DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbsn-5 and pep7

DIOPT Version :9

Sequence 1:	NP_609186.1	Gene:	Rbsn-5 / 34110	FlyBaseID:	FBgn0261064	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_594255.1	Gene:	pep7 / 2542423	PomBaseID:	SPAC17G6.08	Length:	536	Species:	Schizosaccharomyces pombe

Alignment Length:	588	Identity:	116/588 - (19%)
Similarity:	200/588 - (34%)	Gaps:	208/588 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SASGEILEGFLCPICRADLKSIDVLTDHFARQHAEEEDALKSFKD---------------IFTKA 63
            |.|..|::...||||..:|.::..|.||....|..:.:.:...:|               :..||
pombe    30 SDSSNIVKATECPICGLELPNLSALNDHLDVTHFNDNEKIHKRQDSINSWLTRTLNGASALQMKA 94

  Fly    64 KKKI--LNPFEDEKGASVSSPAGSSSSAAGKNPNGNGDR-------------------------- 100
            .:::  :.|:|..         |.||.|.|.......|.
pombe    95 AQRLWRMEPYEQN---------GDSSGAVGLEATKLTDSLVVKNHWQPEVPDMVCHDPMCDKLLN 150

  Fly   101 --NGPSNARSRLNVF-NYMARQQ---------------------------PGAECSH------FE 129
              ||..:.|....:| |:.:..|                           ||...|:      |:
pombe   151 FINGHIHCRKCGYIFCNFHSMYQIKLSIHATYDSENGFWCRVCRECYEGRPGYNDSNGLIRSRFQ 215

  Fly   130 YFQSIRNPRLERYASETNKLIIRLHRLLKDLPADSV---------QRRQHEQQTVAWLDGSSVKL 185
            .|::.|.|..::...|..:|..|:.:|.:...:::|         :.::.||..|.|.|.|.|::
pombe   216 TFETFRKPLADKRRIEFLRLSKRMKKLEELWTSENVSMLDALLLNKAKRLEQSIVHWQDDSVVQI 280

  Fly   186 CPSCAKSFHIARRQHHCRLCGGIMCNDCSKFLPLEDAMQLASLSTTRSEPLQQLHQHENAIRLCE 250
            ||.|..||.:.||:.||||||.::|..|        .::::            |.||...:.:|.
pombe   281 CPECNNSFTLTRRRRHCRLCGRVICRFC--------VLEIS------------LPQHPQPLLICM 325

  Fly   251 HC--------LWLLDTRKDMHESRTCRPLLVQVYEQIRQLQKEVTPDLDMYLKIINSLNE---GD 304
            .|        |:..:..|.:...|....|  ||:.|..         ::.|....:||:|   |:
pombe   326 SCNQNYFRNVLYQTERSKSLGYIRHIEHL--QVFRQAM---------VNYYRLYEDSLSELLSGE 379

  Fly   305 TI--FTLADAGALRGKIGQVAEAMDMRSKRILAIFCEPGSR--EEALKKAIRLGCIQAIKERMLS 365
            .|  .||......|.|..::....|...|:|..   .|.|.  ||..|:.:.....:.::|.:|.
pombe   380 IITEATLKIVKDRRKKFLELCVKYDGTMKKIAN---HPSSNDAEEQFKQNVVNEAKRYLQETILR 441

  Fly   366 LPPLP----------EESHIRQMQERRRMETEQRILTEQRMAMEAYERNNMAANQSNVGVPGPES 420
            |..:|          .||.....:::.::|.:|..|.:.|:.:|
pombe   442 LQAIPYHLQVGQAWTSESERELEKKKEQVEKKQEELMQTRIVLE--------------------- 485

  Fly   421 GSFAQGSDLQSLNNWSAPQAASKSSLDDPLIEQINIIKGYIKQARQDMNFEVVETLELNLRELQR 485
                                           ||:.:::..|:.|:....|..||||..:|..|..
pombe   486 -------------------------------EQVFLVENMIEDAKAKRKFSEVETLLSSLAPLHE 519

  Fly   486 EVY 488
            |::
pombe   520 EIH 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbsn-5	NP_609186.1	FYVE_RBNS5	174..259	CDD:277256	26/92 (28%)
Rbsn-5	NP_609186.1	Rbsn	449..487	CDD:288341	11/37 (30%)
pep7	NP_594255.1	FYVE1_Vac1p_like	128..205	CDD:277300	8/76 (11%)
		FYVE	271..333	CDD:214499	24/81 (30%)
		Rbsn	483..522	CDD:288341	13/90 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1671
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005770
OrthoInspector	1	1.000	-	-		oto100840
orthoMCL	1	0.900	-	-		OOG6_105165
Panther	1	1.100	-	-	LDO	PTHR13510
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8149
SonicParanoid	1	1.000	-	-		X4165
TreeFam	0	0.000	Not matched by this tool.
	9	8.980