Protein Alignment CG8475 and PHKA2

DIOPT Version :9

• Sequence 1: NP_001260230.1
• Gene: CG8475 / 34114
• FlyBaseID: FBgn0031995
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_006724559.1
• Gene: PHKA2 / 5256
• HGNCID: 8926
• Length: 1243
• Species: Homo sapiens
• Alignment Length: 1247
• Identity: 380/1247 - (30%)
• Similarity: 596/1247 - (47%)
• Gaps: 255/1247 - (20%)

  Fly    50 QLDIYYGIVKRQLLRYQSPITGLFPVMSTDQVVGSVRDSVYCASAVWSLYQAYRR---IDDDRGK 111
            :||.|..:|::.:|.||:|:|||... |.:|....|||::|...|||.|..|||:   .|:|:.|
Human    10 RLDGYARLVQQTILCYQNPVTGLLSA-SHEQKDAWVRDNIYSILAVWGLGMAYRKNADRDEDKAK 73

  Fly   112 SYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCV 176
            :|||.|:.||.|||:|:|.::|.::||.||..||.:.:||:|:...|...:..|:.:.|||:|..
Human    74 AYELEQNVVKLMRGLLQCMMRQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVGDDQWGHLQVDAT 138

  Fly   177 SLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIG 241
            ||:||||.||..|||:||:|.|||||:||||:|:|.||:..|:||||||.|.|.|.||::|||:|
Human   139 SLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIPELNASSVG 203

  Fly   242 MAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAF 306
            |||:|||||:..:|||..|...||::|..|.....:||..:||||.|:||.:||.||..:|||||
Human   204 MAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLLSIISFPAF 268

  Fly   307 ASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFI 371
            |..:..||..||..::::|:.:.|..||.|||:.:..||.:|.:|...|||.||.:|||||:|:.
Human   269 AVEDVNLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPNRLHYDPAELKLFENIECEWPVFWT 333

  Fly   372 AMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYA--PDG-DGSYM------RAPSQSL 427
            ..||||||..:..|::|::..|...|....||..:|...||  |:. |..|.      |.|...:
Human   334 YFIIDGVFSGDAVQVQEYREALEGILIRGKNGIRLVPELYAVPPNKVDEEYKNPHTVDRVPMGKV 398

  Fly   428 -FLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQAKPGTGTATDLVVQIVL 491
             .|||||.:|::.||..|.|...|:||:.|            |:|       |....|:|||:.:
Human   399 PHLWGQSLYILSSLLAEGFLAAGEIDPLNR------------RFS-------TSVKPDVVVQVTV 444

  Fly   492 IAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLGTSK 556
            :||:..::.::..:|:..|:..::.|:|:.....|..:|..||.|..:.|||||.|.:|.|||||
Human   445 LAENNHIKDLLRKHGVNVQSIADIHPIQVQPGRILSHIYAKLGRNKNMNLSGRPYRHIGVLGTSK 509

  Fly   557 VYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLIREEHMRDP 621
            :|.|........|...:...|||..|..::::.::.||.::...||::||||:...|....:.:.
Human   510 LYVIRNQIFTFTPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWRMTGRPTLTFPISRTMLTND 574

  Fly   622 Q---FKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEHLDFM-------------------- 663
            .   ...:|..:..|:.||..|.:|::|.|...:::|...:|.|:
Human   575 GSDIHSAVLSTIRKLEDGYFGGARVKLGNLSEFLTTSFYTYLTFLDPDCDEKLFDNASEGTFSPD 639

  Fly   664 NQSDL------TDNENAFSQINHEYIGY--QSLT------------------------------- 689
            :.|||      |.|:.:..:::| ||.:  ||.:
Human   640 SDSDLVGYLEDTCNQESQDELDH-YINHLLQSTSLRSYLPPLCKNTEDRHVFSAIHSTRDILSVM 703

  Fly   690 ------DVP---------------KALTYVE------EKISVAHFDTKPTPD--------IINAL 719
                  :||               |:|..|:      ||:..:.|.. |..|        ::..|
Human   704 AKAKGLEVPFVPMTLPTKVLSAHRKSLNLVDSPQPLLEKVPESDFQW-PRDDHGDVDCEKLVEQL 767

  Fly   720 RSTDSIYCLCQLWGIILNREGPHFEVN-----GLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHH 779
            :...::.....:..|:...:||.::.|     |:.|...|.:||.:||..:.|..:||.|.||..
Human   768 KDCSNLQDQADILYILYVIKGPSWDTNLSGQHGVTVQNLLGELYGKAGLNQEWGLIRYISGLLRK 832

  Fly   780 IVDSISPFITTVLVNGKELTVGIIGQ-KETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVL 843
            .|:.::...|.:|.:.|:||||:..: :|.:...|:.|.|:..::| .....|:..|||.||:|:
Human   833 KVEVLAEACTDLLSHQKQLTVGLPPEPREKIISAPLPPEELTKLIY-EASGQDISIAVLTQEIVV 896

  Fly   844 YCGRLIATNPSMFRGILKIRIGWVLEAMRI----YLQISGQQ-SIDVDNLSPFQVRILLQKVLTV 903
            |....:...||:|..:|::|||.:::.|..    .|..||:: |..:.|||||.::.||..:|:.
Human   897 YLAMYVRAQPSLFVEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKNLLHHILSG 961

  Fly   904 SEWAVEEKLTT------------------------------------------------------ 914
            .|:.||..:..
Human   962 KEFGVERSVRPIHSSTSSPTISIHEVGHTGVTKTERSGINRLRSEMKQMTRRFSADEQFFSVGQA 1026

  Fly   915 -------------------------------------------------LQRRQLEGCLCRVPKH 930
                                                             |:||:|:|.:.|||..
Human  1027 ASSSAHSSKSAVTVPRDYCRSSTPSSPTGTSSSDSGGHHIGWGERQGQWLRRRRLDGAINRVPVG 1091

  Fly   931 FYNKIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCI 995
            ||.::|:|||:. .|:...|:.||:: |...|:..|:.|.:.||..|..:.:||.||:.||.: :
Human  1092 FYQRVWKILQKC-HGLSIDGYVLPSS-TTREMTPHEIKFAVHVESVLNRVPQPEYRQLLVEAI-M 1153

  Fly   996 VATILNRNPELHFKQALDLDGILAEAFAMYCKDN-NIQHQPKPEHEQTKNEDLKAFYSLPYSETT 1059
            |.|:|:..........:.:|.|:..|..::.:|. :|......|.:|... ....||....|...
Human  1154 VLTLLSDTEMTSIGGIIHVDQIVQMASQLFLQDQVSIGAMDTLEKDQATG-ICHFFYDSAPSGAY 1217

  Fly  1060 G---YLARAAVN 1068
            |   ||.||..:
Human  1218 GTMTYLTRAVAS 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8475	NP_001260230.1	Glyco_hydro_15	49..>468	CDD:279112	192/430 (45%)
		Glyco_hydro_15	<739..866	CDD:279112	43/132 (33%)
PHKA2	XP_006724559.1	Glyco_hydro_15	8..>439	CDD:279112	196/448 (44%)
		Glyco_hydro_15	<802..919	CDD:279112	39/117 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720