DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Piezo and Piezo1

DIOPT Version :9

Sequence 1:	NP_001303314.1	Gene:	Piezo / 34112	FlyBaseID:	FBgn0264953	Length:	2973	Species:	Drosophila melanogaster
Sequence 2:	XP_008770848.1	Gene:	Piezo1 / 361430	RGDID:	1308822	Length:	2537	Species:	Rattus norvegicus

Alignment Length:	3169	Identity:	811/3169 - (25%)
Similarity:	1298/3169 - (40%)	Gaps:	882/3169 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLTLSTLVLLGHITL 77
            :::|..|:.|:|:|...:|.||||...:.|::|..:|.:..|........||.||.|.|:.|:..
  Rat    13 LLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLLRALLCLSLLFLVAHVAF 77

  Fly    78 QILAVSLTLPI------YNC-SFSERLLRHIGFVSFIDLQP-FAIIEWLVPEVLVFATS---LGS 131
            ||..  .|:|.      .|| |....:.:||| |:.:||:. |.....:.|::.|...|   ||.
  Rat    78 QICL--HTMPRLNQLLGQNCSSLWANVSQHIG-VTRLDLKDIFNTTRLVAPDLGVLVASSLCLGL 139

  Fly   132 YLTVKRVASQPVGAEQLENGEVVDGQAENAQTSSQPSAADANGGDVQQA-TVTTPLQQQQQQLRK 195
            ...:.|.|.|....::|:..:.:|             ||.|.|  :|.| |:.|   :::..|..
  Rat   140 CGRLTRKARQSQRTQELQEEDDID-------------AAPAAG--LQGAPTLAT---KRRLWLAP 186

  Fly   196 RVSMISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQR-GFAL 259
            |..:.:..:    ||....:..:..|..|.:..||.....|.::||...|:|:....|.. ||..
  Rat   187 RFRITAHWL----LVTSGRMLVIVLLALAGIAHPSAFSSVYLMVFLAICTWWSCHFPLSSLGFNT 247

  Fly   260 LLRCVMVVL--VLHSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLIE--SYCSPDIRVFLYNNKL 320
            |  ||||..  ..|.:.:..||||::||.|...:|.|||.||:..::  :..||::.|.  |.|.
  Rat   248 L--CVMVSCFGAGHLVCLYCYQTPFVQSVLLPGSLWARLFGLKNFVDIPNCSSPNVLVL--NTKH 308

  Fly   321 SLDSYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKAR---------------TPQPLESGSSV 370
            :...|::|..|...|:    |...|:|.|..|.|..:..               .|:|...|::.
  Rat   309 AWPIYVSPGILLLLYY----TATSLLKLRKGRFSELRKEIPREDEEHELELDQLEPEPQARGTTQ 369

  Fly   371 APSVTQRGNDMQLESMEQRSEQENTTTSILDQIS--------------------YGFVSVGGFIY 415
            ..:.|..|.|:           :|.|..:|...|                    :|   :|..|.
  Rat   370 GATPTTTGPDI-----------DNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLHG---LGHLIL 420

  Fly   416 QNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYG 480
            ..||:...|.||.|||:|||||||||||.|.::|.:.::.:..|..||.|:||...|...:|::.
  Rat   421 DQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGLTLCCLRYVWA 485

  Fly   481 MDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEK--RDRR 543
            |:|  .||||::  ..::|.|:|    :|:...||:.|.....::|.||:..|||.|||  :.|:
  Rat   486 MEL--PELPTTL--GPVSLHQLG----LEHTRYPCLDLGAMLLYLLTFWLLLRQFVKEKLLKKRK 542

  Fly   544 RDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITG 608
            ..|||      |::||..       .:..:|...|:..|:::..:.|:.||::...:..:.:..|
  Rat   543 APSTL------LEVTVSD-------TEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFAG 594

  Fly   609 ENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDY 673
             .:..::|.||.|||..|.:||.....|.|::..||..::.|.|.:||.:||:||..|.|||.:.
  Rat   595 -RLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPTYWRNL 658

  Fly   674 LNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRF--IASLQQQPLAGGSAQQK 736
            ...:.....|:||:::...:||..::.|...::..::|:||||:.|  :..|:..|..|....:.
  Rat   659 TGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHVPPPGTRRLRW 723

  Fly   737 PTETTALEPAPSKRRGSAGSLRKSQGPSAEAAPGATTDFETS-----------VRDLVRISFRKI 790
            ......:..||..:......:.:..|.|.: .|..||.....           :.||.. ||..:
  Rat   724 AHRQDTVSEAPLLQHQEEEEVFRDDGQSMD-GPHQTTQVPEGTASKWGLVADRLLDLAS-SFSAV 786

  Fly   791 KNKSEYIFKNFKDVFWR-FLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATS--RKAVQV 852
            ..:.:        ||.| .||||:.|.|.:.....::.||.|::::.|   ||.|.:  ....:.
  Rat   787 LTRIQ--------VFVRCLLELHVFKLVALYTVWVALKEVSVMNLLLV---VLWAFALPYPRFRP 840

  Fly   853 VISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSD---NRT----------------ANNAEWI 898
            :.|.|.:....:|::.||:||::.::..:::..|::   |.|                .:.|.|.
  Rat   841 MASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEISQSLLYRGPVDPANWF 905

  Fly   899 GLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAP-PTKLLFPNIIRADAE 962
            |:.|.....|    .::.::..::::...||:..||...|.:  ...|| |.:.|..:..|...:
  Rat   906 GVRKGYPNLG----YIQNHLQILLLLVFEAVVYRRQEHYRRQ--HQQAPLPAQALCADGTRQRLD 964

  Fly   963 KDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQC-AKIWGVF 1026
            :||:..:||.:||.|||||:||..:..|:.|..|.:.:.:::..|||.:|..||.:. |::|..:
  Rat   965 QDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNY 1029

  Fly  1027 QAFFAISILTQYIVLVGLPPSSCLVFPW---DEGPFGEGIQRWAMLPGALHFNHVPKLIFDFIVL 1088
            ..|..:.:|.||::.:|:||:.|:.:||   ...|....:.:|..||......:...||.||::|
  Rat  1030 CLFLTLFLLYQYLLCLGMPPALCIDYPWRWSQAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLL 1094

  Fly  1089 VILNRQKSIFCIE-----QRYAS-NDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDI 1147
            :..::|..:|..|     ||.|. |.|:           :..|...|  ||..:|. :.|:|.|:
  Rat  1095 LCASQQWQVFSAEQTEEWQRMAGVNTDH-----------LEPLRGEP--NPIPNFI-HCRSYLDM 1145

  Fly  1148 LKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFN 1212
            ||..|....:|..|.|||:.|.....:..||||:..|..|..|:....:.....:..|..|:.:|
  Rat  1146 LKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYN 1210

  Fly  1213 VANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPGECPKITH 1277
            |..|:.|....:..|:|:.|:..:.||::.:..:.||.....:    |:  |:..:..:|.....
  Rat  1211 VTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD----PK--EMKTRDRDCLLPVE 1269

  Fly  1278 QVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQV 1342
            :..::||:|||.|::.|.|:|.||||.|:..|.||..:.||||..:..:...|.|......|::.
  Rat  1270 EAGIIWDSICFFFLLLQRRVFLSHYFLHVSADLKATALQASRGFALYNAANIKNINFHRQTEERS 1334

  Fly  1343 LHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAMSDVAPLVHNSSFTSCQGS-GYL---T 1403
            |.::||:|:||||.|:|                                 :...|.| |.|   .
  Rat  1335 LAQLKRQMKRIRAKQEK---------------------------------YRQSQASRGQLQSTD 1366

  Fly  1404 PDEHSSATSGTSSPAR----------ASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYV 1458
            |.|....:.|.|||.|          |:::.|.                             ||.
  Rat  1367 PQEPGPDSPGGSSPPRTQWWRPWQDHATVIHSG-----------------------------DYF 1402

  Fly  1459 DVQSVSEEETTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLAPP 1523
            ..:|.||||                      |.:.|..|.
  Rat  1403 LFESDSEEE----------------------EEALPEDPR------------------------- 1420

  Fly  1524 ELSPPVGMQCLAPPLAAYATAMASSA----ASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSI 1584
                         |.|..|..||..|    |.:||      ..|||..|:.......|..:.
  Rat  1421 -------------PAAQSAFQMAYQAWVTNAQTVL------RQRREQARRDRAEQLASGGDL--- 1463

  Fly  1585 KRSPMKKQMSADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARDEAALRSA 1649
              ||..:.:...:.|:....|  :.:|..|.....:.|.:|:.....|.            ||:.
  Rat  1464 --SPEVEPVDVPENEMAGRSH--VMQRVLSTMQFLWVLGQATVDGLTRW------------LRTF 1512

  Fly  1650 QRPHSWGPVGTSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEIDFLEEENI 1714
            .:.|        ..|..::||  |..||.....|.|:.
  Rat  1513 TKDH--------RTMSDVLCA--ERYLLTQELLRGGEV--------------------------- 1540

  Fly  1715 TESEMKMQRRKTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEKEKIGPDLGLASDH 1779
                                       |..:.::.|.||          ||....||
  Rat  1541 ---------------------------HRGVLDQLYVSE----------DEIALSGP-------- 1560

  Fly  1780 DEDDDTIECDLGMRTSTLSEPLDFGRRSQTLLEVKSKDAPTGEFPSTSKGISKERDAATASSSAS 1844
                                             |:::|.|                 :||||
  Rat  1561 ---------------------------------VENRDGP-----------------STASS--- 1572

  Fly  1845 PAPTRDVGDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDFDTNPIIRLLEGFL 1909
                              |||.|:
  Rat  1573 ------------------GLGAEE----------------------------------------- 1578

  Fly  1910 VTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSS 1974
                                                                        |.||.
  Rat  1579 ------------------------------------------------------------PLSSM 1583

  Fly  1975 TPRRVVIAPPNATEHSDPTSTTLNTN-------TTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQH 2032
            |           .:...|.||..||.       |.|..|.....|...|.|..|..:       .
  Rat  1584 T-----------DDTGSPLSTGYNTRSGSEEIITDTGGLQAGTSLHGSQELLANART-------R 1630

  Fly  2033 IRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGTMLSRKSDCGLPEIRIKAPSIERGAHYYHNHH 2097
            :|.|.|:                           :|.|         |::.|.:|
  Rat  1631 MRTASEL---------------------------LLDR---------RLRIPELE---------- 1649

  Fly  2098 SGGGSGSLSKHWSYEQVDSAGEFNLEEENF-AQRDHHIIVEVLISSWYALLANTDLICYIVVFIN 2161
                                     |.|.| ||:..  .:.:|.:.:..:.|:::|:||.::.:|
  Rat  1650 -------------------------EAEQFEAQQGR--TLRLLRAMYQCVAAHSELLCYFIIILN 1687

  Fly  2162 QVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI-WSNY---HQL 2222
            .:|.||..||.||::||||..|::|||:|.||:|.|.:|:.:|:.|.:|||... |::|   .:.
  Rat  1688 HMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYIVLRRY 1752

  Fly  2223 PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLW------------KSGYKDTDNQ 2275
            .|:|..|.:|.|:|....|..|||:.|:.||.||..|...|||            :|..||.:
  Rat  1753 ENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDGVPKDHCRSSEKDQE-- 1815

  Fly  2276 FTKPTASIDERDDSDNLSQPDS----------------------------------RQLNDDAAQ 2306
                   .:|..::...|||::                                  ..|.....:
  Rat  1816 -------AEEESEAKLESQPETGTGHPEEPVLTGTPKDHIQGKGSVRSKDEIQDPPEDLKPQHRR 1873

  Fly  2307 KLSLQVSQASLPGSPEFS-------------------------KTGINQLERTK----------- 2335
            .:|::..:......|:.:                         :.|:...|:.|
  Rat  1874 HISIRFRRRKETQGPKGAAVVEAEHEEGEEGREAAGRKRLRRPREGLKIREKMKAAGRRLQSFCL 1938

  Fly  2336 -----YTSSLYKFFFSLVH-KSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYL 2394
                 :...|.:||..::| |.|.||||||||||.|.|:..|::|||.|||.....:|  :.:.|
  Rat  1939 SLAQSFYQPLRRFFHDILHTKYRAATDVYALMFLADIVDIVVIIFGFWAFGKHSAATD--IASSL 2001

  Fly  2395 AENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSL 2459
            ::::||..||.||||||..:||||||||||.::.|:.|....|:.||:||||::||||||.|...
  Rat  2002 SDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHLWMFFILPAVTERMFRQN 2066

  Fly  2460 APPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWV 2524
            |...::|.:||.|..||:|||:.|||.||||||.||.::.:|:..|:.:..:|||.|||.::|||
  Rat  2067 AVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWV 2131

  Fly  2525 CIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGP 2589
            ..|:|:::.:|:.:|||::||::|:|:|::|..:|..:.|||..:.|..|||.|:|.::..||.|
  Rat  2132 WTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFP 2196

  Fly  2590 LCLFAL-GNAVGTSNVPFHVSLSIRIGPYDPIYTTN-NYDSIFEINPEMYSQMTNAYIKEKQALT 2652
            |...:| .:.||..|.|..|::::::|.|:|::|.: ...||....||.|.:::..:.....|:.
  Rat  2197 LLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPEDYEELSQQFDPYPLAMQ 2261

  Fly  2653 FIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHT-LKARFSYSLTRKAPAKGLKENV 2716
            ||:.|...|:...::.|:|.:||.|:||.|.::.::|.|... :..||:::..|.....|..|..
  Rat  2262 FISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKHELYNGTADITLRFTWNFQRDLAKGGSVEYT 2326

  Fly  2717 GDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGD 2781
            .::|.:.|..:...|..|..:|....|                  :.||||.:.||:|:..|..:
  Rat  2327 NEKHTLELAPNSTARRQLAQLLEGRPD------------------QSVVIPHLFPKYIRAPNGPE 2373

  Fly  2782 AAVVSVLSP-KHYDYRPLVIKMHRDNETNGL--------------WW--EIRDYCNDTFYNETLS 2829
            |..|..|.| :..||..:.|::.|:....|.              ||  |::| |.
  Rat  2374 ANPVKQLQPDEEEDYLGVRIQLRREQVGTGTSGEQAGTKASDFLEWWVIELQD-CQ--------- 2428

  Fly  2830 KFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLP 2894
                :.|.. :.|..|:||..|.:..||...||:|||.:.||:..:|::.|....:..||||:||
  Rat  2429 ----AECNL-LPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSDISHSIMFEELP 2488

  Fly  2895 YVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKE 2943
            .|||:|:||.||:||||..|..|||:|:|||:||||||||:|||||.||
  Rat  2489 CVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Piezo	NP_001303314.1	PIEZO	1226..>1363	CDD:292539	44/136 (32%)
Piezo	NP_001303314.1	Piezo_RRas_bdg	2511..2941	CDD:288978	153/449 (34%)
Piezo1	XP_008770848.1	PIEZO	1223..1445	CDD:292539	76/355 (21%)
Piezo1	XP_008770848.1	Piezo_RRas_bdg	2117..2535	CDD:288978	153/450 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343457
Domainoid	1	1.000	407	1.000	Domainoid score	I681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1062	1.000	Inparanoid score	I236
OMA	1	1.010	-	-		QHG46055
OrthoDB	1	1.010	-	-		D13738at2759
OrthoFinder	1	1.000	-	-		FOG0001637
OrthoInspector	1	1.000	-	-		mtm9141
orthoMCL	1	0.900	-	-		OOG6_102664
Panther	1	1.100	-	-	LDO	PTHR13167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1528
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910