DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbsn-5 and Rbsn

DIOPT Version :9

Sequence 1:	NP_609186.1	Gene:	Rbsn-5 / 34110	FlyBaseID:	FBgn0261064	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001101345.1	Gene:	Rbsn / 312562	RGDID:	1305397	Length:	783	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	153/524 - (29%)
Similarity:	247/524 - (47%)	Gaps:	78/524 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SGEILEGFLCPICRADLKSIDVLTDHFARQHAEEEDALKSFKDIFTKAKK---KILNPFEDEKGA 77
            :||:.||||||:|..||:|...|..|:..:|:.:.|.....|::..||:|   |:|....|:: .
  Rat     7 AGEVREGFLCPLCLKDLQSFYQLQSHYEEEHSGDRDVKGQIKNLVQKARKAKNKLLKREGDDR-V 70

  Fly    78 SVSSPAGSSSSAAGKNPNGNGDRNGPSNARSRLNVFNYM-ARQQPGAECSHFEYFQSIRNPRLER 141
            ...:....|.|..|.:|                    || ..|:.||..||...|:..|..|::.
  Rat    71 EPGTQGYESFSYGGVDP--------------------YMWEPQELGAMRSHLSDFKKHRAARIDH 115

  Fly   142 YASETNKLIIRLHRL--LKDLPADSVQRRQHEQQTVAWLDGSSVKLCPSCAKSFHIARRQHHCRL 204
            |..|.|||||||.:|  ......::.:.|..|:..|.|::...|..||.|...|.|..|:|||||
  Rat   116 YVIEVNKLIIRLEKLTAFDRTNTETSKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRL 180

  Fly   205 CGGIMCNDCSKFLPLEDAMQLASLS----TTRSEPLQ---QLH-------------------QHE 243
            ||.|||..|.:.:.|..|.:|.|.|    :|.:.|.|   .:|                   :.:
  Rat   181 CGSIMCKKCMELIGLPLANKLTSASKDSLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDD 245

  Fly   244 NAIRLCEHCLWLLDTRKDMHESRTCRPLLVQVYEQIRQLQKEVTPDLDMYLKIINSLNEGDTIFT 308
            ..||.|.||...|..|:...:.:...|.:|::||::|...::|......|:::..|||.|:|.::
  Rat   246 ERIRCCTHCKDTLLKREQQMDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYS 310

  Fly   309 LADAGALRGKIGQVAEAMDMRSKRILAIFC----EPGSREEALKKAIRLGCIQAIKERMLSLPPL 369
            |..|..||.::.:|.|.:|..||:||.:..    .|......|::.||......::|::|.|..|
  Rat   311 LEHANDLRVEVQKVYELIDALSKKILTLGLNQDPSPHPNTLRLQRMIRYSATLFVQEKLLGLMSL 375

  Fly   370 PEESHIRQMQERRRMETEQRILTEQRMAMEAYERNNMAANQSNVGVPGPESGSFAQGSDLQSLNN 434
            |.:....:::::|:.:.||:...|::.|:|:  |..:...||.:       .|.....|::||..
  Rat   376 PTKEQFEELKKKRKQDLEQKRTMERQAALES--RRKLEERQSGL-------ASHTANGDMRSLQG 431

  Fly   435 WSAP-----------QAASKSSLDDPLIEQINIIKGYIKQARQDMNFEVVETLELNLRELQREVY 488
            ..||           :...:|...|||::||..|..:|:||:.....:.|.||:.|||:||.| |
  Rat   432 IPAPLRKAEGWLPLSEGQVQSEDPDPLLQQIYNITSFIRQAKAAGRTDEVRTLQENLRQLQDE-Y 495

  Fly   489 ERQR 492
            ::|:
  Rat   496 DQQQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbsn-5	NP_609186.1	FYVE_RBNS5	174..259	CDD:277256	35/110 (32%)
Rbsn-5	NP_609186.1	Rbsn	449..487	CDD:288341	16/37 (43%)
Rbsn	NP_001101345.1	FYVE_RBNS5	150..261	CDD:277256	35/110 (32%)
		Rbsn	460..498	CDD:402875	16/38 (42%)
		NPF	548..726	CDD:406900
		Rbsn	740..778	CDD:402875
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351776
Domainoid	1	1.000	74	1.000	Domainoid score	I8961
eggNOG	1	0.900	-	-		E1_KOG1842
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41477
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3608
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005770
OrthoInspector	1	1.000	-	-		oto96284
orthoMCL	1	0.900	-	-		OOG6_105165
Panther	1	1.100	-	-	LDO	PTHR13510
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4165
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.750