DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Piezo and Piezo2

DIOPT Version :10

Sequence 1:NP_001303314.1 Gene:Piezo / 34112 FlyBaseID:FBgn0264953 Length:2973 Species:Drosophila melanogaster
Sequence 2:XP_036017142.1 Gene:Piezo2 / 667742 MGIID:1918781 Length:2867 Species:Mus musculus


Alignment Length:3352 Identity:861/3352 - (25%)
Similarity:1380/3352 - (41%) Gaps:897/3352 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVFSYACMVLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLT 65
            |.....|.::.|:::|..|.:|...|..|:|||||:...:.|.....|:...:|........|..
Mouse     1 MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKATMQGHTGRLLQSLCI 65

  Fly    66 LSTLVLLGHITLQILAVSL-----TLPIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVF 125
            .|...||.||...|...||     ..|.||||..|:..|.|||.|.........|...||::.:|
Mouse    66 TSLSFLLLHIIFHITLASLEAQHRITPAYNCSTWEKTFRQIGFESLKGADAGNGIRVFVPDIGMF 130

  Fly   126 ATSLGSYLTVKRVASQPVGAE------QLENGEVVDGQ---AENAQTSSQPSAADANG-----GD 176
            ..||..:|..:.:..:|...|      :.||.|:..|:   :|.|....:    |.:|     |:
Mouse   131 IASLTIWLVCRTIVKKPDTEEIAQLNSECENEELAGGEKMDSEEALIYEE----DLDGEEGMEGE 191

  Fly   177 VQQATVTTPLQQQQQQLRKRVSMISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFL 241
            ::::|....|::......|....|...|...|.|.::.|     |..:.::.||:....||.:||
Mouse   192 LEESTKLKILRRFASVASKLKEFIGNMITTAGKVVVTIL-----LGSSGMMLPSLTSAVYFFVFL 251

  Fly   242 LSGTYWATCQTLQRGFALLLRCVMVVLVL----HSLSIVSYQTPWMQSHLNHTTLTARLIGLEPL 302
            ...|:|:.|:|..   .||..|:.|:|.:    |.:.:..||..:.|..:......|||.|::.:
Mouse   252 GLCTWWSWCRTFD---PLLFGCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSV 313

  Fly   303 IESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRLVR--------------- 352
            |::.|:...:: :.|..||...:.||..|...|:.||...:..::..||:               
Mouse   314 IQTDCASTWKI-IVNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPLVQEEMAKEDEGALDCSS 377

  Fly   353 -QSTRKAR------TPQPLESGSSVA-------PS----VTQRGNDMQL---------------- 383
             |:|.:.|      |..|.:....::       ||    ||..||.:..                
Mouse   378 NQNTAERRRSLWYATQYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPIENGPAKT 442

  Fly   384 --------------ESMEQRSEQENTTTSILDQIS---------YGFVSVGGFIYQNSYIFTNIL 425
                          ||.|::.|:|:.......:.|         :..|:|..||.:.|||...|.
Mouse   443 DLYTTPQYRWEPSEESSEKKEEEEDKREDSEGEGSQEEKRSVRMHAMVAVFQFIMKQSYICALIA 507

  Fly   426 MMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELP- 489
            ||||||.||||||||||:.:..||||.|:||..|.||||:|:||..||:.|||:..     ||| 
Mouse   508 MMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSF-----ELPE 567

  Fly   490 -TSVPTAGINLQQIGF---ERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLAD 550
             ..||         ||   :.|.|        |..|..|.:.||:..||...|::..|....|  
Mouse   568 IKKVP---------GFLEKKEPGE--------LASKILFTITFWLLLRQHLTEQKALREKEAL-- 613

  Fly   551 FIAPLQITVGSAGSSYLIN----------DGKKTSK----------------------------- 576
             ::.::|     ||..|..          :|:.|.|                             
Mouse   614 -LSEVKI-----GSQELEEKDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQ 672

  Fly   577 -FLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIM 640
             .:|..|:::..|.::.||::...:.|..:..|: :..::|.||.||||.:.::|...:.|.||:
Mouse   673 DIMKVLGNLVVALFIKYWIYVCGGMFFFVSFEGK-IVMYKIIYMVLFLFCVALYQVHYEWWRKIL 736

  Fly   641 YGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIV 705
            ..||:.::.|.|.:||.||||||:.|...|.:...:.....:|:|||::...:||..:..||..:
Mouse   737 KYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFL 801

  Fly   706 ILTVIQVHYFHKRFI------------------------------------ASLQQQPLA--GGS 732
            ::.::.:||||.||:                                    ..:.|..||  .||
Mouse   802 LVCILHLHYFHDRFLELTDLKSIPSKEDNTIYSHAKVNGRVYLIINSIKKKLPIHQNELAHPEGS 866

  Fly   733 AQ----------------QKPTETTALEPAPSKRRGSAGSLRKSQGPSAEAAPGATTDFETSVRD 781
            ..                ||..|:....|....::...|...|....|.|.........|....|
Mouse   867 LPDLAIMNMTASLDKPEVQKLAESGEERPEECVKKTEKGEAGKDSDESEEEEDEEEESEEEESSD 931

  Fly   782 LVRISFRKIKNKSEYIFKNFKDVF-------WRFLELHIMKAVYIAAFVCSVSEVCVLHIIFV-- 837
            | |..:..:.::...:|..|.:.|       |..|||||:|.|.......:|.||.:.:.:|:  
Mouse   932 L-RNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVTVKEVSLFNYVFLIS 995

  Fly   838 -GFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCS---DNRT------- 891
             .|.:..|..|:|.    |.:.:....||::.||:||::.:.....:|.||   :|:|       
Mouse   996 WAFALPYAKLRRAA----SSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPLHEL 1056

  Fly   892 ---------ANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAP 947
                     .:..||:||.|:..    |:..||..::.:.|:.....:...|...|.: ..|.||
Mouse  1057 NKSLLYSAPVDPTEWVGLRKSSP----LLVYLRNNLLMLAILAFEVTVYRHQEYYRGR-NNLTAP 1116

  Fly   948 PTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLV-VL 1011
            .:|.:|.:|.|...:..|:...||.:|:.|||||:|...:..|:.|..|.|..|:::|.||: ||
Mouse  1117 VSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIGVL 1181

  Fly  1012 LLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWD-EGP-FGEGIQRWAMLPGALH 1074
            ...||...|::|..:..|.|..|..||.|.:|:||:.|..:||. :|. |.:.|.:|...|..:.
Mouse  1182 YRRRRKAIAEVWPKYCCFLACIITFQYFVCIGIPPAPCRDYPWRFKGAYFNDNIIKWLYFPDFIV 1246

  Fly  1075 FNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVI--ADIAQLGRVPFDNPTHDF 1137
            ..:...|::||::|:..:.|:.||..|.:.|..  ...|.|..:.  .|.|...:   .||..||
Mouse  1247 RPNPVFLVYDFMLLLCASLQRQIFEDENKAAVR--IMAGDNVEICMNLDAASFSQ---HNPVPDF 1306

  Fly  1138 CSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTII 1202
            . :.|:|.|:.|..:....:||.|.::|:.||....:..:|||:..|.||..|.|..|:||.:|:
Mouse  1307 I-HCRSYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSIL 1370

  Fly  1203 FRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAELAL 1267
            ..|.||:|:||..|.:|....:..|.::..|.::.|||:....:.||    .:...:||:     
Mouse  1371 RYWDWLIAYNVFVITMKNILSIGACGYIGALVRNSCWLIQAFSLACT----VKGYQMPED----- 1426

  Fly  1268 KPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQI 1332
             ...|...:.:..::||:|||||::.|.|:|.|:||.|::.|.||:.|||||||::.::...|.:
Mouse  1427 -DSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAV 1490

  Fly  1333 AHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAMSDVAPLVHNSSFTSCQ 1397
            ..|.:.||:.:.::||:|:||:|.|||..:..::..                       |.|...
Mouse  1491 KARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERML-----------------------SLTQES 1532

  Fly  1398 GSGYLTPDEHSSATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYVDVQS 1462
            |.|.                                                         |:|.
Mouse  1533 GEGQ---------------------------------------------------------DIQK 1540

  Fly  1463 VSEEETTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLAPPELSP 1527
            ||||:                                                            
Mouse  1541 VSEED------------------------------------------------------------ 1545

  Fly  1528 PVGMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSIKRSPMKKQ 1592
                                                                           .:
Mouse  1546 ---------------------------------------------------------------DE 1547

  Fly  1593 MSADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARDEAALRSAQRPHSWGP 1657
            ..|||::                          ::.::|:                      |  
Mouse  1548 READKQK--------------------------AKGKKKQ----------------------W-- 1562

  Fly  1658 VGTSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEIDFLEEE---------- 1712
                          :.|.:.|....|:||||:||...::.|    .:|:...:||          
Mouse  1563 --------------WRPWVDHASMVRSGDYYLFETDSEEEE----EEELKKEDEEPPRKSAFQRA 1609

  Fly  1713 ---------NITESEMKMQR---------RKTLYDVW---------------KDLNDAEYRRHFY 1744
                     .:.:|.:|:.:         .|.:|..|               |.|...|      
Mouse  1610 IGKFASAILALPKSVIKLPKTILQYLIRAAKFVYQAWITDPKTALRQRRKEKKKLAREE------ 1668

  Fly  1745 MRERSYASEPGSRILLKLDDE---KEKIGPD---------------LGLASDHDEDDDTIECDLG 1791
            .:||...|..|.......:||   |:..|||               |.||        |::....
Mouse  1669 QKERRKGSGDGPVEWEDREDEPVKKKSDGPDNIIKRIFNILKFTWVLFLA--------TVDSFTT 1725

  Fly  1792 MRTSTLSEPLDFG-----RRSQTLLEVKSKDAPTGE-----FPSTSKGISKERDAAT------AS 1840
            ...|...|.:|..     .|.....|:|..:.||.|     :.:....:|:|....|      |.
Mouse  1726 WLNSISREHIDISTVLRIERCMLTREIKKGNVPTRESIHMYYQNHIMNLSRESGLDTIDEHSGAG 1790

  Fly  1841 SSASPAPTRDVGDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSD-EDFD-TNPIIR 1903
            |.|..|...|                   |.::.||.|....::..:.::.|. :|.| .:|:.:
Mouse  1791 SRAQAAHRMD-------------------SLDSRDSISSCYTEATLLISRQSTLDDLDGQDPVPK 1836

  Fly  1904 LLEGFLVTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESE 1968
            ..|                         ..:..|::..||:   :||::|            :|.
Mouse  1837 TSE-------------------------RARPRLRKMFSLD---MSSSSA------------DSG 1861

  Fly  1969 PPASSSTPRRVVIAPPNATEHSDPTSTTL-----NTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQ 2028
            ..||                 |:||..|:     .|..|...:......:.::.|:|......::
Mouse  1862 SVAS-----------------SEPTQCTMLYSRQGTTETIEEVEAEAEEEVVEGLEPELHDAEEK 1909

  Fly  2029 QH--QHIRAAEEII-----ELP---VDTVDGVAHRKQSINSSPPAKGTMLS-------RKSDCGL 2076
            ::  ::....|||.     |||   .|..|..|         ||:....:|       .:.|.|.
Mouse  1910 EYAAEYEAGVEEISLTPDEELPQFSTDDCDVEA---------PPSYSKAVSFEHLSFASQDDSGA 1965

  Fly  2077 PEIRIKAPSIERGAHYYHN------HHSGGGSGSLSKHWSYEQVDSAGEFNLEEENFAQRDHHII 2135
            ....:.:|...|......:      |........:||.:..::::.:.:|.:::..|.       
Mouse  1966 KNHMVVSPDDSRTDKLESSILPPLTHELTASDLLMSKMFHDDELEESEKFYVDQPRFL------- 2023

  Fly  2136 VEVLISSWY-ALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAY 2199
              :|..:.| .|:|.::::||.|:.:|.:.:||:|:|.|||::|||..||:|||::.||:..|.|
Mouse  2024 --LLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVY 2086

  Fly  2200 TQAIVLIKCIFQFKLI-WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQ 2262
            |:..:::|..|||... |:...:: ..:|..|..|.|||.|..|.:||||.||.||.||.:||..
Mouse  2087 TEVAIVVKYFFQFGFFPWNKDLEIYKERPYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCH 2151

  Fly  2263 GLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASL----PGSP-- 2321
            |||     |.|:.....|   |:....|.||....|:.:.|:.:.::|..|..|:    |..|  
Mouse  2152 GLW-----DEDDIVDSNT---DKEGSDDELSLDQGRRGSSDSLKSINLAASVESVHVTFPEQPAA 2208

  Fly  2322 --------------------EFSKTGINQLERT-------------------------------- 2334
                                ..||.|......:                                
Mouse  2209 IRRKRSCSSSQISPRSSFSSNRSKRGSTSTRNSSQKGSSVLSLKQKSKRELYMEKLQEHLIKAKA 2273

  Fly  2335 ---KYTSSLY----KFFFSLVHKSRLA-TDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQ 2391
               |.|..:|    :||:.|:|....| ||||.||||.|.|:|.:::|||.|||.....:|  :.
Mouse  2274 FTIKKTLQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAAD--IT 2336

  Fly  2392 TYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTF 2456
            :.|:|::||.|||:|:|:||..:|:||||||||.::.|:||....|.|||.||||::|.||||.|
Mouse  2337 SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKF 2401

  Fly  2457 NSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTIL 2521
            :......::|.:||.|..||:|||:.|||.|:||||.||.::.||:..|:.:..:|||.|||.::
Mouse  2402 SQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVM 2466

  Fly  2522 DWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICI 2586
            |||..|:|:::..|:.:|||:::|::::|.|:||..:|..|.|||....|..|||.|::|::..:
Mouse  2467 DWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIV 2531

  Fly  2587 WGPLCLFALGNAV-GTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFEI-NPEMYSQMTNAYIKEKQ 2649
            |.||...:|..:| |..|.|..||::|.:|.|.||:|.:...|..:: :...|::...::.....
Mouse  2532 WFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSG 2596

  Fly  2650 ALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRN-NHTLKARFSYSLTRKAPAKGLK 2713
            |:.|:..|:..||....|.|||.|||.|:||.:|:::.:|.: |......||:|:.|..      
Mouse  2597 AMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNM------ 2655

  Fly  2714 ENVGDEHAISLDE-SFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVL 2777
             .:|.:..|:.|: ||....|..:.:::.     |..|.|.:..||     |.|..:.|.::|..
Mouse  2656 -TLGAKAEIATDKLSFPLAVATRNSIAKM-----IAGNDTESSNTP-----VTIEKIYPYYVKAP 2709

  Fly  2778 NSGDAAVVSVLSPKHYDYRPLVIKMHRDNET--NGLWWEIRDYCNDTFYNETLSKFAYSNCTSGI 2840
            :..::..:..|..:: ::..:.|.:.|||.|  |..||.:         |.|.|:. ::..:..:
Mouse  2710 SDSNSKPIKQLLSEN-NFMNITIILFRDNVTKSNSEWWVL---------NLTGSRI-FNQGSQAL 2763

  Fly  2841 VMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLD 2905
            .:..||||..|.:..||...||:|||.:.||:..:|::.|..|.:..||||:||.|||:|:||.|
Mouse  2764 ELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTD 2828

  Fly  2906 IYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPK 2942
            |:||||..|..|||||:|||:||||||||:|||||.|
Mouse  2829 IFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PiezoNP_001303314.1 PIEZO 1226..>1386 CDD:464941 47/159 (30%)
Piezo_RRas_bdg 2511..2941 CDD:463481 154/435 (35%)
Piezo2XP_036017142.1 PIEZO 1393..1660 CDD:464941 80/547 (15%)
Piezo_RRas_bdg 2455..2864 CDD:463481 154/436 (35%)

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