DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8475 and phkb

DIOPT Version :9

Sequence 1:	NP_001260230.1	Gene:	CG8475 / 34114	FlyBaseID:	FBgn0031995	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_002931715.3	Gene:	phkb / 100493974	XenbaseID:	XB-GENE-1010420	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	1127	Identity:	507/1127 - (44%)
Similarity:	708/1127 - (62%)	Gaps:	81/1127 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRDVPKSLGLSVTTPGGSSGAPDSGRHNSLEEINLDQFLKTSNYEDTVKQLDIYYGIVKRQLLRY 65
            :|...:|.| ||..|..||..|... |.||.|                 :||.||.|||..:|.|
Frog    21 LRSGKESYG-SVYEPIKSSDLPRPD-HESLWE-----------------KLDRYYRIVKITVLNY 66

  Fly    66 QSPITGLFPVMST-DQVVGSVRDSVYCASAVWSLYQAYRRIDDDRGKSYELGQSTVKCMRGILEC 129
            |||.|||||..:. |.....:.||:|||::.|:|..||||||||:|:::||..|.:|||||||.|
Frog    67 QSPQTGLFPTKTAGDFKNAKIHDSLYCAASAWALALAYRRIDDDKGRTHELEHSAIKCMRGILYC 131

  Fly   130 WVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCVSLYLLFLVQMITSGLQII 194
            :::||.:||.|||..|.|..|||.|.:..|::|.....|.|:||:.|||:||:||:||:||||||
Frog   132 YMRQADKVEQFKQDPSPQKCLHSIFNIDNGDEILSYNDYGHIQINAVSLFLLYLVEMISSGLQII 196

  Fly   195 YTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIGMAKSALEAINGCNLFGEK 259
            |..|||:|:||||:.||||||.||||:||||||||||:.|:|:||:|:||:|||||:|.||||.:
Frog   197 YNTDEVSFIQNLVFCVERAYRVPDFGIWERGSKYNNGSTELHSSSVGLAKAALEAIDGFNLFGNQ 261

  Fly   260 GASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAFASHEDRLVEQTKQNVVNR 324
            |.||||::||:|||||||....::|||||.|...||:||..:|:||||..:|.|..||...:..:
Frog   262 GCSWSVIFVDLDAHNRNRQTLSSLLPRESRSHNTDAALLTCISYPAFAVDDDALFNQTLDKIERK 326

  Fly   325 LRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFIAMIIDGVFKNNNEQIEEF 389
            |:.|.|||||.|||:.:..||::||||...|:|.|:|:|||:|||||.|||||||:...||::|:
Frog   327 LKGKYGFKRFLRDGYRTALEDENRRYYKPAEIKLFDGIECEFPLFFIYMIIDGVFRGKAEQVKEY 391

  Fly   390 QNDLRRCLRTDVNGDPVVTMYYAPDGD---------GSYMRAPSQ-----SLFLWGQSFFIIAQL 440
            :..|...|...::|.|||..||....|         .|..|.||.     .||||||:.:|||:|
Frog   392 EALLDPVLFYGLDGCPVVPKYYYVPADFVEAEKMNPNSQKRFPSNCGRDGKLFLWGQALYIIAKL 456

  Fly   441 LTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQAKPGTGTATDLVVQIVLIAESMRLQAMMATY 505
            |...|:...::||:.|::...::.....|||    ..|. ...|.::.:.|||||.|||..:.||
Frog   457 LAEELISPKDIDPMNRFVHLRDQRNIRMRYS----NQGP-LENDAMIHVALIAESQRLQVFLNTY 516

  Fly   506 GIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLGTSKVYRICGMTVLCYPL 570
            |||||||.:|||:|||...||:|.|.|||||||:||||||.||:|.|||||:|||.|.||:.||:
Frog   517 GIQTQTPQQVEPIQIWPQQELVKAYLHLGVNNKLGLSGRPDRPIGCLGTSKIYRILGKTVVSYPI 581

  Fly   571 IFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLIREEHMRDPQFKEMLDLLAMLKK 635
            :|::||||:.:|:.||||||:..|||:.:||:::|||...:||||:::|..:|..:||:||..|.
Frog   582 VFDLSDFYMSQDVMLLIDDIQNALQFIRQYWKMNGRPLFLVLIREDNIRGSRFNPILDMLASFKN 646

  Fly   636 GYCDGMKVRIGRLQNLISSSCIEHLDFM--NQSDLTDNENAFSQI---NHEYIGYQSLTDVPKAL 695
            |...|:||.:.|||.|||.:.:|.|||:  |:::......:|.::   .|..:..|:  .:|.|.
Frog   647 GNVAGVKVHVDRLQTLISGAVVEQLDFLRINETEEVPEFKSFEELEVPKHSKVNRQA--SIPIAD 709

  Fly   696 TYVEEKISVAHFDTKPTPDIINALRSTDSIYCLCQLWGIILNREGPHFEVNGLNVNTALTQLYHR 760
            ...:.:|::..:..|||.:::..|.....:.....|..|:|.||||||......|:..:.::|.:
Frog   710 MEHQPEINMGEWKLKPTYEVLEKLNDCTCLASQAILLSILLKREGPHFITKEGTVSDFMARIYRK 774

  Fly   761 AGSLRYWRAVRYCSSLLHHIVDSISPFITTVLVNGKELTVGIIGQKETVFDKPMTPAEIQNVMYT 825
            |||.:.|..||..:|||..||||::|.||.|||.||::|:|:.|.:|.|...|::|..|::::|.
Frog   775 AGSNKLWSVVRLAASLLGKIVDSLAPSITNVLVQGKQVTLGVFGHEEAVISNPLSPGVIKDILYK 839

  Fly   826 SVQPYDVIQAVLQQEVVLYCGRLIATNPSMFRGILKIRIGWVLEAMRIYLQI-SGQQ-SIDVDNL 888
            ...|||..:||||||:|::.|.:|:..|.:|.|:||||:||::.|||..|:| ||.| ..|:..|
Frog   840 KCSPYDEREAVLQQELVIHIGWIISNTPELFSGMLKIRVGWIVHAMRYELKIRSGDQLERDIYQL 904

  Fly   889 SPFQVRILLQKVLTVSE----WAVEEKLTTLQRRQLEGCLCRVPKHFYNKIWEILQRTPQGILTQ 949
            ||.:::.||..:|...:    |        |.||||:|.|.|.|..||:::|:||:|||.||:..
Frog   905 SPGEIKELLLYILQPQQQGRCW--------LHRRQLDGSLNRNPSGFYDRVWQILERTPSGIIVA 961

  Fly   950 GHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCIVATILNRNPELHFKQALDL 1014
            |..||..|||::|:..|:.|:||||:.|..|.:||.|||.||||.:|:.||.||||..|:..:||
Frog   962 GKFLPQQPTLSDMTMYEMNFSLLVEDMLQNIAQPEYRQIVVELLMVVSVILERNPEFEFQDKVDL 1026

  Fly  1015 DGILAEAFAMYCKDNNIQHQPKPEHEQTKNEDLKAFYSLP---YSETTGYLARAAVNKVLQGGIF 1076
            |.::.|||      |:.|..........|.:|:..||:.|   ...|..||.:|.:|.:|:..:.
Frog  1027 DKLVKEAF------NDFQQDQSRLQGAEKQDDMTMFYNTPPLGKRGTCSYLTKAVMNMLLEAEVK 1085

  Fly  1077 STNEEDVQLDGDRLHDDNCKVS 1098
            .:.|            |.|.||
Frog  1086 PSTE------------DPCIVS 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8475	NP_001260230.1	Glyco_hydro_15	49..>468	CDD:279112	224/433 (52%)
CG8475	NP_001260230.1	Glyco_hydro_15	<739..866	CDD:279112	56/126 (44%)
phkb	XP_002931715.3	Glyco_hydro_15	52..>472	CDD:395586	223/419 (53%)
phkb	XP_002931715.3	Glyco_hydro_15	<753..880	CDD:395586	56/126 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	794	1.000	Domainoid score	I79
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H247
Inparanoid	1	1.050	935	1.000	Inparanoid score	I348
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38956at33208
OrthoFinder	1	1.000	-	-		FOG0006534
OrthoInspector	1	1.000	-	-		oto102949
Panther	1	1.100	-	-	LDO	PTHR10749
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4767
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160