Protein Alignment Piezo and si:dkey-11f4.7

DIOPT Version :9

• Sequence 1: NP_001303314.1
• Gene: Piezo / 34112
• FlyBaseID: FBgn0264953
• Length: 2973
• Species: Drosophila melanogaster
• Sequence 2: XP_021334475.1
• Gene: si:dkey-11f4.7 / 569687
• ZFINID: ZDB-GENE-070912-361
• Length: 2634
• Species: Danio rerio
• Alignment Length: 3171
• Identity: 779/3171 - (24%)
• Similarity: 1309/3171 - (41%)
• Gaps: 779/3171 - (24%)

  Fly    12 RIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFF-------IILLTLSTL 69
            |:....|...|..:|..|:|.||||.....|.:|.......||....|.       :|.|.|...
Zfish     5 RLPCCCVRARAISVRFSGLSVVYLLFLLSFPLIPTPNTATIKGKSGRFLRTVCSTGVIFLALQCG 69

  Fly    70 VLLGHITLQILAVSLTLPIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVFATSLGSYLT 134
            :   .||...:....|.|..:..|      |:|.|.|.::....||..|.|:|:|..::|.....
Zfish    70 M---QITFAYVPKDETGPWDDVFF------HLGIVRFSEVDTLNIIRLLTPDVVVSVSTLFIIRW 125

  Fly   135 VKRVASQPVGAEQLENG-----------EVVDGQAENAQTSSQPSAADANGGDVQQATVTTPLQQ 188
            .|  |.:|   .|.|:|           |:.|.:.|.....|:.|:.|.: .:.:.:...:|  .
Zfish   126 CK--ARKP---HQSEDGRAMYSTEGSDEEMSDSECEAESRGSEDSSFDTS-AETRISPDASP--D 182

  Fly   189 QQQQLRKRVS----MISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWAT 249
            ..|:|...||    ::|..::..|.|.::.|..||.:.|     |.:....||.:||:  ..|
Zfish   183 VLQKLILFVSGLRLLVSSLMNSAGRVLVTFLLGLAGITF-----PCLTSALYFSVFLV--LVW-- 238

  Fly   250 CQTLQRGFALLL---RCVMVVLVL--HSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLIESYCSP 309
            |..|....:||.   .|||:.:..  |.|.:..||.|..|..:......:||.||..||::..|.
Zfish   239 CWVLDFSISLLFFSSLCVMMTIFSGGHVLILYLYQLPLAQQIIPPHDHFSRLFGLTALIKTNMSE 303

  Fly   310 DIRVFLYNNKLSLDSYLNPFALFFAYFAL-----------------------ALTTKHLIK-PRL 350
            ...:.|:.:. |..:.:||..|...||.:                       :|:..|... .|.
Zfish   304 PYSLILHEDS-SWPAVVNPLVLLLLYFTVMSLLHKWAHSVNQENAENYAEGSSLSKMHNFPLERR 367

  Fly   351 VRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTT--------SILDQIS--- 404
            |.....:.....|.:||.::... ....|...|....|:...|.|..        .||:.:.
Zfish   368 VEAMVWRRTWQDPEDSGVNLLLE-DDYANCFALSPYTQKISYEYTVEKESCDGGHEILNDVDPPP 431

  Fly   405 -----YGFVSVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPF 464
                 ...|.:|.||.:.|||...|:.|.|||.|:||||.|:|:.:.|:||:.::|:..|.|:||
Zfish   432 DQSGPSAVVLLGQFIMKQSYIIALIITMVWSICYNSWLTLVMLVWSCVIWMLKDRRRFAMLSAPF 496

  Fly   465 IVLYAEALLIAQYIYGMDLNN-EELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMF 528
            :.:|...|||..:|..:.|.: ...||......|:....|:  |:     |||.|..|.::...|
Zfish   497 LAVYGTLLLIISFISQLHLKHIAVFPTLPKLVLIDFDAYGY--PV-----PCVHLAAKVSYSFSF 554

  Fly   529 WVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLW 593
            |:..||...||.:....:  .|.:..:::..         .|...:|..:...|.::|.:||:.|
Zfish   555 WILLRQRLIEKHEEELQN--EDELKEVKVQA---------RDSSNSSPIIVVLGSLVKGMLVKYW 608

  Fly   594 IWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILI 658
            |:....:.|..:.: :.:..::|.|:.||||.:::::.....|...:..||..::.|:|.:||||
Zfish   609 IFCCCFMFFYVSFS-DKVAVYKILYICLFLFGVVLYEVHYDVWRSQLKYFWAVVVGYSMLVLILI 672

  Fly   659 YTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRF--IA 721
            |.|||......:...|.:|....:|:||:::.|.:||..::.|...::..::|:|||:..|  :.
Zfish   673 YIYQFKSVCKLFQQILGLSEESLRDLGLEQFDTVELFARILRPAFFLLACILQLHYFNSDFLCLT 737

  Fly   722 SLQQQPLAGGSAQQKPTETTALEPAPSKRRGSA--------GSLRKSQGPSAEAAPGA-----TT 773
            .|........:.:::..:.|........::.|.        |.||..|......:...     ..
Zfish   738 DLNTVTTTNRAKREEDLKETLQGVFDIMKKSSEKLKTWLKDGQLRGKQADQMNTSSSTLDEHQEL 802

  Fly   774 DFETSVRDLVRISFRKIKNKSEYIFK------NFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVL 832
            |.|..|..:|:.....::...|.|.:      ..:::.||.||||..|.|........|.||.::
Zfish   803 DSEDDVPVVVQQWLLVLERLHELILRFVLLLWRVQELCWRLLELHSFKLVSTGIIWVCVKEVSLM 867

  Fly   833 HIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSDNRTANNAE- 896
            :.:|:..... |.....::.|...:.|....|:|:.||:||::.:..|:::..|:...:::|..
Zfish   868 NFVFLVLWTF-ALPYPRLRPVAFNVSSVWACVMVVCKMMYQLKSIKPSEYSSNCTAGLSSSNESG 931

  Fly   897 -----------------------WIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMR 938
                                   |:|..|  |....::..|..:::.:.::.:...:...||..|
Zfish   932 TLDVPADLLGNSVLYSAPVDPFMWVGGLK--KCEDRILPCLWNHLLILGLLVVDVTVHRHQLHHR 994

  Fly   939 VKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVV 1003
            ::.| |....:.::|..:.....:..::..|||.:|:.|||||:|:..:..|:.|..|.|:.|::
Zfish   995 LQHG-LKTANSSIIFQAVTHHHLDHGILPSVKYFVNYFFYKFGLEVCFVVAVNVIGQRMDLCALL 1058

  Fly  1004 YALWLVVLLLLRRSQC-AKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPW-DEGP-FGEGIQR 1065
            ::|.|:|:|..||.:. .::|..:.:|.|..::.||::.:|:||:.|..:|| ...| ....:.:
Zfish  1059 HSLALMVVLARRRRKAIGEVWPKYCSFIASFMVLQYLLCIGVPPALCSDYPWRSSSPALSSNLIK 1123

  Fly  1066 WAMLPGALHFNHVPKLIFDFIVLVILNRQKSIF------CIEQRYASNDDYPGGSNRSVIADIAQ 1124
            |..||......:...:::|.::|::.:.|..:|      |:......|.:.    :|::  |...
Zfish  1124 WLYLPDHAMSPNATFILYDCLLLLVASLQWKVFEEENQACVRLLAGENVEI----SRNL--DPQT 1182

  Fly  1125 LGR-VPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLW 1188
            |.: .|.:|..|  |   |:|.|::|..|...|:|..|.::|:.||...::|.||||:..|.|:.
Zfish  1183 LNQYTPVNNFLH--C---RSYLDMVKVFVFSYFFWLVLCLIFITGTTRINMLCLGYLVACFYFML 1242

  Fly  1189 QGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVL 1253
            .|....|:|:..::..|..|:|:....|.:|....:..|.::..|.|..|||:....:.||
Zfish  1243 FGGTLLLQPVQYVLRLWDALIAYTCVVISLKNLLSLGSCAYLDPLQKHGCWLIQAFSMFCT---- 1303

  Fly  1254 TEQIMLPE-EAELALKPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILA 1317
            .:...||: :::..|..||..       ::||.|||..::.|.|:|.|:||.::::|.:.:.|||
Zfish  1304 IKGYSLPKPDSQCELPEGEAG-------IIWDAICFTVLLAQRRVFLSYYFLYVVSDLQTSKILA 1361

  Fly  1318 SRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAMS 1382
            ||||::.|:...||:|.|.:.|.:.:..:|::||:|::.|    .|..:|.
Zfish  1362 SRGAELFEAKVKKQVAARLEMEIKSVEILKKQMEKIKSKQ----NPPPQQV-------------- 1408

  Fly  1383 DVAPLVHNSSFTSCQGSGYLTPDEHSSATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEIN 1447
                                           :||||                        .||.:
Zfish  1409 -------------------------------SSSPA------------------------HPESS 1418

  Fly  1448 VMP------CDEITDYVDVQSVSEEETTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLL 1506
            .:|      |.  .|..|..|..|||..     ||.:
Zfish  1419 HLPKRKDGDCG--YDMFDTDSEEEEEEV-----KDRA---------------------------- 1448

  Fly  1507 TEGFLEPKRISLGLAPPELSPPVGMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSS 1571
            .|..|..|:.:..|                   ||...:|...|
Zfish  1449 QESILPMKKTAFQL-------------------AYEAWVAGPKA--------------------- 1473

  Fly  1572 TNAAVSWNETVSIKRSPMKKQMSADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSN 1636
              |..::|:         ::|....||:      :.|||
Zfish  1474 --ALNAYNQ---------QEQEETSKEK------RKLHR-------------------------- 1495

  Fly  1637 LSGARDEAALRSAQRPHSWGPVGTSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDL 1701
                                                                  :|..||.|.:
Zfish  1496 ------------------------------------------------------QEGIDKDEPE- 1505

  Fly  1702 IHDEIDFLEEENITESEMKMQRRKTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEK 1766
                 :.|:||::.|.|.:.:|...            :||...|.:..:.      .||:|.:
Zfish  1506 -----EELQEESLKEEEGEEEREHI------------FRRILDMLKFLWV------FLLRLTE-- 1545

  Fly  1767 EKIGPDLGLASDHDEDDDTIECDLGMRTSTLSEPLDFGRRSQTLLEVKSKDAPTGEFPSTSKGIS 1831
            :.|.....|..|               :..:|:.|.|   .:|||.::.           :||
Zfish  1546 DAISGLNALCKD---------------SLNISKVLRF---EKTLLSIQQ-----------NKG-- 1579

  Fly  1832 KERDAATASSSASPAPTRDVGDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDF 1896
                             |||....:.....|.|.|::| ::|.|::.:   |..|:|.
Zfish  1580 -----------------RDVNHESIHKFYKTWLSRQET-EDTLDTEKE---DVKEMTC------- 1616

  Fly  1897 DTNPIIRLLEGFLVTLTIRLNRFSRNYRFVN----------------RILAGEKKTLKESSSLNR 1945
             :.|.:              :.:.|.|..:|                .:|...:.||.:...|:
Zfish  1617 -SPPAV--------------SSYPRGYVKLNSLHSWGSSLSSCQTDDTLLVTRQPTLDDVDELD- 1665

  Fly  1946 LGLSSAAAMFHFLKSNLESDESEPPASSSTPRRVVIAPPNATEHSDP--------TSTTLNTNTT 2002
                         .:.|:|::....|.|.|       |..:.|..||        ...|...||.
Zfish  1666 -------------FTPLDSEQHCGDAQSET-------PDISKERKDPDKGCEMLTDGWTHEENTA 1710

  Fly  2003 TTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRA--AEEIIELPVDTVDGVAHRKQSINSSPPAKG 2065
            ...|:.......|..::...|..|:..:|..||  |.|::                :|:.
Zfish  1711 DIVLTEFPKQMNLHQVEKEETPEPRTLNQETRALTASELL----------------LNNI----- 1754

  Fly  2066 TMLSRKSDCGLPEIRIKAPSIERGAHYYHNHHSGGGSGSLSKHWSYEQVDSAGEFNLEEENFAQR 2130
                           ...|.||....:|.:...|
Zfish  1755 ---------------FDIPEIEESDRFYSSLPRG------------------------------- 1773

  Fly  2131 DHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVT 2195
                 :.::.:.:..:.:.:::.||.|:..|.||:|||::|.|||::|||..:|:|||||.||:|
Zfish  1774 -----LRLVFALYNLMESQSEMFCYFVMIFNHVVSASLLTLFLPILIFLWAMMSVPRPTKRFWMT 1833

  Fly  2196 LIAYTQAIVLIKCIFQFKLI-WSNYHQL----------PNQPLTPAKIFGVENKAHYAIYDLILL 2249
            .|.|||..|::|..|||... |:....|          ||       |.|||.|..|.:.|||.|
Zfish  1834 AIIYTQLTVVVKYFFQFGFFPWTTSAYLGINAERAFAVPN-------IVGVEKKDGYVLVDLIQL 1891

  Fly  2250 LVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQK---LSLQ 2311
            :.||.||.:||..|||.:...:..:.|.|.     :|....|.....|||..::.:::   |.||
Zfish  1892 IALFFHRSILKCHGLWDNKEVEMPDFFKKL-----KRKTEKNKMTGGSRQREENTSRRIPFLPLQ 1951

  Fly  2312 VS--QASLPGSPEFSKTG---------------INQLER-TKYTSS------------------- 2339
            ||  :.....|||.:..|               :::.|| .||.:.
Zfish  1952 VSFLRRQRAESPERAADGHQMRKKRSQKKRSVPLSRKERMKKYMNDRLLEAKAAVIELALHIYLP 2016

  Fly  2340 LYKFFFSLVH-KSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPF 2403
            :.:||:.::| :.....||||||||.|.|||.:::||:.|||.....:|  :...|:|::||..|
Zfish  2017 IRQFFYDIIHPEYSPVCDVYALMFLIDVVNFIIIIFGYWAFGKHSAAAD--ITESLSEDQVPEAF 2079

  Fly  2404 LIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVI 2468
            |:|||:||..:::||||||||.|:.|.:|....|.|||.||||::|.||||.||......::|.:
Zfish  2080 LVMLLIQFSTMIVDRALYLRKTLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNRVAQLWYFV 2144

  Fly  2469 KCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIF 2533
            ||.|..||:||||.|||.|:||||.||..:..|:..|:.:..:|||.|||.::|||..|:|:::.
Zfish  2145 KCIYFGLSAYQIKCGYPNRVLGNFLTKNHNYFNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLS 2209

  Fly  2534 DWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNA 2598
            :|:.:|||::||::::|.|::|..:|..|.|:|..:.|..|||.|:..::..:|.||...:|..:
Zfish  2210 NWICVEDIYANIFILKCWREAEKKYPHRRGQRKKKVVKYTMGGFIIFALICIVWFPLLFMSLVKS 2274

  Fly  2599 V-GTSNVPFHVSLSIRIGPYDPIYTTNNYD-SIFEINPEMYSQMTNAYIKEKQALTFIAGYDATD 2661
            | |.:|.|..||:.:.|..|:|:::.:..: ::...:...:.:|||.:.....|:.||..|.|.|
Zfish  2275 VAGVTNQPLDVSIQLSILGYEPLFSMSAQEHNLIPYSQSAFQKMTNRFATYPSAMQFIVNYMAED 2339

  Fly  2662 VAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDE 2726
            :...::..::..||:::|..|..::::|.|:........::|.|.|......|..| ||.:
Zfish  2340 IVTAKIKSDASLLWSVSPASRDAMISELSNSTHFYITLRWTLLRNASVSMNAETAG-EHTV---- 2399

  Fly  2727 SFEGRA---ALIHMLSETHDVEPIY---SNGTTNGTTPEVEEVVVI---------PGMIPKFIKV 2776
            .:|.||   .|:.||..|| ..|:|   ::...:|....:....||         ..::||:|:.
Zfish  2400 KYEDRALRDQLVAMLRGTH-TRPLYTLLTHTLKHGVFLMILSAHVICFLLSVRLLENLLPKYIRG 2463

  Fly  2777 LNSGDAAVVSVL------SPKHYD---YRPLVIKMHRDNETN----GLWWEIRDYCNDTFYNETL 2828
            .:..:|.|...|      .|::.|   .|||.:.:.:.|.::    ..||.::         |..
Zfish  2464 ASGPNAKVAHRLQVEFSREPENADLQFLRPLSVSLQQGNRSSPDSAPQWWVVQ---------ECW 2519

  Fly  2829 SKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDL 2893
            .....|:|.| |.|..||||..|.:..||...||:|||.:.||:..:|::.|..|.:|.||:|:|
Zfish  2520 PGPPPSSCRS-IEMVVFNDKASPPSVGFLAGYGIVGLYMSVVLVIGKFVREFFTGISRSIMYEEL 2583

  Fly  2894 PYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEE 2944
            |.|||||:||.||::||||.|..:||.:|.||:||||||||:||.|..|.:
Zfish  2584 PCVDRVLKLCNDIFIVREAGEMEMEEQMFEKLIFLYRSPETMIKMTHNKSD 2634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Piezo	NP_001303314.1	PIEZO	1226..>1363	CDD:292539	43/137 (31%)
		Piezo_RRas_bdg	2511..2941	CDD:288978	150/459 (33%)
si:dkey-11f4.7	XP_021334475.1	PIEZO	1279..1475	CDD:318189	69/356 (19%)
		Piezo_RRas_bdg	2186..2629	CDD:314954	149/458 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13738at2759
OrthoFinder	1	1.000	-	-		FOG0001637
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920