:   ::.||.:.|
Zfish   575 GDSIDPC---ILSTLRKLQDGYFGGARVQMANLSSFLTTSFHTQLSFLDGDSEEDLLEEEEEEDE 636

  Fly   673 --------NAFSQI---------------------NHEYIGYQSLTDV------------PKALT 696
                    :.|.|.                     :|.:....:..|:            ||...
Zfish   637 EASAGGSGDMFDQYLTDLLHSTTTKCHLPPIQRGQHHVFSAEHTTRDILSFMAQVQGHNMPKPSM 701

  Fly   697 YV-------EEKISVAHFDT---KPTPD----------------------IINALRSTDSIYCLC 729
            |:       :.:.|:...|.   |.:|.                      :::.|:...::....
Zfish   702 YLPVAPIMSKHRKSLNLLDVPQHKASPQTKADNVDLHLPRDSHGNTDFVHLVDQLKHCPTLQDQA 766

  Fly   730 QLWGIILNREGPHFEVN-----GLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHHIVDSISPFIT 789
            .:..::...:||::.|:     ...|.:.|.:||.|||:.:.|..:||.|.:|...|:.::...|
Zfish   767 DILYVLYAMKGPNWVVSLSGQGEATVRSLLEELYVRAGACKEWGLIRYISGILKKRVEVLAEACT 831

  Fly   790 TVLVNGKELTVGIIGQ-KETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVLYCGRLIATNP 853
            .::.:.|:||||:..: :|.|...|:.|.|:.:::| .....|:..|||.||:::|....:.:.|
Zfish   832 DLISHHKQLTVGLPPEPREKVITVPLPPEELISLIY-EASGQDISIAVLTQEIMVYLAMYVRSQP 895

  Fly   854 SMFRGILKIRIGWVLEAMRI----YLQISGQQ-SIDVDNLSPFQVRILLQKVLTVSEWAVE---- 909
            |:|..:|::|||.:::.|..    .|..||:: |..:.:||||.::.||..:|:..|:.||
Zfish   896 SLFGDMLRLRIGLIMQVMATELARSLHCSGEEASESLMSLSPFDMKNLLHHILSGKEFGVERSMR 960

  Fly   910 -----------------------------EKLTT------------------------------- 914
                                         .||.|
Zfish   961 PIQSSATSPAISIHELGHTGATKTERTGIRKLKTEIKQLDDSRPISIYSSSHSISSNVTSPRSTR 1025

  Fly   915 ------------------------------LQRRQLEGCLCRVPKHFYNKIWEILQRTPQGILTQ 949
                                          |:||:|:|.:.|||..||.|:|:|||:. .|:...
Zfish  1026 CSSPSTPSGILSPTGTGDCHLQWEERQGQWLRRRRLDGAINRVPMGFYQKVWKILQKC-HGLSIA 1089

  Fly   950 GHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCIVATILNRN-PELHFKQALD 1013
            |:.||:: |...|:.||:.|.:.||..|..:.:||.||:.||.:.::..:.:.. |.:  ...:.
Zfish  1090 GYVLPSS-TTREMTEGEIKFAVHVESVLNHVPQPEYRQLLVEAIMVLTLVADMEIPSV--GGIIH 1151

  Fly  1014 LDGILAEAFAMYCKDNNIQHQPKPEHEQTKNEDLKAFY--SLPYSE--TTGYLARAAVNKV 1070
            :|.|:..|..::.:|.......:...||.....:..|:  |.|...  |..||::|.|..|
Zfish  1152 IDRIVHMANDLFQQDQRSSGANEYFLEQDPATGICNFFYDSAPSGSYGTMTYLSKAVVTYV 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8475	NP_001260230.1	Glyco_hydro_15	49..>468	CDD:279112	188/430 (44%)
CG8475	NP_001260230.1	Glyco_hydro_15	<739..866	CDD:279112	41/132 (31%)
phka2	XP_021335546.1	Glyco_hydro_15	8..>437	CDD:307049	192/446 (43%)
phka2	XP_021335546.1	Glyco_hydro_15	<790..908	CDD:330284	38/118 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720