DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8475 and Phkb

DIOPT Version :9

Sequence 1:	NP_001260230.1	Gene:	CG8475 / 34114	FlyBaseID:	FBgn0031995	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001014174.1	Gene:	Phkb / 361377	RGDID:	620186	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	1096	Identity:	502/1096 - (45%)
Similarity:	702/1096 - (64%)	Gaps:	75/1096 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HNSLEEINLDQFLKTSNYEDTVKQLDIYYGIVKRQLLRYQSPITGLFPVMST--DQVVGSVRDSV 89
            :..|:.|||.:    .:.|....:||.||.|||..:|.||||.|||||..:.  || ...|.:|:
  Rat    29 YEPLKSINLPR----PDNETLWDKLDHYYRIVKSTMLTYQSPTTGLFPTKTCGGDQ-KSKVHESL 88

  Fly    90 YCASAVWSLYQAYRRIDDDRGKSYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKF 154
            |||:..|:|..||||||||:|:::||..|.:|||||:|.|:::||.:|:.|||.......|||.|
  Rat    89 YCAAGAWALALAYRRIDDDKGRTHELEHSAIKCMRGVLYCYMRQADKVQQFKQDPRPTTCLHSVF 153

  Fly   155 QLHTGEKIYPDEFYNHLQIDCVSLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDF 219
            .:|||:::...|.|.||||:.|||:||:||:||:|||||||..|||:|:||||:.|||.||.|||
  Rat   154 NVHTGDEVLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDF 218

  Fly   220 GMWERGSKYNNGTPEIHASSIGMAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETML 284
            |:||||||||||:.|:|:||:|:||:|||||||.||||.:|.||||::||:|||||||....::|
  Rat   219 GVWERGSKYNNGSTELHSSSVGLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLL 283

  Fly   285 PRESSSKGVDASLLLTLSFPAFASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRR 349
            ||||.|...||:||..:::||||..::.|..||...|:.:|:.|.|||||.|||:.:..||.:||
  Rat   284 PRESRSHNTDAALLPCITYPAFALDDEALFSQTLDKVIRKLKGKYGFKRFLRDGYRTPLEDPNRR 348

  Fly   350 YYHSGELKEFEGLECEWPLFFIAMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYAPD 414
            ||...|:|.|:|:|||:|:||:.::|||||:.|.||::|:|:.|...|.....|.|||..||...
  Rat   349 YYKPAEIKLFDGIECEFPIFFLYLMIDGVFRGNLEQVKEYQDLLTPLLHQTTEGYPVVPKYYYVP 413

  Fly   415 GD---------GSYMRAPSQ-----SLFLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPR 465
            .|         ||..|.||.     .||||||:.:|||:||...|:...::||:.|::|..|:..
  Rat   414 ADFVEYEKRNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLADELISPKDIDPVHRFVPLQNQRN 478

  Fly   466 RAGRYSAFQAKPGTG-TATDLVVQIVLIAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKV 529
            .:.|:|      ..| ...||||.:.|:|||.|||..:.|||||||||.:|||:|||...||:|.
  Rat   479 VSMRFS------NQGPLENDLVVHVALVAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQQELVKA 537

  Fly   530 YQHLGVNNKVGLSGRPCRPVGSLGTSKVYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTEL 594
            |.|||:|.|:||||||.||:|.|||||:|||.|.||:|||:||::||||:.:|:.|||||||..|
  Rat   538 YFHLGINEKLGLSGRPDRPIGCLGTSKIYRILGRTVVCYPIIFDLSDFYMSQDVLLLIDDIKNAL 602

  Fly   595 QFVGKYWRLSGRPTVCLLIREEHMRDPQFKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEH 659
            ||:.:||::.|||...:||||:::|..:|..:||:||..|||...|:||.:.|||.|||.:.:|.
  Rat   603 QFIKQYWKMHGRPLFLVLIREDNIRGSRFNPILDMLAAFKKGIIGGVKVHVDRLQTLISGAVVEQ 667

  Fly   660 LDFMNQSDLTDNENAFSQI------NHEYIGYQSLT-DVPKALTYVEEKISVAHFDTKPTPDIIN 717
            |||:..|| |:....|...      .|..:..||.| |.|:...  |..|::..:..|.|.:|:.
  Rat   668 LDFLRISD-TEKLPEFKSFEELEFPKHSKVKRQSSTADAPELRQ--EPDITITEWKNKSTHEILQ 729

  Fly   718 ALRSTDSIYCLCQLWGIILNREGPHFEVNGLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHHIVD 782
            .|.....:.....|.||:|.||||:|......|:..:.::|.||||.:.|..||..:|||:.:||
  Rat   730 KLNDCGCLAGQTILLGILLKREGPNFITMEGTVSDHIERVYRRAGSKKLWSVVRRAASLLNKVVD 794

  Fly   783 SISPFITTVLVNGKELTVGIIGQKETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVLYCGR 847
            |::|.||.|||.||::|:|..|.:|.|...|::|..|:|::|.....:|..:||:|||:|::.|.
  Rat   795 SLAPSITNVLVQGKQVTLGAFGHEEEVISNPLSPRVIKNIIYYKCNTHDEREAVIQQELVIHIGW 859

  Fly   848 LIATNPSMFRGILKIRIGWVLEAMRIYLQISG--QQSIDVDNLSPFQVRILLQKVLTVSE----W 906
            :|:.||.:|.|:|||||||::.||...|||.|  :.::|:..|||.:|:.||..:|...:    |
  Rat   860 IISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPAVDLYQLSPSEVKQLLLDILQPQQSGRCW 924

  Fly   907 AVEEKLTTLQRRQLEGCLCRVPKHFYNKIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNL 971
                    |.|||::|.|.|.|..||:::|:||:|||.||:..|.|||..|||::|:..|:.|:|
  Rat   925 --------LNRRQIDGSLNRTPPGFYDRVWQILERTPNGIVVAGKHLPQQPTLSDMTMYEMNFSL 981

  Fly   972 LVEETLICIDRPERRQITVELLCIVATILNRNPELHFKQALDLDGILAEAFAMYCKDNN----IQ 1032
            |||:.|..||:|:.|||.||||.:|:.:|.|||||.|:..:|||.::.|||..:.||.:    |:
  Rat   982 LVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEFQDKVDLDKLVKEAFHEFQKDESRLKEIE 1046

  Fly  1033 HQPKPEHEQTKN----EDLKAFYSLPYSETTGYLARAAVNKVLQGGIFSTNEEDVQ 1084
            .|...|....:|    ..::...:||..:|.|.               ||.|:.:|
  Rat  1047 KQVSGEARVPQNAFIVSTVEILSNLPTFQTDGQ---------------STKEDALQ 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8475	NP_001260230.1	Glyco_hydro_15	49..>468	CDD:279112	224/434 (52%)
CG8475	NP_001260230.1	Glyco_hydro_15	<739..866	CDD:279112	55/126 (44%)
Phkb	NP_001014174.1	Glyco_hydro_15	49..>349	CDD:279112	170/300 (57%)
Phkb	NP_001014174.1	Glyco_hydro_15	<751..878	CDD:279112	55/126 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354318
Domainoid	1	1.000	792	1.000	Domainoid score	I70
eggNOG	1	0.900	-	-		E1_KOG3635
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H247
Inparanoid	1	1.050	933	1.000	Inparanoid score	I332
OMA	1	1.010	-	-		QHG45596
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0006534
OrthoInspector	1	1.000	-	-		oto96222
orthoMCL	1	0.900	-	-		OOG6_101837
Panther	1	1.100	-	-	LDO	PTHR10749
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770