DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Piezo and PIEZO1

DIOPT Version :9

Sequence 1:	NP_001303314.1	Gene:	Piezo / 34112	FlyBaseID:	FBgn0264953	Length:	2973	Species:	Drosophila melanogaster
Sequence 2:	NP_001136336.2	Gene:	PIEZO1 / 9780	HGNCID:	28993	Length:	2521	Species:	Homo sapiens

Alignment Length:	3123	Identity:	802/3123 - (25%)
Similarity:	1284/3123 - (41%)	Gaps:	798/3123 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLTLSTLVLLG 73
            ||..:::|..|:.|.|:|..|:|.||||...:.|:.|..||...:|........||.||.|.|:.
Human     9 VLYWLLLPCALLAACLLRFSGLSLVYLLFLLLLPWFPGPTRCGLQGHTGRLLRALLGLSLLFLVA 73

  Fly    74 HITLQI-LAV-----SLTLPIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVL-VFATSLGS 131
            |:.||| |.:     .|..|  :||..|.|.|||| |:.:||:.       :|..: :.|..||
Human    74 HLALQICLHIVPRLDQLLGP--SCSRWETLSRHIG-VTRLDLKD-------IPNAIRLVAPDLG- 127

  Fly   132 YLTVKRVASQPVGAEQLENGEVVDGQAENAQTSSQPSAADANGGDV--------QQATVTTPLQQ 188
               :..|:|..:|        :....|.|.:.|..|...|.:..||        |:|....|.::
Human   128 ---ILVVSSVCLG--------ICGRLARNTRQSPHPRELDDDERDVDASPTAGLQEAATLAPTRR 181

  Fly   189 QQQQLRKRVSMISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQ-- 251
            .:...|.||:     .|:. ||....:..:..|..|.:..||.....|.|:||...|:|| |.
Human   182 SRLAARFRVT-----AHWL-LVAAGRVLAVTLLALAGIAHPSALSSVYLLLFLALCTWWA-CHFP 239

  Fly   252 TLQRGFALLLRCVMVVLVLHSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLI-ESYCSPDIRVFL 315
            ...|||:.|...|......|.:.:..||.|..|:.|....:.||::||:..: .:.||.. ...:
Human   240 ISTRGFSRLCVAVGCFGAGHLICLYCYQMPLAQALLPPAGIWARVLGLKDFVGPTNCSSP-HALV 303

  Fly   316 YNNKLSLDSYLNPFALFFAYFALALTTK-HLIKPRLVRQSTRKA------------RTPQPLESG 367
            .|..|....|.:|..|....:|.|...| ...:|...|:...|.            :.||..||.
Human   304 LNTGLDWPVYASPGVLLLLCYATASLRKLRAYRPSGQRKEAAKGYEARELELAELDQWPQERESD 368

  Fly   368 SSVAPSV--TQRGNDMQLESMEQRS---------EQENTTTSILDQISYGFVSVGGFIYQNSYIF 421
            ..|.|:.  |:..|.:..|...|.|         ..|....|.|.       |:|..|...||:.
Human   369 QHVVPTAPDTEADNCIVHELTGQSSVLRRPVRPKRAEPREASPLH-------SLGHLIMDQSYVC 426

  Fly   422 TNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNE 486
            ..|.||.|||.|||||||||||.|.::|.:.::.:..|..||.|:||...|...:|::.||| ..
Human   427 ALIAMMVWSITYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGMTLCCLRYVWAMDL-RP 490

  Fly   487 ELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADF 551
            ||||::  ..::|:|:|    :|:...||:.|.....:.|.||:..|||.|||..:..:|.
Human   491 ELPTTL--GPVSLRQLG----LEHTRYPCLDLGAMLLYTLTFWLLLRQFVKEKLLKWAESP---- 545

  Fly   552 IAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRI 616
            .|..::||..       .:..:|...|:..|:::|.:..:.||::...:..:.:..| .:..::|
Human   546 AALTEVTVAD-------TEPTRTQTLLQSLGELVKGVYAKYWIYVCAGMFIVVSFAG-RLVVYKI 602

  Fly   617 CYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQ 681
            .||.|||..|.:||.....|.|::..||..::.|.|.:||.:||:||..|..||.:....:....
Human   603 VYMFLFLLCLTLFQVYYSLWRKLLKAFWWLVVAYTMLVLIAVYTFQFQDFPAYWRNLTGFTDEQL 667

  Fly   682 KDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFI-------ASL---------QQQPLAG 730
            .|:||:::...:||..::.|...::..::|:||||:.|:       .||         .:|....
Human   668 GDLGLEQFSVSELFSSILVPGFFLLACILQLHYFHRPFMQLTDMEHVSLPGTRLPRWAHRQDAVS 732

  Fly   731 GS----------AQQKPTETTALEPAPSKRRGSAGSLRKSQGPSAEAAPGATTDFETSVRDLVRI 785
            |:          .||:..|....|.:..:..|.|...:.:|.|...|..|...:      .|:.:
Human   733 GTPLLREEQQEHQQQQQEEEEEEEDSRDEGLGVATPHQATQVPEGAAKWGLVAE------RLLEL 791

  Fly   786 S--FRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATS-- 846
            :  |..:.::.:...:       |.||||:.|.|.:.....::.||.|::::.|   ||.|.:
Human   792 AAGFSDVLSRVQVFLR-------RLLELHVFKLVALYTVWVALKEVSVMNLLLV---VLWAFALP 846

  Fly   847 RKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSD---NRT----------------A 892
            ....:.:.|.|.:....||::.||:||::.::..:::..|::   |.|                .
Human   847 YPRFRPMASCLSTVWTCVIIVCKMLYQLKVVNPQEYSSNCTEPFPNSTNLLPTEISQSLLYRGPV 911

  Fly   893 NNAEWIGLTKADKVTGGLMSL--LRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPN 955
            :.|.|.|:.|      |..:|  ::.::..::::...|::..||...| :...|...|.:.:|.:
Human   912 DPANWFGVRK------GFPNLGYIQNHLQVLLLLVFEAIVYRRQEHYR-RQHQLAPLPAQAVFAS 969

  Fly   956 IIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQC- 1019
            ..|...::||:|.:||.:||.|||||:||..:..|:.|..|.:.:..::..|||.:|..|..|.
Human   970 GTRQQLDQDLLGCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFLVTLHGCWLVAILTRRHRQAI 1034

  Fly  1020 AKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEG---PFGEGIQRWAMLPGALHFNHVPKL 1081
            |::|..:..|.|:.:|.||::.:|:||:.|:.:||...   |....:.:|..||......:...|
Human  1035 ARLWPNYCLFLALFLLYQYLLCLGMPPALCIDYPWRWSRAVPMNSALIKWLYLPDFFRAPNSTNL 1099

  Fly  1082 IFDFIVLVILNRQKSIFCIE-----QRYAS-NDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSY 1140
            |.||::|:..::|..:|..|     ||.|. |.|           .:..|...|  ||..:|. :
Human  1100 ISDFLLLLCASQQWQVFSAERTEEWQRMAGVNTD-----------RLEPLRGEP--NPVPNFI-H 1150

  Fly  1141 IRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRW 1205
            .|:|.|:||..|....:|..|.|||:.|.....:..||||:..|..|..|:....|.....:..|
Human  1151 CRSYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTALLQRDTRARLVLW 1215

  Fly  1206 KWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG 1270
            ..|:.:||..|:.|....:..|:|:.|:....||::.:..:.||.....:...:.:..:..|.|.
Human  1216 DCLILYNVTVIISKNMLSLLACVFVEQMQTGFCWVIQLFSLVCTVKGYYDPKEMMDRDQDCLLPV 1280

  Fly  1271 ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQI-AH 1334
            |      :..::||::||.|::.|.|:|.|||:.|:..|.:|..:|||||..:..:...|.| .|
Human  1281 E------EAGIIWDSVCFFFLLLQRRVFLSHYYLHVRADLQATALLASRGFALYNAANLKSIDFH 1339

  Fly  1335 RHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAMSDVAPLVHNSSFTSCQGS 1399
            |...||. |.::||:||||||.|:|         |..||...|.
Human  1340 RRIEEKS-LAQLKRQMERIRAKQEK---------HRQGRVDRSR--------------------- 1373

  Fly  1400 GYLTPDEHSSATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYVDVQSVS 1464
                |.:    |.|...|.......|.|||
Human  1374 ----PQD----TLGPKDPGLEPGPDSPGGS----------------------------------- 1395

  Fly  1465 EEETTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLAPPELSPPV 1529
                                                                         |||
Human  1396 -------------------------------------------------------------SPP- 1398

  Fly  1530 GMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSIKRSPMKKQMS 1594
                                                 |||
Human  1399 -------------------------------------RRQ------------------------- 1401

  Fly  1595 ADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARDEAALRSAQRPHSWGPVG 1659
                                                                        |
Human  1402 ------------------------------------------------------------W---- 1402

  Fly  1660 TSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEIDFLEEENITESEMKMQRR 1724
                        :.|.|.|.....:|||::||...::             |||.:.|......:.
Human  1403 ------------WRPWLDHATVIHSGDYFLFESDSEE-------------EEEAVPEDPRPSAQS 1442

  Fly  1725 --KTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEKEKIGPDLGLASDHDEDDDTIE 1787
              :..|..|.....|..||....:|::...:.|
Human  1443 AFQLAYQAWVTNAQAVLRRRQQEQEQARQEQAG-------------------------------- 1475

  Fly  1788 CDLGMRTSTLSEPLDFGRRSQTLLEVKSKDAPTGEFPSTSKGISKERDAATASSSASPAPTRDVG 1852
                                         ..|||..|               |....||.
Human  1476 -----------------------------QLPTGGGP---------------SQEVEPAE----- 1491

  Fly  1853 DLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDFDTNPIIRLLEGFLV-TLTIRL 1916
                 .|.....||....:..                      ..|...:.:|...|| .||..|
Human  1492 -----GPEEAAAGRSHVVQRV----------------------LSTAQFLWMLGQALVDELTRWL 1529

  Fly  1917 NRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSSTPRRVVI 1981
            ..|:|::..::.:|..|:..|.:.       |.....:...:...|.:.::|......|
Human  1530 QEFTRHHGTMSDVLRAERYLLTQE-------LLQGGEVHRGVLDQLYTSQAEATLPGPT------ 1581

  Fly  1982 APPNATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRA-AEEIIELPVD 2045
            ..|||            .:|.::.|...|||..:    .:...:|.....|.|: :||.:..|.:
Human  1582 EAPNA------------PSTVSSGLGAEEPLSSM----TDDMGSPLSTGYHTRSGSEEAVTDPGE 1630

  Fly  2046 TVDGVAHRKQSINSSPPAKGTMLSRKSDCGLPEIRIKAPSIERGAHYYHNHHSGGGSGSLSKHWS 2110
            ...|.:..:..:.:   |...:|.|         |::.|.:|
Human  1631 REAGASLYQGLMRT---ASELLLDR---------RLRIPELE----------------------- 1660

  Fly  2111 YEQVDSAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPI 2175
                        |.|.||:.....: .:|.:.:..:.|:::|:||.::.:|.:|.||..||.||:
Human  1661 ------------EAELFAEGQGRAL-RLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPV 1712

  Fly  2176 MVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI-WSNY---HQLPNQPLTPAKIFGVE 2236
            :||||..||:|||:|.||:|.|.:|:..|::|.:|||... |:::   .:..|:|..|.:|.|:|
Human  1713 LVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLE 1777

  Fly  2237 NKAHYAIYDLILLLVLFLHRYLLKSQGLW------------KSGYKDTDNQ--------FTKPTA 2281
            ....|..|||:.|:.||.||..|...|||            |||.::...:        .|:...
Human  1778 KTDGYIKYDLVQLMALFFHRSQLLCYGLWDHEEDSPSKEHDKSGEEEQGAEEGPGVPAATTEDHI 1842

  Fly  2282 SIDER-DDSDNLSQPDSRQLNDDAAQKLSLQVSQ-----------ASLPGSPEFSKTGINQLE-- 2332
            .::.| ..:|...:|.. :|.....:::||:..:           |::.......:.|..:.|
Human  1843 QVEARVGPTDGTPEPQV-ELRPRDTRRISLRFRRRKKEGPARKGAAAIEAEDREEEEGEEEKEAP 1906

  Fly  2333 --RTKYTS--------------------------SLYKFFFSLVH-KSRLATDVYALMFLCDFVN 2368
              |.|..|                          .|.:||..::| |.|.||||||||||.|.|:
Human  1907 TGREKRPSRSGGRVRAAGRRLQGFCLSLAQGTYRPLRRFFHDILHTKYRAATDVYALMFLADVVD 1971

  Fly  2369 FFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFH 2433
            |.:::|||.|||.....:|  :.:.|::::||..||:|||:||..:|:||||||||.::.|:.|.
Human  1972 FIIIIFGFWAFGKHSAATD--ITSSLSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQ 2034

  Fly  2434 FFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFS 2498
            ...|:.||:||||::||||||.||......::|.:||.|..||:|||:.|||.||||||.||.::
Human  2035 VALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYN 2099

  Fly  2499 MVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRA 2563
            .:|:..|:.:..:|||.|||.::|||..|:|:::..|:.:|||::||::|:|:|::|..:|..:.
Human  2100 HLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKG 2164

  Fly  2564 QKKASLSKLIMGGTIVLLIVICIWGPLCLFAL-GNAVGTSNVPFHVSLSIRIGPYDPIYTTN-NY 2626
            |||..:.|..|||.|:|.::..||.||...:| .:.||..|.|..|::::::|.|:|::|.: ..
Human  2165 QKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQ 2229

  Fly  2627 DSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRN 2691
            .||.....:.|.:::..:..:..|:.||:.|...|:...::.|:|.:||.|:||.|.::..:|.|
Human  2230 PSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYN 2294

  Fly  2692 NHT-LKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNG 2755
            ... :..||:::..|.....|..|...::|.::|..:...|..|..:|..|.|
Human  2295 GTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSD------------ 2347

  Fly  2756 TTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSP-KHYDYRPLVIKMHRDNETNGL----WW-- 2813
                  :.||||.:.||:|:..|..:|..|..|.| :..||..:.|::.|:......    ||
Human  2348 ------QSVVIPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVI 2406

  Fly  2814 ---EIRDYCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASR 2875
               |.|..||                  .:.|..|:||..|.:..||...||:|||.:.||:..:
Human  2407 ELQECRTDCN------------------LLPMVIFSDKVSPPSLGFLAGYGIMGLYVSIVLVIGK 2453

  Fly  2876 FMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2940
            |::.|....:..||||:||.|||:|:||.||:||||..|..|||:|:|||:||||||||:|||||
Human  2454 FVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR 2518

  Fly  2941 PKE 2943
            .||
Human  2519 EKE 2521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Piezo	NP_001303314.1	PIEZO	1226..>1363	CDD:292539	46/137 (34%)
Piezo	NP_001303314.1	Piezo_RRas_bdg	2511..2941	CDD:288978	151/442 (34%)
PIEZO1	NP_001136336.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..769		6/30 (20%)
		PIEZO	1235..1459	CDD:292539	80/516 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1356..1402		24/302 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1462..1498		10/121 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1576..1630		15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1921		16/110 (15%)
		Piezo_RRas_bdg	2111..2519	CDD:288978	151/443 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149572
Domainoid	1	1.000	485	1.000	Domainoid score	I397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1094	1.000	Inparanoid score	I239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46055
OrthoDB	1	1.010	-	-		D13738at2759
OrthoFinder	1	1.000	-	-		FOG0001637
OrthoInspector	1	1.000	-	-		mtm8662
orthoMCL	1	0.900	-	-		OOG6_102664
Panther	1	1.100	-	-	LDO	PTHR13167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3039
SonicParanoid	1	1.000	-	-		X1528
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940