DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Piezo and piezo2a

DIOPT Version :10

Sequence 1:NP_001303314.1 Gene:Piezo / 34112 FlyBaseID:FBgn0264953 Length:2973 Species:Drosophila melanogaster
Sequence 2:XP_073797454.1 Gene:piezo2a / 100334952 ZFINID:ZDB-GENE-131119-76 Length:2753 Species:Danio rerio


Alignment Length:3282 Identity:829/3282 - (25%)
Similarity:1350/3282 - (41%) Gaps:869/3282 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVFSYACMVLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLT 65
            |.....|.::.|:::|..|..|.|.|...:|||||:...:.|.....|.....|.......:|..
Zfish     3 MASELLCGLIFRLLLPVCLAAACLFRYNWLSFVYLVFLLLIPLFAEPTHATMTGHTGRLLKVLCL 67

  Fly    66 LSTLVLLGHITLQILAVSLTL-----PIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLVF 125
            .|...||.||..||...||..     |.:|||..||.:|.|||.|.........|...:|::.:|
Zfish    68 TSVTFLLLHIIFQITVNSLIAGESIQPRFNCSSWERSIRQIGFESVRGADAGNGIRVFIPDIGMF 132

  Fly   126 ATSLGSYLTVKRVASQPVGAEQLENG--------------------------------EVVDGQA 158
            ..||.::|..:.:....:..:...|.                                |:.||..
Zfish   133 VVSLVTWLLCRSLEKPSIKEDSQHNSDFEVDNQEKEDEEEDENREKRELEDELLFEDFELRDGDC 197

  Fly   159 ENAQT-SSQPSAADANGG-----DVQQATVTTPLQQQQQQLRKRVSMISQHIHFEGLVKISPLFC 217
            |..:. ..:..||||:.|     |::::|.|..|:|......|...::...|...|.|.::.|  
Zfish   198 ELPENEEEEEEAADADDGDLEEPDIEESTKTRILRQIADAASKLKEIVGNLITSAGKVVVTVL-- 260

  Fly   218 LATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQRGFALLLRCVMVVLVL----HSLSIVSY 278
               |....::.||:....||..||...|:|:.|::..   .||..|:.|::.:    |.:.:..|
Zfish   261 ---LGLTGMMLPSLTSSVYFFTFLGLCTWWSFCRSFD---PLLFSCLCVLMAIFSAGHLVFLYLY 319

  Fly   279 QTPWMQSHLNHTTLTARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTK 343
            |..:.|..:......|.|.|:.|::::.|| ...:|..|..|....::||..|...|:.||.   
Zfish   320 QFQFFQEAVPPGNTYASLFGISPVVQTDCS-HTWMFKVNPALEWHHFVNPIMLLVLYYTLAT--- 380

  Fly   344 HLIKPRLVRQSTRKARTPQPLESGSSVAPS----------------------------------- 373
             ||:..|......:.|..:......:.:|.                                   
Zfish   381 -LIRLWLQESEDTQVRDAEAEGKDDAASPENTDINVYTADQRRQLWRMAHYHTDERNLLTAQEAY 444

  Fly   374 -------VTQRGNDMQLESMEQ-----------------RSEQENTTTSILDQISY--------- 405
                   ||..|..:...|:..                 :::|..:.|..||...|         
Zfish   445 NSPEVLIVTSNGASLDFTSVSHEKRTKCVERNLYSTPHYKADQPESDTQSLDCGVYRIDSAYVEL 509

  Fly   406 -----------GFVSVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMM 459
                       ..|.|..||.:.|||...|.||||||.|.||||||.|:.:..|||:.::||..|
Zfish   510 SELPVAVVRVNSVVKVFRFIMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKYSM 574

  Fly   460 RSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAF 524
            .:|||:|.|...|:|.|||:..:...       |..|:.|::   |.|...       |..||..
Zfish   575 VTSPFMVFYGNLLIILQYIWSFECLQ-------PVPGLFLKK---EVPFRE-------LGSKTLC 622

  Fly   525 VLMFWVTSRQFFKEKRDRRRDS-TLADFIAPLQITVGSAGSSYLINDGKKTS---------KFLK 579
            :|.||:..|||..|:|::..|. .|:|      :||          ||.|..         :.::
Zfish   623 LLSFWLLLRQFLTERREKHTDDPQLSD------VTV----------DGHKLGLQDEAAGHREMME 671

  Fly   580 KAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFW 644
            ..|..:..:|.:.||::...:.|..:..| .:..::|.||.:|||.:.::|...:.|..::..||
Zfish   672 VLGSSLMAMLNKYWIYICGGMFFFVSFEG-RIVMYKIIYMMMFLFCVALYQLHYERWRWMLKYFW 735

  Fly   645 LFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTV 709
            :.::.|.|.:|||:||:||:.....||:...:|....:|:||:::....||..:..||..:::.:
Zfish   736 MSVVVYTMLVLILVYTFQFESSINVWSNMTGMSREKLEDLGLEKFSVPALFTRIFIPTWFLLVCI 800

  Fly   710 IQVHYFHKRF--------IASLQQQPLA-----GGS----AQQKPTETTALEPAPSKRRGSAGSL 757
            :.:||||:||        :|..|:..::     .||    :..|||..:..|....|:.....:.
Zfish   801 LHLHYFHERFLELTDIKTVADKQKSTISRLVHLDGSLVDISMIKPTFNSTNEEEVEKQEDEEDNN 865

  Fly   758 RKSQGPSAEAAPGATTDFETSVRDLVRISFRKIKN-------------------KSEY------- 796
            ..::....:..      .|....|:.:...:|:::                   ||::       
Zfish   866 YHNEDEDEDER------VELEEEDVKQTEEQKMEDSLFTCPMTADPVLEQTSELKSKWHLVVERL 924

  Fly   797 --IFKNFKD-------VFWRFLELHIMKAV--YIAAFVCSVSEVCVLHIIFV-------GFCVLG 843
              :|..|.|       ..|..|||||:|.|  || .:|| |.||.:.:.:||       .||   
Zfish   925 TVLFLKFLDCIQKLQLFIWWILELHIIKIVSSYI-IWVC-VKEVSLFNYVFVVSWAFALPFC--- 984

  Fly   844 ATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCS--DNRT--------------- 891
                 ..:.:.|.:.:....:|::.||:||:..:|.:.:...||  ||.|               
Zfish   985 -----QFRPLASSVCTVWTCIIIVCKMLYQLTSISPAAYARNCSMPDNYTEAQRMDMAKSLLYIG 1044

  Fly   892 -ANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPN 955
             .:.|.||||.|...    |:..||..::.:.::.....|...|...|:| ..:..|.|:.:|.|
Zfish  1045 PVDPANWIGLRKFSP----LLEYLRNNLLMLALLAFEVTIYRHQDFYRMK-NNITPPVTRTIFHN 1104

  Fly   956 IIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQC- 1019
            |.|...:..:|...||.:|:.|||||:|...:..|:.|..|.|..|:::|..|:.::..||.:. 
Zfish  1105 ITRQHLDDGIVNCAKYFINYFFYKFGLETCFLLAVNVIGQRMDFFAMLHAFGLIAVMYQRRRKAI 1169

  Fly  1020 AKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPW--DEGPFGEGIQRWAMLPGALHFNHVPK-- 1080
            |.:|..:..|.|..:..||::.:|:||::|..:||  ........:.:|...|   .|:..|.  
Zfish  1170 AHVWSKYCCFLACLLSFQYLMCIGIPPAACTDYPWRRSSSSMDSNVIKWLYFP---DFHTKPNSL 1231

  Fly  1081 -LIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFD--NPTHDFCSYIR 1142
             |::||::|:..:.|..:|  |:...|......|.|..:..|   |....|.  ||..||. :.|
Zfish  1232 FLLYDFMLLLCASLQGRVF--EEECVSPVQLLAGDNVEICRD---LDAATFSQHNPVPDFI-HCR 1290

  Fly  1143 NYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKW 1207
            :|.|:||..|....:||.|.::|:.||....:..:|||:..|.||..|.:..|:||.:|:..|.:
Zfish  1291 SYLDMLKVMVFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLIFGGELLLKPIKSILHYWDF 1355

  Fly  1208 LLAFNVANILIKTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPGEC 1272
            |:|:||..|.:|....:|.|.::..|..:.|||:.:..:.||....::    ||:.  |.|..|.
Zfish  1356 LIAYNVFVITMKNILSIAACGYIKALVANHCWLIQLFSLACTIKGYSK----PEQQ--ANKQCEL 1414

  Fly  1273 PKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHD 1337
            |  :.:..::||:|||||::.|.|:|.|:||.|::.|.:::.:||||||::.::...|.:..|.:
Zfish  1415 P--SDEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRSSQLLASRGAELFQATIVKAVKARIE 1477

  Fly  1338 HEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAMSDVAPLVHNSSFTSCQGSGYL 1402
            .||:.:..:||:|:||::.|||..|         |:    |..:|                    
Zfish  1478 EEKKSMDLLKRQMDRIKSRQQKFKR---------GK----ERMLS-------------------- 1509

  Fly  1403 TPDEHSSATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYVDVQSVSEEE 1467
                                |:...|...||                             :.|||
Zfish  1510 --------------------LAQESGERHSV-----------------------------LKEEE 1525

  Fly  1468 TTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLAPPELSPPVGMQ 1532
                                                                             
Zfish  1526 ----------------------------------------------------------------- 1525

  Fly  1533 CLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSIKRSPMKKQMSADK 1597
                                                                           ::
Zfish  1526 ---------------------------------------------------------------EE 1527

  Fly  1598 EEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARDEAALRSAQRPHSWGPVGTSS 1662
            ||                       :|:|:.::|       |.|.:           |       
Zfish  1528 EE-----------------------EESSKEKKK-------GKRKQ-----------W------- 1544

  Fly  1663 YMESLMCAFYEPALLHGPSTRAGDYYMF-------EEMDDKFELDLIHDEIDFLEEENITESEMK 1720
                     :.|.:.|....|:|:||:|       ||.:|:.:.:.......|:....||:|:..
Zfish  1545 ---------WRPWVDHASMVRSGNYYLFETDSEEEEEDEDRKDEEPKRSAFQFVYHAWITDSKTA 1600

  Fly  1721 M-QRRKTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEKEKIGPDLGLASDH--DED 1782
            | :|||.....|:...::...:    ||:..|:     :.::..|:.       |:..|.  |..
Zfish  1601 MKERRKEKRRFWQKYTESNTNK----REQKEAN-----VTVEEGDQD-------GVTEDELSDSP 1649

  Fly  1783 DDTIECDLGM------------------RTSTLSEPLDFGRRSQTLLEVK----SKDAPTGEFPS 1825
            |:.::....|                  ..|...|.:|.    .::|.::    :.:|..|..||
Zfish  1650 DNMMKRVFNMVKFSWVLFLALLDSFTAWLNSICQEHIDI----SSVLRIERCMLTHEAKKGNVPS 1710

  Fly  1826 TSKGISKERDA----------ATASSSASPAPTR----DVGDL---PVIPPPSTGLGREQTSKET 1873
                    ||:          ..||:.:|..||.    |...|   |.:||      :|.|..:|
Zfish  1711 --------RDSIRMYYQRQMCRPASTQSSLEPTEEAYSDFSPLRTDPDLPP------QEHTELQT 1761

  Fly  1874 S-DSKSKMEVDSGEVTAKDSDEDFDTNPIIRLLEGFLVTLTIRLNRFSRNYRFVNRILAGEKKTL 1937
            | ::.:.:..:|..|.....||:                                |:|   |.:.
Zfish  1762 STENLASVYTESSIVEDSTLDEE--------------------------------RVL---KTSQ 1791

  Fly  1938 KESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSSTPRRVVIAPPNATEHSDPTSTTLNTNTT 2002
            :....|.|:             |.::...|...|:||             |.:..|.......|:
Zfish  1792 RSRPKLCRI-------------SGVDVPSSADSAASS-------------ERTQGTELYSRQGTS 1830

  Fly  2003 TTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGTM 2067
            .|          ::....:|..:         :|.::::.|        ||     ..||:....
Zfish  1831 DT----------VEECGADTLWS---------SASDLLQTP--------HR-----DVPPSYSRA 1863

  Fly  2068 LSRKSDCGLPEIRIKAPSIERGAHYYHNHHSGGGSGSLSKHWSYEQVDSAGEFNLEEENFAQRDH 2132
            ......|...:::|:.|..........:.|....|..|.....|:.       :||:.....|..
Zfish  1864 TGLDCICDERKLKIQTPEDSSSGTPQTSSHRLTASELLQTRMFYDA-------DLEQSERFYRSQ 1921

  Fly  2133 HIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLI 2197
            ..::::..|.:..|::::.::||:|:.:|.:::||:.:|.||:::|||..||:|||:|.||:|.|
Zfish  1922 PQLLQLCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAI 1986

  Fly  2198 AYTQAIVLIKCIFQFKLIWSNYHQL----PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYL 2258
            .||:..::||..|||...  .::|.    .::|..|..|.|||.|..|..|||:.||.||.||.:
Zfish  1987 VYTEVTIVIKYFFQFGFF--PFNQSIEVDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSI 2049

  Fly  2259 LKSQGLW-------------------------KSGYKDTDNQFT------------KPTASIDER 2286
            ||..|||                         ||..:||   :|            |..:|...|
Zfish  2050 LKCYGLWDEEEPRSVSPHTHSGAEEKAECFSEKSPVEDT---YTRTLSHTHLRLARKQQSSAGVR 2111

  Fly  2287 DDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYK--------- 2342
            ..|.::||..:|       .|....||::|:..|....:....:|...|....|.:         
Zfish  2112 RQSSSISQRSAR-------SKTGSSVSRSSVRRSLSAQQKSRKELLMEKLREQLIRAKRFTVKTV 2169

  Fly  2343 ---------FFFSLVHKSRLA-TDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAEN 2397
                     ||:||:|....| ||||.||||.|.|:|.:::|||.|||.....:|  :.:.|:|:
Zfish  2170 LDVYIPIKQFFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAAD--ITSSLSED 2232

  Fly  2398 KVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPP 2462
            :||..||:|:|:||..:|:||||||||.::.|:||....|.|||.||||::|.||||.|:.....
Zfish  2233 QVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVA 2297

  Fly  2463 IIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCID 2527
            .::|.:||.|..||:|||:.|||.|:||||.||.::.:|:..|:.:..:|||.|||.::|||..|
Zfish  2298 QLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTD 2362

  Fly  2528 STMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCL 2592
            :|:::..|:.:|||:::|::::|.|:||..:|..|.|||..:.|..|||.||:|::..:|.||..
Zfish  2363 TTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLF 2427

  Fly  2593 FALGNAV-GTSNVPFHVSLSIRIGPYDPIYTTN-NYDSIFEINPEMYSQMTNAYIKEKQALTFIA 2655
            .:|..:| |..|.|..||::|.:|.:.||:|.: ..:.:.|:....:....|:|.....|:.|:.
Zfish  2428 MSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLE 2492

  Fly  2656 GYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEH 2720
            .|.|.||....|.|:|.|||.|:||.|:.|::.|..........::|:.|........|...|:|
Zfish  2493 AYRAEDVTVAELEGSSNSLWTISPPSRKNLMDVLSKEDQFPVTMTWSIQRNLSLGAKSEFAMDKH 2557

  Fly  2721 AISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVV 2785
            ...||  .:.|..||.:|           |||.|  ||     |:|..:.|.||:..:..:|..:
Zfish  2558 VTYLD--IKTRQELIALL-----------NGTRN--TP-----VLIEQVFPCFIRAPSDSNAKPI 2602

  Fly  2786 SVLSPKHYDYRPLVIKMHRD-NETNGL--WWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYTFND 2847
            ..|. :..||:.:.:.:.|. |.:..|  ||.:          :.|.........:|:.:|.|:|
Zfish  2603 EQLY-EDGDYKSIQLDLERSANSSEDLQEWWIV----------DELRSAQKQQREAGLQLYVFSD 2656

  Fly  2848 KKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREA 2912
            |..|.:..||...||:|||.:.||:..:|::.|..|.:..||||:||.|||:|:||.||:||||.
Zfish  2657 KVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRET 2721

  Fly  2913 LEFALEEDLFAKLLFLYRSPETLIKWTRPKEE 2944
            .|..|||||:|||:||||||||:|||||.|.:
Zfish  2722 GELELEEDLYAKLIFLYRSPETMIKWTREKNK 2753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PiezoNP_001303314.1 PIEZO 1226..>1386 CDD:464941 50/159 (31%)
Piezo_RRas_bdg 2511..2941 CDD:463481 157/434 (36%)
piezo2aXP_073797454.1 None

Return to query results.
Submit another query.