DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8475 and PHKB

DIOPT Version :9

Sequence 1:NP_001260230.1 Gene:CG8475 / 34114 FlyBaseID:FBgn0031995 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_000284.1 Gene:PHKB / 5257 HGNCID:8927 Length:1093 Species:Homo sapiens


Alignment Length:1104 Identity:513/1104 - (46%)
Similarity:715/1104 - (64%) Gaps:71/1104 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 HNSLEEINLDQFLKTSNYEDTVKQLDIYYGIVKRQLLRYQSPITGLFPVMST--DQVVGSVRDSV 89
            :..|:.|||.:    .:.|....:||.||.|||..||.||||.|||||..:.  || ...::||:
Human    29 YEPLKSINLPR----PDNETLWDKLDHYYRIVKSTLLLYQSPTTGLFPTKTCGGDQ-KAKIQDSL 88

  Fly    90 YCASAVWSLYQAYRRIDDDRGKSYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKF 154
            |||:..|:|..||||||||:|:::||..|.:|||||||.|:::||.:|:.|||.......|||.|
Human    89 YCAAGAWALALAYRRIDDDKGRTHELEHSAIKCMRGILYCYMRQADKVQQFKQDPRPTTCLHSVF 153

  Fly   155 QLHTGEKIYPDEFYNHLQIDCVSLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDF 219
            .:|||:::...|.|.||||:.||||||:||:||:|||||||..|||:|:||||:.|||.||.|||
Human   154 NVHTGDELLSYEEYGHLQINAVSLYLLYLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDF 218

  Fly   220 GMWERGSKYNNGTPEIHASSIGMAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETML 284
            |:||||||||||:.|:|:||:|:||:|||||||.||||.:|.||||::||:|||||||....::|
Human   219 GVWERGSKYNNGSTELHSSSVGLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLL 283

  Fly   285 PRESSSKGVDASLLLTLSFPAFASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRR 349
            ||||.|...||:||..:|:||||..::.|..||...||.:|:.|.|||||.|||:.:..||.:|.
Human   284 PRESRSHNTDAALLPCISYPAFALDDEVLFSQTLDKVVRKLKGKYGFKRFLRDGYRTSLEDPNRC 348

  Fly   350 YYHSGELKEFEGLECEWPLFFIAMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYAPD 414
            ||...|:|.|:|:|||:|:||:.|:|||||:.|.:|::|:|:.|...|.....|.|||..||...
Human   349 YYKPAEIKLFDGIECEFPIFFLYMMIDGVFRGNPKQVQEYQDLLTPVLHHTTEGYPVVPKYYYVP 413

  Fly   415 GD---------GSYMRAPSQ-----SLFLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPR 465
            .|         ||..|.||.     .||||||:.:|||:||...|:...::||::||:|..::..
Human   414 ADFVEYEKNNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLADELISPKDIDPVQRYVPLKDQRN 478

  Fly   466 RAGRYSAFQAKPGTG-TATDLVVQIVLIAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKV 529
            .:.|:|      ..| ...||||.:.|||||.|||..:.|||||||||.:|||:|||...||:|.
Human   479 VSMRFS------NQGPLENDLVVHVALIAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQQELVKA 537

  Fly   530 YQHLGVNNKVGLSGRPCRPVGSLGTSKVYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTEL 594
            |..||:|.|:||||||.||:|.|||||:|||.|.||:|||:||::||||:.:|:.|||||||..|
Human   538 YLQLGINEKLGLSGRPDRPIGCLGTSKIYRILGKTVVCYPIIFDLSDFYMSQDVFLLIDDIKNAL 602

  Fly   595 QFVGKYWRLSGRPTVCLLIREEHMRDPQFKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEH 659
            ||:.:||::.|||...:||||:::|..:|..:||:||.||||...|:||.:.|||.|||.:.:|.
Human   603 QFIKQYWKMHGRPLFLVLIREDNIRGSRFNPILDMLAALKKGIIGGVKVHVDRLQTLISGAVVEQ 667

  Fly   660 LDFMNQSDLTD--NENAFSQI---NHEYIGYQSLTDVPKALTYVEE-KISVAHFDTKPTPDIINA 718
            |||:..||..:  ...:|.::   .|..:..||.|  |.|....:: .::::.:..|||.:|:..
Human   668 LDFLRISDTEELPEFKSFEELEPPKHSKVKRQSST--PSAPELGQQPDVNISEWKDKPTHEILQK 730

  Fly   719 LRSTDSIYCLCQLWGIILNREGPHFEVNGLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHHIVDS 783
            |.....:.....|.||:|.||||:|......|:..:.::|.||||.:.|.||||.::.......|
Human   731 LNDCSCLASQAILLGILLKREGPNFITKEGTVSDHIERVYRRAGSQKLWLAVRYGAAFTQKFSSS 795

  Fly   784 ISPFITTVLVNGKELTVGIIGQKETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVLYCGRL 848
            |:|.|||.||:||::|:|..|.:|.|...|::|..|||::|.....:|..:||:|||:|::.|.:
Human   796 IAPHITTFLVHGKQVTLGAFGHEEEVISNPLSPRVIQNIIYYKCNTHDEREAVIQQELVIHIGWI 860

  Fly   849 IATNPSMFRGILKIRIGWVLEAMRIYLQISG--QQSIDVDNLSPFQVRILLQKVLTVSE----WA 907
            |:.||.:|.|:|||||||::.||...|||.|  :.::|:..|||.:|:.||..:|...:    | 
Human   861 ISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPALDLYQLSPSEVKQLLLDILQPQQNGRCW- 924

  Fly   908 VEEKLTTLQRRQLEGCLCRVPKHFYNKIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNLL 972
                   |.|||::|.|.|.|..||:::|:||:|||.||:..|.|||..|||::|:..|:.|:||
Human   925 -------LNRRQIDGSLNRTPTGFYDRVWQILERTPNGIIVAGKHLPQQPTLSDMTMYEMNFSLL 982

  Fly   973 VEETLICIDRPERRQITVELLCIVATILNRNPELHFKQALDLDGILAEAFAMYCKDNNIQHQPKP 1037
            ||:||..||:|:.|||.||||.:|:.:|.|||||.|:..:|||.::.|||..:.||   |.:.| 
Human   983 VEDTLGNIDQPQYRQIVVELLMVVSIVLERNPELEFQDKVDLDRLVKEAFNEFQKD---QSRLK- 1043

  Fly  1038 EHEQTKNEDLKAFYSLP---YSETTGYLARAAVNKVLQGGIFSTNEEDVQLDGDRLHDDNCKVS 1098
              |..|.:|:.:||:.|   ...|..||.:|.:|.:|:|.:...|            ||.|.:|
Human  1044 --EIEKQDDMTSFYNTPPLGKRGTCSYLTKAVMNLLLEGEVKPNN------------DDPCLIS 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8475NP_001260230.1 Glyco_hydro_15 49..>468 CDD:279112 228/434 (53%)
Glyco_hydro_15 <739..866 CDD:279112 54/126 (43%)
PHKBNP_000284.1 Calmodulin-binding. /evidence=ECO:0000255 7..29 513/1104 (46%)
Glyco_hydro_15 49..>470 CDD:279112 225/421 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 689..716 6/28 (21%)
Glyco_hydro_15 <751..878 CDD:279112 54/126 (43%)
Calmodulin-binding. /evidence=ECO:0000255 768..795 10/26 (38%)
Calmodulin-binding. /evidence=ECO:0000255 920..951 14/38 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160268
Domainoid 1 1.000 802 1.000 Domainoid score I73
eggNOG 1 0.900 - - E1_KOG3635
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H247
Inparanoid 1 1.050 956 1.000 Inparanoid score I336
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45596
OrthoDB 1 1.010 - - D38956at33208
OrthoFinder 1 1.000 - - FOG0006534
OrthoInspector 1 1.000 - - oto89092
orthoMCL 1 0.900 - - OOG6_101837
Panther 1 1.100 - - LDO PTHR10749
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3394
SonicParanoid 1 1.000 - - X4767
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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