Protein Alignment Piezo and piezo2

DIOPT Version :9

• Sequence 1: NP_001303314.1
• Gene: Piezo / 34112
• FlyBaseID: FBgn0264953
• Length: 2973
• Species: Drosophila melanogaster
• Sequence 2: XP_012820813.2
• Gene: piezo2 / 100492729
• XenbaseID: XB-GENE-1005347
• Length: 2822
• Species: Xenopus tropicalis
• Alignment Length: 3270
• Identity: 845/3270 - (25%)
• Similarity: 1369/3270 - (41%)
• Gaps: 774/3270 - (23%)

  Fly     1 MVFSYACMVLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLT 65
            |.....|.::.|.::|..||:|.:.|..|||||||:...:.|.....|:...:|........|..
 Frog     1 MASEVVCGLIFRFLLPLCLVVACMFRYNGISFVYLIYLLLIPLFSEPTKITMQGHTGRLLKSLCV 65

  Fly    66 LSTLVLLGHITLQILAVSLTL-----PIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVF 125
            .|...||.||..||...||..     |.:|||..|:.:|.|||.|.........|....|::.:|
 Frog    66 SSLSFLLLHIIFQITVYSLEARKHIEPHFNCSTWEKAIRQIGFESVKGADAGNGIRVFAPDIGMF 130

  Fly   126 ATSLGSYLTVKRVASQPVGAE------QLENGEVV-DGQAENAQTSSQPSAADANGGDVQQATVT 183
            ..||.:.|..:::..:.|..|      |..|.|:. :|:.:..:........|....:::.|..:
 Frog   131 IASLATLLVCRKLVQKTVTEEDAQYNPQFVNEEMAEEGKVDLDEALMYEEDFDGEEDEIEAAEES 195

  Fly   184 TPLQQQQQQLRKRVSMISQHIHFEG--LVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTY 246
            |.|    :.||:..|..|....|.|  :.....:.....|....::.||:....||.:||...|:
 Frog   196 TKL----KILRRIASFASVLKEFIGNIITTAGKVVITILLGLTGMMLPSLTSAVYFFVFLGLCTW 256

  Fly   247 WATCQTLQRGFALLLRCVMVVLVL----HSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLIESYC 307
            |:.|:...   .|:..|:.|::.:    |.:.:..||..:....:......|||.|:..|:::.|
 Frog   257 WSCCRVFD---PLIFSCLCVLMAIFSAGHLIGLYLYQLQFFHEIIPPNDFYARLFGVTSLVQTDC 318

  Fly   308 SPDIRVFLYNNKLSLDSYLNPFALFFAYFALA-LTTKHLIKPRLVRQSTRKARTPQ--------- 362
            ....| |..||.|..:.|.||..|...|:.|| |....|.:|..|.:...:..:|.
 Frog   319 CNTWR-FFANNSLPWNQYTNPVMLLVLYYTLATLIRLWLQEPINVEEEKEEDCSPAALTAERRRS 382

  Fly   363 ----------------------------------------------PLESGSSVAP--SVTQRGN 379
                                                          |:|:|.:...  |..|...
 Frog   383 LWYSRHYTTDERQLLSMTQDDYKPSDVLLVTVNGTPVDYCSLNSSLPIENGPTKIDMYSTPQYKW 447

  Fly   380 DMQLESMEQRSEQ--------------ENTTTSILDQISYGFVSVGGFIYQNSYIFTNILMMAWS 430
            |.:.|:.|::.|:              |||...::       |....||.:.|||...|.|||||
 Frog   448 DHEDETSEKKEEEEQEEEPNEEVAEEKENTKVHVM-------VVAFQFIMKQSYICALISMMAWS 505

  Fly   431 IVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTA 495
            |.||||||||||:.:..|||:.|:||..|.||||:|:|...||..|||:.:.|.::|||
 Frog   506 ITYHSWLTFVLLIWSCALWMVRNRRKYAMLSSPFMVMYGNLLLTLQYIWSIALQSDELP------ 564

  Fly   496 GINLQQIGF---ERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQI 557
                :.:|.   ::|.|        |:.|..|.:.||:..||...|::..::..     :|..:|
 Frog   565 ----EVMGLLERKKPEE--------LVSKIIFTVTFWLLLRQHLTEQKALKQKE-----LALSEI 612

  Fly   558 TVGSAGSSYLINDGKK----TSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICY 618
            .|||......:.:.::    .:..:|..|.:::.:.|:.||::...:.|..:..|: :..::|.|
 Frog   613 KVGSEDKEGEVQEEEEEVEDENDIMKVLGKLVQAMFVKYWIYVCGGMFFFVSFEGK-IVMYKIIY 676

  Fly   619 MALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKD 683
            |.||||.:.::|...:.|.:|:..||:.::.|.|.:|:.||||||..|...|.:...:......|
 Frog   677 MMLFLFCVALYQVHYEWWRRILKYFWMSVVVYTMLVLVFIYTYQFKSFPGLWMNMTGLDKEKLAD 741

  Fly   684 IGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRF--------IASLQQQPLAG---------- 730
            :||:.:...|||..:..||..:::.::.:||||.||        :.|.|...:..
 Frog   742 LGLETFNLTDLFTRIFIPTSFLLVCILHLHYFHDRFLQLTDLKAVTSKQDSTIYSHAKVNGRVYL 806

  Fly   731 --GSAQQK-PTE-------------------TTALEPAPSKR-------------------RGSA 754
              .|.:|| |.:                   ||..|....||                   :|.:
 Frog   807 IINSIKQKIPIQQNELVHPEGSLPDITMMNLTTESEMLEEKRLEIYDEKKTHDQDSDDEWDKGDS 871

  Fly   755 GSLRKSQGPSAEAAPGATTDFETS----------VRDLVRISFRKIKNKSEYIFKNFKDVFWRFL 809
                |..|.|.:.|....::.|.:          |.|.:.:.|.|.   .|| |..|:...|..|
 Frog   872 ----KEPGHSDDEAEDEESEEEETTTESRNKWHLVIDRLTVLFLKF---LEY-FHKFQVFVWWLL 928

  Fly   810 ELHIMKAVYIAAFVCSVSEVCVL-HIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQ 873
            |||::|.|.......::.||.:| ::.|:.:..  |......:.:.|.:.:....||::.||:||
 Frog   929 ELHMIKIVSSYIIWLTIKEVSLLNYVFFIAWAF--ALPYSQFRPLASSVCTVWTCVIIICKMLYQ 991

  Fly   874 IEYLSHS---------QHNVVCSDNRTANN-----------AEWIGLTKADKVTGGLMSLLRTYI 918
            :..:..:         |.|...:.|:|..|           :.|:||.|:..    |::.||..:
 Frog   992 LASIDPATFSSNCLMPQLNETTARNQTELNSSVLYNSSVDPSNWVGLKKSTP----LLAYLRNNL 1052

  Fly   919 IYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIE 983
            :.:.::.....|...|...|:: ..|..|.||.:|.:|.|...:..|:...||.:|:.|||||:|
 Frog  1053 LMLAMLAFEVTIYRHQEYYRLR-NNLTTPATKTIFHDITRLHLDDGLINSAKYFVNYFFYKFGLE 1116

  Fly   984 ISLIALVSTITYRQDIVAVVYALWLV-VLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPS 1047
            ...:..|:.|..|.|..|:|:||||. ||...||...|:.|..:..|.|..:..||.:.:|:||:
 Frog  1117 TCFLLSVNVIGQRMDFFAMVHALWLFGVLYRRRRKAIAETWHRYCCFLACIMAFQYFICIGIPPA 1181

  Fly  1048 SCLVFPWDE--GPFGEGIQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDY 1110
            :|..:||.:  ..|...|.:|...|..:.......|::||::|:..:.|:.:|..|.:.|..  .
 Frog  1182 ACKDYPWRQPGANFNSNIIKWLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVR--I 1244

  Fly  1111 PGGSNRSVI--ADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIAD 1173
            ..|.|..:.  .|.|...:   .||..||. |.|:|.|:.|..:....:||.|.::|:.||....
 Frog  1245 MAGDNVEICMNLDAASFSQ---HNPVPDFI-YCRSYLDMGKVIMFSYLFWFVLTIIFITGTTRIS 1305

  Fly  1174 LLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTKDCC 1238
            :..:|||:..|.||..|.|..|:||..|:..|.||:|:||..|.:|....:..|.::..|.||.|
 Frog  1306 IFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMKNVLSIGACGYIEYLIKDSC 1370

  Fly  1239 WLVHMLGITCTSNVLTEQIMLPEEAELALKPGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYF 1303
            ||:....::||    .:...:|:...      :|...:.:..::||:|||||::.|.|:|.|:||
 Frog  1371 WLIQAFSLSCT----VKGYFIPQNTP------DCQLPSGEAGIIWDSICFAFLLLQRRVFMSYYF 1425

  Fly  1304 CHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQT 1368
            .|::.|.|::.|||||||::.::...|.:..|.:.||:.:.::||:|:.|:|.|:|..:..:|..
 Frog  1426 LHVVADIKSSQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDHIKARQEKYKKGKEKML 1490

  Fly  1369 HF-----------------DGRRTPSEHAMSDV----APLVHNSSFTSCQGSGYL---TPDEHSS 1409
            ..                 :|.:...|.|....    .|.|.::|... .|..||   ..:|...
 Frog  1491 SLTQDGEGQEVQKLDDDDEEGDKADKEKAKGKKKQWWRPWVDHASMVK-SGDYYLFETDSEEEDE 1554

  Fly  1410 ATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYV-------------DVQ 1461
            .......|.|.|....:.|...|      |:|..|:..:.....|..|:             |.:
 Frog  1555 DDKKEEEPRRKSAFQRAIGKFAS------AIIALPKSVIKLPKTILQYLIRAAKFLYQAWITDPK 1613

  Fly  1462 SV-------SEEETTVAMPKKDLS-------CQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLE 1512
            :.       ::||....|.:|.::       |..||   :..|..|..:...|.:.
 Frog  1614 TALKQRSMEAKEEKAREMRRKGIAEGDIIVECGDKE---EEKEQGKKKSDGPDNIF--------- 1666

  Fly  1513 PKRISLGLAPPELSPPVGMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVS 1577
             |||.                   .:..:...:..:...|.  |....::.|||         :.
 Frog  1667 -KRIF-------------------NILKFTWVLFLATIDSF--TAWLNSISREH---------ID 1700

  Fly  1578 WNETVSIKRSPMKKQMSADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARD 1642
            .::.:||:|..:.:::.  |..|.|  .:|:|..:|:....|.|.:           |.|....|
 Frog  1701 ISKVLSIERCMLTREIK--KGNVPT--RESIHMYYQNQIMMSLSRE-----------SGLDRIDD 1750

  Fly  1643 EAALRSAQRPHSWGPVGTSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEID 1707
            :....|:...|.                                 .|..:..|..:..:.||.|
 Frog  1751 QPGSSSSHHSHD---------------------------------KMASKRMDSADSAVSHDSI- 1781

  Fly  1708 FLEEENITESEMKMQRRKTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEKEKIGPD 1772
               ....||:.|...|:.||.|                                ||      |||
 Frog  1782 ---SSCCTEATMLFSRQSTLDD--------------------------------LD------GPD 1805

  Fly  1773 LGLASDHDEDDDTIECDLGMRTSTLSEPLDFGRRSQTLLEVKSKDAPTGEFPSTSKGISKERDAA 1837
                                     |.|....|..                |...|..|.:..::
 Frog  1806 -------------------------SVPKTSERAR----------------PRLRKMYSMDMSSS 1829

  Fly  1838 TASSSASPAPTRDV------GDLPVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDF 1896
            :|.|.||..||:..      |....|        .|...:|..:|||.:    .::.|::.:.|.
 Frog  1830 SADSIASSEPTQCTMVYSRQGTTETI--------EEVEDEEEEESKSPL----SKIEAEEEEYDM 1882

  Fly  1897 DTNPIIRLLEGFLVTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSN 1961
            |       |||...|
 Frog  1883 D-------LEGTSYT-------------------------------------------------- 1890

  Fly  1962 LESDESEPPASSSTPRRVVIAPPN---ATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTT 2023
               .::|.|..::|...:   ||:   |......|..:.::......|||.|
 Frog  1891 ---PDTEFPLYATTEGDL---PPSYSKAGSFEQLTFVSQDSADNLMVLSPDE------------- 1936

  Fly  2024 STPQQQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGTMLSRKSDCGLPEIRIKAPSIER 2088
            |...:.|.||                                          ||.:
 Frog  1937 SRTDKLHDHI------------------------------------------LPPL--------- 1950

  Fly  2089 GAHYYHNHHSGGGSGSLSKHWSYEQVDSAGEFNLEEENFAQRDHHIIVEVLISSWY-ALLANTDL 2152
                  .|........|:|.:..|:::.:.:|...:....|         ||.:.| .|:|.:::
 Frog  1951 ------THELTASELLLNKMFYDEELEDSEKFYTTQPRPLQ---------LIYALYNTLVARSEM 2000

  Fly  2153 ICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI-W 2216
            :||.|:.:|.:::||:|:|.|||::|||..||:|||:|.||:|.|.||:..::||..|||... |
 Frog  2001 VCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPW 2065

  Fly  2217 S-NYHQLPNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPT 2280
            : |.....::|..|..|.|:|.|..|..|||:.||.||.||.:||..|||     |.|:...|.|
 Frog  2066 NKNVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLW-----DEDDVTEKAT 2125

  Fly  2281 ASIDERDDSD-NLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQ---------LERTK 2335
                ::||:| .:|:...|:.:..:.:.::|..|..|:.......||.|.:         ..|:.
 Frog  2126 ----DKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSS 2186

  Fly  2336 YTS----------------------------------------------------SLY----KFF 2344
            |:|                                                    .:|    :||
 Frog  2187 YSSHRSKRGSTSTRNSSQKGSSIPSIKLKSRKELILEKLREQLIKAKAFTIKTILQIYVPIRQFF 2251

  Fly  2345 FSLVHKSRLA-TDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLL 2408
            ::|:|....| ||||.||||.|.|:|.:::|||.|||.....:|  :.:.|:|::||..||:|:|
 Frog  2252 YNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAAD--ITSSLSEDQVPEAFLVMVL 2314

  Fly  2409 VQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYM 2473
            :||..:|:||||||||.::.|:||....|.|||.||||::|.||||.|:......::|.:||.|.
 Frog  2315 IQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYF 2379

  Fly  2474 LLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKM 2538
            .||:|||:.|||.|:||||.||.::.||:..|:.:..:|||.|||.::|||..|:|:::..|:.:
 Frog  2380 GLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICV 2444

  Fly  2539 EDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAV-GTS 2602
            |||:::|::::|.|:||..:|..|.|||..:.|..|||.|::|::..:|.||...:|..:| |.:
 Frog  2445 EDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVT 2509

  Fly  2603 NVPFHVSLSIRIGPYDPIYTTN-NYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVR 2666
            |.|..||::|.:|.|.||:|.: ..:.:..:|...:..:.|.|.....|:.|:..|...|:....
 Frog  2510 NKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAG 2574

  Fly  2667 LAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGR 2731
            |.|||.|||.|:||.|..::..|.......|..|:|:.|........|..|:::.|||  :.:.|
 Frog  2575 LEGNSNSLWTISPPSRTMMIERLIQEPDFTAVISWSIRRNVSLGAKAEVTGEKYTISL--AGQTR 2637

  Fly  2732 AALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYR 2796
            ..|..|:               |.::|  .:.|.:..:.|..:|..:...|..:..|. |:.::.
 Frog  2638 RELADMM---------------NSSSP--NKTVELIKIYPLCLKAPSDVTAKPILQLL-KNQEFV 2684

  Fly  2797 PLVIKMHRDNETNGL--WWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTA 2859
            .:.:.:.::|.:.|:  ||.:         |::..:|...:   |:.::.|:||..|.:..||..
 Frog  2685 NISVLLRKENTSEGVREWWVV---------NQSHKEFIKKD---GLELWVFSDKVSPPSLGFLAG 2737

  Fly  2860 GGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAK 2924
            .||:|||.:.||:..:|::.|..|.:..||||:||.|||:|:||.||:||||..|..|||||:||
 Frog  2738 YGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAK 2802

  Fly  2925 LLFLYRSPETLIKWTRPKEE 2944
            |:||||||||:|||||.|::
 Frog  2803 LIFLYRSPETMIKWTREKDK 2822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Piezo	NP_001303314.1	PIEZO	1226..>1363	CDD:292539	45/136 (33%)
		Piezo_RRas_bdg	2511..2941	CDD:288978	148/433 (34%)
piezo2	XP_012820813.2	PIEZO	1357..1622	CDD:406366	67/281 (24%)
		Piezo_RRas_bdg	2416..2819	CDD:403405	148/434 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I541
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49695
Inparanoid	1	1.050	1074	1.000	Inparanoid score	I247
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13738at2759
OrthoFinder	1	1.000	-	-		FOG0001637
OrthoInspector	1	1.000	-	-		mtm9559
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1528
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060