DRSC/TRiP Functional Genomics Resources

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Protein Alignment Piezo and piezo2b

DIOPT Version :10

Sequence 1:NP_001303314.1 Gene:Piezo / 34112 FlyBaseID:FBgn0264953 Length:2973 Species:Drosophila melanogaster
Sequence 2:XP_021323945.2 Gene:piezo2b / 100534973 ZFINID:ZDB-GENE-130530-810 Length:3001 Species:Danio rerio


Alignment Length:3390 Identity:853/3390 - (25%)
Similarity:1407/3390 - (41%) Gaps:835/3390 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVFSYACMVLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLT 65
            |.....|.::.|:::|..|..|.|.|..|:||:|||...:.|..|..:....:|........|..
Zfish     1 MASEVVCGLVFRVLLPVCLAAACLFRFNGLSFIYLLFLLLIPLFPEPSSITMRGQTGYLLKSLCC 65

  Fly    66 LSTLVLLGHITLQILAVSLTL-----PIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVF 125
            .|...|..||..||...||..     ..:|||..|:.:|.|||.|.|.......|...:|::.:|
Zfish    66 CSVTFLFFHIIYQITVHSLLARGRVDSGFNCSVWEKSIRQIGFESVIGADAGNGIRVFLPDIGMF 130

  Fly   126 ATSLGSYLTVKRVASQ-PV-----------------GAEQLEN---------------------- 150
            ..|||.:|..:::..| |.                 ..|:|||                      
Zfish   131 MASLGVWLLCRKLLHQRPTEDMAQDNQQFLSEEKEEENEKLENEEDENDNNDDDDDEMLFDEDFD 195

  Fly   151 ----GEVVDGQAENAQTSSQPSAADANGGDVQQATVTTPLQQQQQQLRKRVSMISQHIHFEGLVK 211
                .|..||:|...:...:....:.   :||::|....|:.......|...:|...|...|.|.
Zfish   196 AEDEAEEEDGEAGRLEEEEEEEEEEE---EVQESTKMKILRAVGGVAAKLKEIIGNLITTAGQVV 257

  Fly   212 ISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQRGFALLLRCVMVVLVLHSLS-- 274
            ::.:     |....|..||:....||.:||...|:|:.|:|..:   ||..|:.|::.:.|..  
Zfish   258 VTIM-----LGMTGVTLPSLSSAVYFFVFLGLCTWWSLCKTFDK---LLFSCLCVLMAIFSAGHL 314

  Fly   275 IVSY--QTPWMQSHLNHTTLTARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFA 337
            ||.|  |..::|..::.|.....:.|:..:|.:.||...::.: .:.|....::||..:...|:.
Zfish   315 IVLYINQFQFLQEAISPTDGYTSVFGISSIIYTDCSSTWKLAV-RSGLKWHHFVNPIMILVLYYT 378

  Fly   338 LALTTK-----------------------------HL-IKPRLV----RQSTRKAR--------- 359
            ||...:                             |. |:.||:    .|.|.:..         
Zfish   379 LATLIRLWLQDPMMMEDSEDGEVIEGNEAMENNVHHTSIRKRLLWWKAHQKTEERNLISTQDGYS 443

  Fly   360 -----------------TPQPLESGS-----------SVAPSV---------TQRGNDMQLESME 387
                             :..|:|:|.           .|..||         |....|.|||..|
Zfish   444 TSEVLVVTSNGTSFDYVSAVPIENGPVSLDIYSTPQYKVDQSVEYDEKTDENTNEVLDSQLEEEE 508

  Fly   388 QRSEQENTTTSILDQISYG-----FVSVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANV 447
            :::::|...    ::...|     .|.|..||.:.|||...|.||||||.|.||||||.|:.:..
Zfish   509 EKTDEEEEA----EEEEQGGPPAALVKVFKFIMKQSYICALIAMMAWSITYVSWLTFVFLIWSCT 569

  Fly   448 LWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEEL-PTSVPTAGINLQQIGFERPIENQ 511
            |||:.::||..|.:|||:|.|...||:.|||:..    |:| |.|           ||...:|  
Zfish   570 LWMVRDRRKYAMLTSPFMVAYGNFLLVLQYIWCF----EKLKPVS-----------GFFVKME-- 617

  Fly   512 MRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSK 576
             .|...|..|....|.||:..||...|:::|:.:.              :|.|...:::.||..:
Zfish   618 -VPFTELSTKVLCQLSFWLLLRQTLMERQERKEEE--------------AALSDIKVDEQKKVEE 667

  Fly   577 ----------FLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQS 631
                      .::..|.::..|||:.||::...:.|..:..|: |..::|.||.:.|..:.::|.
Zfish   668 KSEEEVDENDLMQVLGKLVMALLVKYWIYVCGGMFFFVSFEGD-MATYKIIYMMMLLSCVALYQV 731

  Fly   632 SSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFL 696
            ..:.|.:|:..||:.::.|.|.:||||||.||:.....|:....:...:.|||||:::...:||.
Zfish   732 HYEYWRRILKYFWMSVVVYTMLVLILIYTSQFEDGIPTWTRMTGLDKDVLKDIGLEKFSLSNLFT 796

  Fly   697 HLVSPTIIVILTVIQVHYFHKRF------------------------------------------ 719
            .:..||..:::.::.:||||..|                                          
Zfish   797 RIFIPTSFLLVCILHLHYFHDHFLELTDLKAVVSKQESTIYSYAKVSGRIYLIVDSIKQKISSSQ 861

  Fly   720 --------------IASLQQQPLAGGSAQQKP-TETTALEPAPSKRRGSAGSLRKSQGPSAEAA- 768
                          |.|...:||.....:::. .|...::....:::..:.|:..:|..|.|.. 
Zfish   862 SKLAHPDGSLADLTIVSSSPEPLLKDEKEKESLNEVLVVDCVGEEKKKDSLSIYSAQMSSQEDVH 926

  Fly   769 -PGATTDFETS-------------VRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYI 819
             ..|.||.|..             |.|.:.:.|.|.   .|| |...|...|..||:||:|.|..
Zfish   927 QSSAATDPELPSEQSSEMKNKWHLVVDRLTVLFLKF---LEY-FHKLKLFVWWLLEMHIIKIVAT 987

  Fly   820 AAFVCSVSEVCVLHIIFV---GFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQ 881
            ...:.||.||.:|:.:|:   .|    |...|..:|:.|.:.:....||::.|:.||::.::.:.
Zfish   988 YIILLSVKEVSLLNFVFLISWAF----ALPYKQFRVLSSSVCTVWTCVIIVCKLFYQLKTINPAN 1048

  Fly   882 HNVVC----------SDNRTA-------NNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAV 929
            ::..|          .|.:|:       :.|.|:||.|.|.  |.::..||..::.:.::.....
Zfish  1049 YSSDCIMPNYTETEKKDMKTSLLYRDPVDPANWVGLRKFDH--GIILPNLRNNLLMLALLAFEVT 1111

  Fly   930 ISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTIT 994
            |...|...|:: ..|:.||::.:|.:|.|...:..::...||.:|:.|||||:|:..:..::.:.
Zfish  1112 IYRHQEFFRLR-NKLSPPPSRTIFHDITRQHLDNGIIECAKYFINYFFYKFGLEVCFLLAINVMG 1175

  Fly   995 YRQDIVAVVYALWLVVLLLLRRSQC-AKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPW--DE 1056
            .|.|..::|:.|.|.|::..||.:. |:||..:..|.|..|..||.:.:|:||::|..:||  ..
Zfish  1176 QRMDFYSMVHGLALAVVMFRRRRKAIAEIWPKYCCFLACMITFQYFICIGIPPAACADYPWRFPN 1240

  Fly  1057 GPFGEGIQRWAMLPGALHFNHVPKLIF---DFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSV 1118
            ......:.:|..||   .|:..|..:|   ||::|:..:.|:.:|..|.:.|..  ...|.|..:
Zfish  1241 SSMTSNVIKWLYLP---DFHTPPSSMFLGYDFMLLLCASLQRQVFDEENKAAVR--LMAGDNVEI 1300

  Fly  1119 IADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGA 1183
            ..|: ........||..||. :.|:|.|:||..:....:||.|.::|:.||....:..:|||:..
Zfish  1301 CRDL-DAASFSVHNPVPDFI-HCRSYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVAC 1363

  Fly  1184 FIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITC 1248
            |.||..|....|:||..|:..|.:|:|:||..|.:|..|.:..|.::..|.|:.|||:.:|.:.|
Zfish  1364 FYFLLFGGQLLLKPIKEILRYWDFLIAYNVFVITMKNVFAILACGYINSLVKNSCWLIQLLSLAC 1428

  Fly  1249 TSNVLTEQIMLP-EEAELALKPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKA 1312
            |......:..|| .:.||       ||  .:..::||:|||.|::.|.|:|.|:||.|:|.|.:|
Zfish  1429 TIKDYQPKTDLPGVDCEL-------PK--DEAGIIWDSICFTFLLLQRRVFMSYYFLHVIADIRA 1484

  Fly  1313 NNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDK-----QTHFDG 1372
            ..|||||||::.::...|.:..|.:.||:.:.::||:|:||:..|||..|..:|     |...||
Zfish  1485 GQILASRGAELFQASIVKAVRARLEEEKKSMEQLKRQMDRIKTRQQKFKRGKEKMLSIAQESGDG 1549

  Fly  1373 RR----------TPSEHAMSDV------APLVHNSSFTSCQGSGYL----TPDEHSSATSGTSSP 1417
            .:          ...|...:.|      .|.|.::|... .|..||    :.:|..........|
Zfish  1550 EKLIPPVDNEEEEDEEKKKNKVQKKQWWRPWVDHASMVR-SGDYYLFETDSEEEEEEEEKKDEEP 1613

  Fly  1418 ARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYVDVQSVSEEETTVAMPKKDLSCQSK 1482
            .:.|...      .::....:|::..|...:.....|..|:...:.....|.:|..|..|..:.|
Zfish  1614 PKRSAFQ------RAIRKFASALVALPRSIIKLPKTILQYLIRAAKFVYHTWIAESKAALKERGK 1672

  Fly  1483 ECVF--------------------------KSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLA 1521
            ...|                          :|.|..|     ||....::...|           
Zfish  1673 GKRFWKRYGRRHKKEKKEEHVAIEIGEDERQSSEEEK-----TDGPDNIIKRVF----------- 1721

  Fly  1522 PPELSPPVGMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSIKR 1586
                           .:..:..|:..:...|:  |....::.||:         :..:..:.|:|
Zfish  1722 ---------------NIIKFTWALFLTTVESI--TKWLNSVCREY---------IDISTVLRIER 1760

  Fly  1587 SPMKKQMSADKEEVVTMRHKSLHRRHQSM----GNASYSLDEASQSQRKRLSSNLSGARDEAALR 1647
            ..:.:::   |:..|..| :|:|..:|..    |:....||..|:             .|.|:.|
Zfish  1761 CMLTREV---KKGNVPSR-ESIHVYYQKQMKLNGSRESGLDRISE-------------EDSASNR 1808

  Fly  1648 SAQR--PHSWGPVGTSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEIDFLE 1710
            ..:|  .||   :.:.:..:|:..|:.|..:|                   |......|::|.:.
Zfish  1809 ERRRRAQHS---LDSFASRDSISSAYTEATML-------------------FSRQSTLDDLDDMP 1851

  Fly  1711 EENITESEMKMQRRKTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILL--------------- 1760
            :.....||....:.:.:|.:  |::::             :::.||.::.               
Zfish  1852 QNIPKTSERARPKLRKMYGL--DMSNS-------------SADSGSSVISSEATQCVTLFSRQGT 1901

  Fly  1761 -----KLDDEKEKIGPDLGLASDHDEDDDTIECDLGMRTSTLSEPLDFGRRSQTLL--------E 1812
                 :.:||:|::        :|.:  .|.|.:|..:.....|.....:..|.:|        |
Zfish  1902 NDTIDEAEDEREQL--------EHKQ--KTEEAELRDKPEEEQEVETSDQGKQEVLPVSHLVTQE 1956

  Fly  1813 VKS-----KDAPTGEFPSTSK---GISKERD-------AATASSSASPAPTRDVGD---LPVIPP 1859
            ||.     .|..|||.....:   .:.||.:       .|............:||:   ..::.|
Zfish  1957 VKEDVLPVSDQLTGEVTEEVEEEVEVVKEMEEEVEKEIGAKVEKEVEAEKEEEVGEEVQWDLVDP 2021

  Fly  1860 P------STGLGREQTSKETSDSKSKMEVDSGEVTAKDSD----EDFDTNPIIRLLEGFLVTLTI 1914
            .      |.|.|.||..::..:......|.||.:...|:|    .|.|..|              
Zfish  2022 EEAEECVSDGEGGEQMQQDEGEWSGVENVVSGPLFTPDTDAPNTSDADVPP-------------- 2072

  Fly  1915 RLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSSTPRRV 1979
                                 :..::.|.:||.:|              ||:|:     |..|.:
Zfish  2073 ---------------------SYSKAVSFDRLSVS--------------SDDSD-----SDKRLM 2097

  Fly  1980 VIAPPNATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRAAEEIIELPV 2044
            ::.|.:.::..||...::.|:.|                                 |.|::    
Zfish  2098 LMTPDSKSDLDDPLLPSMTTDMT---------------------------------ASELL---- 2125

  Fly  2045 DTVDGVAHRKQSINSSPPAKGTMLSRKSDCGLPEIRIKAPSIERGAHYYHNHHSGGGSGSLSKHW 2109
                                                                        |:|.:
Zfish  2126 ------------------------------------------------------------LNKMF 2130

  Fly  2110 SYEQVDSAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLP 2174
            ..|.:||:..|        .:...:.:::..:.:..|:|:::::||:|:.:|.:::||:.:|.||
Zfish  2131 YDEMLDSSDRF--------YKSQPLGLQLCYALYNLLVAHSEMVCYLVIILNHMISASMATLVLP 2187

  Fly  2175 IMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPN--QPLTPAKIFGVEN 2237
            |::|||..||:|||:|.||:|.|.||:..::||..|||.....|.:...|  :|..|..|.|.|.
Zfish  2188 ILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFSFFPFNQNLEVNKGKPYHPPNILGTEK 2252

  Fly  2238 KAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKP-TASIDE-------RDDSDNLSQ 2294
            |..|..|||:.||.||.||.:||..|||.........:...| ..|:|:       ..|.|..|.
Zfish  2253 KDGYVHYDLVQLLALFFHRSILKCHGLWDEDDPKVPRKDECPRQESVDDGKLSVVMSPDEDRKSS 2317

  Fly  2295 P-------------DSRQLN---------------DDAAQKLSLQVSQASLPGS----------- 2320
            |             ||.|::               ..:....|.:.|..|..||           
Zfish  2318 PAYSLKSMNLGMSVDSSQVHIQMRYPEQRPYLRRQSTSGSHFSHRSSARSKRGSTSTRHSTHGEN 2382

  Fly  2321 -------PEFS--------------KTGINQLER-TKYTSSLYKFFFSLVHKSRLA-TDVYALMF 2362
                   |:.|              |..:..|:| .::...:.:||::|||....| ||||.|||
Zfish  2383 STTESEVPQKSRKEMIMEKIREQLIKAKVYLLKRLVEFYQPIRQFFYNLVHPEYSAVTDVYVLMF 2447

  Fly  2363 LCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALV 2427
            |.|.|:|.:::|||.|||..|..:|  :.:.|:|::||.|||:|:|:||..:|:||||||||.:|
Zfish  2448 LADTVDFIIIVFGFWAFGKHQGGAD--ITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVV 2510

  Fly  2428 NKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNF 2492
            .|:||....|.|||.||||::|.:|||.|:......::|.:||.|..||:|||:.|||.||||||
Zfish  2511 GKVIFQVILVFGIHFWMFFILPGITERRFSQNTIAQLWYFVKCIYFGLSAYQIRCGYPTRILGNF 2575

  Fly  2493 FTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETD 2557
            .||.::..|:..|:.:..||||.|||.::|||..|:|:::..|:.:|||:::|::::|.|:||..
Zfish  2576 LTKSYNYANLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKR 2640

  Fly  2558 FPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAV-GTSNVPFHVSLSIRIGPYDPIY 2621
            :|..|.|||..:.|..|||.||:|::..:|.||...:|..:| |..|.|..||:|:.:|...||:
Zfish  2641 YPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLEVSVSLTLGGLQPIF 2705

  Fly  2622 TTN-NYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRL 2685
            |.: ..:.|..:....:.:.|:.|.....|:.|:..|...|:....|.|:|.|||.|:||.::.|
Zfish  2706 TMSAQQNHIKSVTGAEFKKFTDHYKSNANAIMFLESYFPEDLTIAHLEGSSNSLWTISPPSKENL 2770

  Fly  2686 ---LNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPI 2747
               |||.|....|  .|::|:.|........|....::.|.||                      
Zfish  2771 KNMLNDTREPFPL--TFTWSIQRNLSLGAKAETAMGKYFIELD---------------------- 2811

  Fly  2748 YSNGTTNGTTPEV---EEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHY---DYRPLVIKMHRDN 2806
              |.|..|.|.::   .:.|.|..:.|::|:..:..:|..:..|    |   :|..:.:.:::.|
Zfish  2812 --NETRKGLTDQLGNSSQRVTIKKIFPRYIRAPSDSNAKPIDQL----YNDGEYMDITLFLNKKN 2870

  Fly  2807 ETNGL--WWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTF 2869
            .:.|:  ||.:         |:|.|........||:.:|..:|:..|.:..||...||:|||.:.
Zfish  2871 SSEGVQEWWIV---------NQTDSGPLPGLNGSGLQIYIISDQVSPPSLGFLAGYGIMGLYMSV 2926

  Fly  2870 VLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPET 2934
            ||:..:|::.|..|.:..||||:||.|||:|:||.||:||||..|..|||||:|||:||||||||
Zfish  2927 VLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPET 2991

  Fly  2935 LIKWTRPKEE 2944
            :|||||.|.|
Zfish  2992 MIKWTREKSE 3001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PiezoNP_001303314.1 PIEZO 1226..>1386 CDD:464941 57/181 (31%)
Piezo_RRas_bdg 2511..2941 CDD:463481 152/442 (34%)
piezo2bXP_021323945.2 None

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