DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Piezo and LOC100498074

DIOPT Version :9

Sequence 1:	NP_001303314.1	Gene:	Piezo / 34112	FlyBaseID:	FBgn0264953	Length:	2973	Species:	Drosophila melanogaster
Sequence 2:	XP_031750362.1	Gene:	LOC100498074 / 100498074	-ID:	-	Length:	2614	Species:	Xenopus tropicalis

Alignment Length:	3158	Identity:	800/3158 - (25%)
Similarity:	1343/3158 - (42%)	Gaps:	803/3158 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PFVPLATRRNFKGSVTAFFIILLTLSTLVLLGHITLQILAVSLTLPIYNCSFSERLLRHIGFVSF 106
            |.||..|....||...:|...:...|.|:||.....|| |.....|..|  ..|.:|.|.|.:..
Frog     4 PLVPNPTYITMKGRTGSFLRSIYYCSFLMLLLQSCCQI-AFRYIPPRGN--LWETVLGHFGILRL 65

  Fly   107 IDLQPFAIIEWLVPEVLVFATSLGSYLTVKRVASQ--PVGAEQLENGEVVDGQAENAQTSSQPSA 169
            ..:..:.|:..|..::.:|   ...|. ::|...:  .|||.:|.:  ..:.|.|..::.|: |.
Frog    66 SQVDAWNIVRLLASDIGMF---FSGYF-IRRACKKLVKVGAPKLSS--QTNSQEEEEESPSE-SE 123

  Fly   170 ADANGGDVQQATVTTPLQQQQQQLRKRVSMISQHIHFEGLVKISPLF----------------CL 218
            .:.:.|:...:|......:.....|.::           :.||:|:.                .:
Frog   124 TEESEGETDFSTEENLADKASNDFRAKL-----------IEKITPIISAVKALVEALFNTAGKVV 177

  Fly   219 ATLF--FAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQR-GFALLLRCVMVVLVL--HSLSIVSY 278
            .||.  |:.|..||:....||..||...::||:..::.. .|:.|  |||..:..  |..::..|
Frog   178 VTLLLGFSGVTLPSITSAVYFFTFLWLCSWWASNHSVSLVVFSSL--CVMAAIFSAGHLTALYLY 240

  Fly   279 QTPWMQSHLNHTTLTARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTK 343
            |.|..|..:....|.|||.|:..:|.:..:....:.|::: |....:|||..|...|:.|.:...
Frog   241 QLPVFQELIPPQDLYARLFGMTAIIRTNSTQSWIIHLHHD-LQWPVFLNPLILLLMYYTLVMLLD 304

  Fly   344 HLIKPRLV--RQSTRK------ARTPQPLESGSSVAPS---------VTQRG-NDMQL---ESME 387
            ...:..:|  .|.|.|      ::..|.|:  ..:.||         ::..| .|:.|   |.::
Frog   305 QWNQIPVVYCEQETEKDMAASHSKEHQQLD--GMLWPSHAEMLQTEYLSHNGWQDLPLLKCEHLQ 367

  Fly   388 QRSE-------QENTTTSILDQISY---------------GFVSVGGFIYQNSYIFTNILMMAWS 430
            .:::       ||..||   |::|.               |.|.:|.|:.:.||:...|:||.||
Frog   368 GQTDFSVPIYSQEVDTT---DEVSETEETKEVPEKEAKPGGLVVLGEFLMRQSYVSALIVMMIWS 429

  Fly   431 IVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTA 495
            |.|:|||||||||.:.|:||:.::|:..|.|:||:.|||..|:|..:..|:.|:.|||...:|.|
Frog   430 ITYNSWLTFVLLLWSCVIWMMRDRRRYAMLSAPFLALYANILVIQNFFVGLSLSQEELFPGIPNA 494

  Fly   496 GINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVG 560
            .:    |.|:  ::....||..|:||..:...||:..||..||:..:.::..|.:.:.....|..
Frog   495 IL----IDFD--LKPYTLPCTHLMVKIMYAFTFWILLRQNLKERHQKLKEEELKEVLVDETETEQ 553

  Fly   561 SAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFF 625
            |            :|.|:...|.:|:.:||:.||:....:.|:.:..|: :..::|.|:.||||.
Frog   554 S------------SSTFMDMLGSLIRAMLVKYWIYFCGAMFFVISFRGK-VVVYKILYIVLFLFC 605

  Fly   626 LLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQ 690
            :.:::...:.|.:|:..:|:.::.|:|.:||.||.|||.....::...|.:|....||:||::|.
Frog   606 VTLYKIHYEWWRRILKYYWIAVVSYSMLVLITIYVYQFKTISGFFLQILGMSEEGLKDLGLEQYS 670

  Fly   691 TKDLFLHLVSPTIIVILTVIQVHYFHKRF--IASLQQQPL-AGGSAQQKPTETTALEPAPSKRRG 752
            |.:||..::.|::.::..::|::|||..|  :..|...|: .||.|..|           .|..|
Frog   671 TVELFTGILMPSLFLLACILQLYYFHDDFLKLTDLNNIPINQGGVADSK-----------KKMEG 724

  Fly   753 SA-----------GSLRKSQGPSAEAAPGATT----DFETSVRDLVRIS--------------FR 788
            ..           |:|....|.:.|.:....|    |..|....:||.|              ..
Frog   725 RVLLLANVIKEIFGNLHNKLGKNNENSVSQNTLDKIDNITMDEHVVRDSQEFADGKANRWLLVID 789

  Fly   789 KIKNKSEYIFKNFKD---VFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIF-------VGFCVLG 843
            |:.:...::.....|   :.||.|||||:|.|.......::.||.:::.:|       |.|..|
Frog   790 KVMSVLLFLLGFIHDTEVLVWRLLELHIIKIVSSIIIWITLQEVSLMNCLFYMPWVFAVPFSFL- 853

  Fly   844 ATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSDNRTANN-------------- 894
                   :...|.:.:....::|:.||:||::::...:::..|:::...|.
Frog   854 -------RPYASNISTVWSCIMVIFKMMYQLKFVKPLEYSSNCTESLYRNGTLYSPISEELQQKS 911

  Fly   895 ---------AEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTK 950
                     |.|.|..:  |.|..::..::.::..:|::.:.:.:...||..||. ..|..|.|.
Frog   912 DLYVAPVDPALWCGGLR--KCTDSVLPCIQNHLTILVLLAIESTVYRHQLYYRVH-NQLRTPITG 973

  Fly   951 LLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLR 1015
            .:|.||.|...::.|:..:||.:|:.|||||:||..:..|:.|..|.|..||::|.|::.||.||
Frog   974 SIFDNITRRHLDEGLLNCIKYFVNYFFYKFGLEICFVISVNVIGQRMDFYAVLHACWMLYLLYLR 1038

  Fly  1016 RSQ-CAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPF--GEGIQRWAMLPGALHFNH 1077
            |.: .|::|..:..|.|..:..||::.:|:||:.|..:||....:  ...:.:|..||   .|..
Frog  1039 RRKTIAEVWPNYCCFLATIMTLQYLLCIGVPPAFCSDYPWRTSSWSPSSNLIKWFYLP---DFAK 1100

  Fly  1078 VPK---LIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVI-----ADIAQLGRVPFDNPT 1134
            .|.   ||:||::|::.:.|..:|  |....:......|.|..:.     ||::|...||  |..
Frog  1101 SPDPGFLIYDFMLLLLASLQWQVF--EDENLACFRLLAGDNIEISRDLDPADLSQYSPVP--NFI 1161

  Fly  1135 HDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIH 1199
            |  |   |:|.|:.|..|....:||.|.::|:.||...::|.:||||..|.|:..|....|:|:.
Frog  1162 H--C---RSYLDMAKVVVFSFHFWFVLCLIFITGTTRINILCMGYLIACFHFMLFGGTLLLKPVR 1221

  Fly  1200 TIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAE 1264
            .::..|.:|:|:....|..|....:..|:::.:|.|:.|||:....:.||  :...::.:..:.:
Frog  1222 HVLRLWDYLIAYTALVIATKNLLSIGACVYLHKLMKNNCWLIQTFSMFCT--IKGYELTIASDVD 1284

  Fly  1265 LALKPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRH 1329
            ..|...|..       ::||.|||.|::.|.|:|.|:||.:::.|.||:.:||||||::.|....
Frog  1285 CELPENEAG-------IVWDAICFTFLLIQRRVFTSYYFLYVVADVKASKLLASRGAELFEEKVK 1342

  Fly  1330 KQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAMSDVAPLVHNSSFT 1394
            |.:|.|.:.||:....:|::||:|::.|:                          ||.:..
Frog  1343 KMVAARLEEEKKCAQSMKKQMEQIKSKQK--------------------------APKIDK---- 1377

  Fly  1395 SCQGSGYLTPDEHSSATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYVD 1459
                                             |:.|:|..|
Frog  1378 ---------------------------------GTDENVGCA----------------------- 1386

  Fly  1460 VQSVSEEETTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLAPPE 1524
                 .||.:...|:.|...:.|:
Frog  1387 -----VEENSEPSPRDDSDKKDKD----------------------------------------- 1405

  Fly  1525 LSPPVGMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSIKRSPM 1589
                 |.:....|...: |.|..|.:.|:..|:                   |.:|
Frog  1406 -----GKKKWWQPWVTH-TTMVRSGSYSLFDTD-------------------SEDE--------- 1436

  Fly  1590 KKQMSADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARDEAALRSAQRPHS 1654
            :::|..:|.|....:.||..:       .:|...........:|..|     ||..:|...|..
Frog  1437 EEEMREEKREEEPPKRKSAFQ-------LAYEAWTVGSKSALKLRQN-----DENTMREQIRKE- 1488

  Fly  1655 WGPVGTSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEIDFLEEENITESEM 1719
                     ||.                ::|        :.|.|        :.|||...||||
Frog  1489 ---------MEK----------------KSG--------EGKLE--------ELLEETEETESE- 1511

  Fly  1720 KMQRRKTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEKEKIGPDLGLASDHDEDDD 1784
            :..:.:....:.:.:|.|.:                |.|.::            .||      ||
Frog  1512 EANKERPDNAIQRIVNIARF----------------SWIFIQ------------ALA------DD 1542

  Fly  1785 TIE-----CD--------LGMRTSTLSEPLDFGRRSQTLLEVKSKDAPTGEFPSTSKGISKERDA 1836
            |||     |.        |.|....|...||           |.|:|..|......|  :|:
Frog  1543 TIETLNAFCKSSVDIASVLRMERCMLQRNLD-----------KGKEASQGSIAEYYK--AKQ--- 1591

  Fly  1837 ATASSSASPAPTRDVGDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDFDTNPI 1901
                                       |.|.||                 :|::|::|.
Frog  1592 ---------------------------LSRTQT-----------------LTSEDNEES------ 1606

  Fly  1902 IRLLEGFLVTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDE 1966
                                         |||:.|..:...|.:           ||  ::||.:
Frog  1607 -----------------------------AGEETTQNKKLELCK-----------FL--SMESQQ 1629

  Fly  1967 SEPPASSSTPRRVVIAPPNATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQ 2031
            |:....||.|                        |....||..|.|.|             :::|
Frog  1630 SQDSFLSSCP------------------------TEDMVLSFDESLGP-------------EENQ 1657

  Fly  2032 HIRAAEEIIELPVDTVDGV-----------------------AHRKQSINSSPPAKGTMLSRKS- 2072
            .:|..:.::.....::|.:                       .|.|..|   ||:..|::::..
Frog  1658 RVRGPKRMLAFDSTSLDSLDSRPEGHGEQKEDEEYDGEDETSEHTKTDI---PPSYSTVIAKGDL 1719

  Fly  2073 DCGLPEIRIKAPSIERGAHYYHNHHSGGGSGSLSKHWSYEQVDSAGEFNL------EEENFAQRD 2131
            :...||      .:.:|...|....:           ...|:.:|.|..|      ||...::|.
Frog  1720 ESSEPE------DVPQGEGKYFRPLA-----------EVPQLLTASELLLNKMYYDEELEESERF 1767

  Fly  2132 HHII---VEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFW 2193
            :.::   :.|.::.:..:::.::::||.|:.:|..|:||::||.|||::|||..||:|||||.||
Frog  1768 YQMLPRPLRVCLALYNTIVSKSEMLCYFVIILNHTVSASILSLILPILIFLWAMLSVPRPTKRFW 1832

  Fly  2194 VTLIAYTQAIVLIKCIFQFKLI-WSN--YHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFL 2254
            :..|.|||..|:||..|||... |::  |..: .::|.....|.|:|.|..|.::|||.||.|||
Frog  1833 MLAIIYTQITVVIKYSFQFGFFPWTSTVYRSMNADKPFHLPNIIGIEKKDGYVLFDLIQLLALFL 1897

  Fly  2255 HRYLLKSQGLW----------------KSGYK-----DTD-NQFTKPTASIDERDDSDNLSQPDS 2297
            ||.:||..|||                |.|.|     |.| |....|......::.|.|:.:  .
Frog  1898 HRSILKCHGLWDHKEVSLPESKRKRKSKKGKKRGSKGDEDPNSGMVPWHLFKHQNPSKNVFR--K 1960

  Fly  2298 RQLNDDAAQKLSLQVSQAS--------------LPGSPEFSKTGINQLERT-KYTSSLY----KF 2343
            |:::..||::...|..:|.              .|...:..:..|...:.| |....:|    :|
Frog  1961 RKVSQMAAEEGKTQKKEAKRKWKWFRWNHKKKRQPIRQKIKQQWIKVKKITMKIALQIYLPIRQF 2025

  Fly  2344 FFSLVH-KSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIML 2407
            |:.::| :.....||||:|||.|.:||.:::||:.|||.....:|  :...|:|::||..||:||
Frog  2026 FYDIIHPEYSPVCDVYAIMFLVDAINFIIVIFGYWAFGKHSAAAD--ITESLSEDQVPEAFLVML 2088

  Fly  2408 LVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFY 2472
            |:||..:::|||:||||.:..|.:|....|.|||.||||::|.||||.||:...|.::|.:||.|
Frog  2089 LLQFGTMIVDRAIYLRKTMFGKCVFQVVLVFGIHFWMFFILPGVTERRFNTNQVPQLWYFVKCLY 2153

  Fly  2473 MLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLK 2537
            ..||:||||.|||.|:||||.||.::.:|:..|:.:..:|||.|:|.::||:..|:|:::..|:.
Frog  2154 FGLSAYQIKCGYPNRVLGNFLTKSYNFINLFLFQGFRMVPFLTEMRAVMDWIWTDTTLSLSSWIC 2218

  Fly  2538 MEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAV-GT 2601
            :|||::||::::|.|:||..:|....|||..:.|..|||.|:..::..:|.||...:|..:| |.
Frog  2219 VEDIYANIFIMKCWRESEKKYPEPPGQKKKKIVKYGMGGVIIFALICIVWFPLLFMSLVKSVAGV 2283

  Fly  2602 SNVPFHVSLSIRIGPYDPIYTTN-NYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAV 2665
            :|.|..||:.|.|..|:|::|.: ...::...:...|:::|..|.....|:.||..|...|:...
Frog  2284 TNQPLDVSIKISISGYEPLFTMSAQQQNLVPFSSVAYNELTYRYALHPSAMQFIVNYMPEDIVTA 2348

  Fly  2666 RLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEG 2730
            ::..|:..||:|:|..|:.::.:|.|:..:.....:||.|.|......|..| :|.:..::: |.
Frog  2349 KIKSNASLLWSISPASREAMIEELSNSTRIYFDIHWSLLRNASIVKSAETSG-KHTVCYEDA-ET 2411

  Fly  2731 RAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAA-----VVSVLSP 2790
            |..::.||                  ..|..|.|::..::||..:. |:|..|     :::..|.
Frog  2412 RDQIVQML------------------RGERSEPVMLRNILPKHFRA-NAGSEAKIAHRLITAHSE 2457

  Fly  2791 KHYD------YRPLVIKMHR---DNETNGL--WWEIRDY---CNDTFYNETLSKFAYSNCTSGIV 2841
            |..|      :|.|.:|:..   ::.:|.:  ||.|:::   |            |.:.|:..|.
Frog  2458 KPEDVQKYAFFRNLTLKLETASLNSSSNQMTEWWLIQEWAPAC------------APAGCSRTIE 2510

  Fly  2842 MYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDI 2906
            :.|:|||..|.:..||...||:|||.:.||:..:|::.|..|.:|.||||:||.|||:|:||.||
Frog  2511 LITYNDKASPQSLGFLAGYGIVGLYMSVVLVIGKFIREFFNGISRSIMFEELPNVDRILKLCTDI 2575

  Fly  2907 YLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEE 2944
            :||||..:..|||.|||||:||||||||:|||||.|.|
Frog  2576 FLVRETGDLDLEEQLFAKLIFLYRSPETMIKWTREKHE 2613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Piezo	NP_001303314.1	PIEZO	1226..>1363	CDD:292539	42/136 (31%)
Piezo	NP_001303314.1	Piezo_RRas_bdg	2511..2941	CDD:288978	148/450 (33%)
LOC100498074	XP_031750362.1	PIEZO	1247..1477	CDD:406366	70/416 (17%)
LOC100498074	XP_031750362.1	Piezo_RRas_bdg	2191..2610	CDD:403405	148/451 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I541
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1074	1.000	Inparanoid score	I247
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13738at2759
OrthoFinder	1	1.000	-	-		FOG0001637
OrthoInspector	1	1.000	-	-		mtm9559
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1528
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060