Protein Alignment CG8475 and PHKA1

DIOPT Version :10

• Sequence 1: NP_001260230.1
• Gene: CG8475 / 34114
• FlyBaseID: FBgn0031995
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001417997.1
• Gene: PHKA1 / 5255
• HGNCID: 8925
• Length: 1240
• Species: Homo sapiens
• Alignment Length: 1252
• Identity: 380/1252 - (30%)
• Similarity: 597/1252 - (47%)
• Gaps: 264/1252 - (21%)

  Fly    50 QLDIYYGIVKRQLLRYQSPITGLFPVMSTDQVVGSVRDSVYCASAVWSLYQAYRR---IDDDRGK 111
            :||.|..:|::.:|.:|:|:|||.|. |.||....|||:||...|||.|..|||:   .|:|:.|
Human    10 RLDGYARLVQQTILCHQNPVTGLLPA-SYDQKDAWVRDNVYSILAVWGLGLAYRKNADRDEDKAK 73

  Fly   112 SYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCV 176
            :|||.||.||.|||:|.|.::|..:||.||..||.:.:||:|:...|...:..|:.:.|||:|..
Human    74 AYELEQSVVKLMRGLLHCMIRQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDAT 138

  Fly   177 SLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIG 241
            |:|||||.||..|||.||::.|||.|:||||:|:|.||:|.|||:||||.|.|.|..|::|||:|
Human   139 SVYLLFLAQMTASGLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASSVG 203

  Fly   242 MAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAF 306
            |||:||||::..:|||.||...||::|..|.....:||..::|||.|:||.||||||..:|||||
Human   204 MAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNSLLPRASTSKEVDASLLSVVSFPAF 268

  Fly   307 ASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFI 371
            |..:.:|||.|||.::.:|:.:.|..||.|||:.:..||.:|.||...|||.||.:|||||||:.
Human   269 AVEDSQLVELTKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFENIECEWPLFWT 333

  Fly   372 AMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYA--PDG-DGSYM------RAPSQSL 427
            ..|:||||..|.||::|::..|...|....||.|::...|:  ||. |..|.      |.|...|
Human   334 YFILDGVFSGNAEQVQEYKEALEAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKL 398

  Fly   428 -FLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQAKPGTGTATDLVVQIVL 491
             .:||||.:|:..|:..|.|...|:||:.|...:..:|                   |:|||:.:
Human   399 PHMWGQSLYILGSLMAEGFLAPGEIDPLNRRFSTVPKP-------------------DVVVQVSI 444

  Fly   492 IAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLGTSK 556
            :||:..::.::...||..:|..||.|:::..:..|..:|..||.||::.|||||.|.:|.|||||
Human   445 LAETEEIKTILKDKGIYVETIAEVYPIRVQPARILSHIYSSLGCNNRMKLSGRPYRHMGVLGTSK 509

  Fly   557 VYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLIREEHMRDP 621
            :|.|........|...:...|||..|..::::.::|:|.::...||::|:||:...|....:.:.
Human   510 LYDIRKTIFTFTPQFIDQQQFYLALDNKMIVEMLRTDLSYLCSRWRMTGQPTITFPISHSMLDED 574

  Fly   622 QFKEMLDLLAMLKK---GYCDGMKVRIGRLQNLISSSCIEHLDFMN--------QSDLTDN---- 671
            .......:||.|:|   ||..|.:|:.|:|...:::||..||.||:        ..|..||
Human   575 GTSLNSSILAALRKMQDGYFGGARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNYDYL 639

  Fly   672 -----ENAFSQINHEYIG-----------------------------------YQSLTDVPKALT 696
                 .|.:...:|...|                                   .|:..|:...:|
Human   640 ESGNWMNDYDSTSHARCGDEVARYLDHLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMSLVT 704

  Fly   697 ------------YVEEKISVAHFDTKPTPDIINA------------------------------- 718
                        |:..|:..|   ::|:.:::::
Human   705 KAKELHVQNVHMYLPTKLFQA---SRPSFNLLDSPHPRQENQVPSVRVEIHLPRDQSGEVDFKAL 766

  Fly   719 ---LRSTDSIYCLCQLWGIILNREGPHFEVNGLNVNTA-----LTQLYHRAGSLRYWRAVRYCSS 775
               |:.|.|:.....:..::...:||.:.....|..:|     ||:||.:.|.:|:|..:||.|.
Human   767 VLQLKETSSLQEQADILYMLYTMKGPDWNTELYNERSATVRELLTELYGKVGEIRHWGLIRYISG 831

  Fly   776 LLHHIVDSISPFITTVLVNGKELTVGIIGQ-KETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQ 839
            :|...|:::....|.:|.:.|.||||:..: :|.....|: |.|....:.......|:..::|.|
Human   832 ILRKKVEALDEACTDLLSHQKHLTVGLPPEPREKTISAPL-PYEALTQLIDEASEGDMSISILTQ 895

  Fly   840 EVVLYCGRLIATNPSMFRGILKIRIGWVLEAMRI----YLQISGQQSID-VDNLSPFQVRILLQK 899
            |:::|....:.|.|.:|..:.::|||.:::.|..    .|:.|.:::.: :.||||..::.||..
Human   896 EIMVYLAMYMRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHH 960

  Fly   900 VLTVSEWAVEEKL---------------------------------------------------- 912
            :|:..|:.||..:
Human   961 ILSGKEFGVERSVRPTDSNVSPAISIHEIGAVGATKTERTGIMQLKSEIKQVEFRRLSISAESQS 1025

  Fly   913 -------------------TTL-------------------------QRRQLEGCLCRVPKHFYN 933
                               |::                         :||:|:|.|.|||..||.
Human  1026 NGGHPLGIDLMSPSFMSPGTSMTPSSGSFPSAYDQQSSKDSRQGQWQRRRRLDGALNRVPVGFYQ 1090

  Fly   934 KIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCIVAT 998
            |:|::||:. .|:..:|..||:: |...|:.||:.|::.||..|..:.:||.||:.||.: :|.|
Human  1091 KVWKVLQKC-HGLSVEGFVLPSS-TTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAI-LVLT 1152

  Fly   999 ILNRNPELHFKQALDLDGILA-EAFAMYCKDNNIQHQPKPEHEQT--KNEDLKAFYSLPYSE--- 1057
            :| .:.|:|     .:..|:| |.......|..:|.|.....:.|  ..:......:|.|..
Human  1153 ML-ADIEIH-----SIGSIIAVEKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTLLYDSAPS 1211

  Fly  1058 ----TTGYLARAAVNKV 1070
                |..||::||...|
Human  1212 GRFGTMTYLSKAAATYV 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8475	NP_001260230.1	Glyco_hydro_15	49..>468	CDD:395586	199/430 (46%)
		Bac_rhamnosid6H	<739..866	CDD:481215	37/132 (28%)
		KPBB_C	887..1065	CDD:437124	60/283 (21%)
PHKA1	NP_001417997.1	Glyco_hydro_15	8..>439	CDD:395586	200/448 (45%)
		Bac_rhamnosid6H	<804..922	CDD:481215	34/118 (29%)
		Calmodulin-binding. /evidence=ECO:0000255	810..840		12/29 (41%)
		Calmodulin-binding. /evidence=ECO:0000255	1063..1103		15/40 (38%)
		KPBB_C	<1077..>1151	CDD:437124	30/76 (39%)