DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAPLA1 and DDL1

DIOPT Version :9

Sequence 1:	NP_609185.1	Gene:	PAPLA1 / 34109	FlyBaseID:	FBgn0031990	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_014665.1	Gene:	DDL1 / 854187	SGDID:	S000005548	Length:	715	Species:	Saccharomyces cerevisiae

Alignment Length:	804	Identity:	180/804 - (22%)
Similarity:	262/804 - (32%)	Gaps:	327/804 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1373 YSPVVAHWFYKRSVDT---------------KFIWTPFSHYDSALLETSLNLDDSTLIIPVEGGR 1422
            |.|    |||...|..               ||  .|||..||..||.:....:...::..|...
Yeast    26 YVP----WFYAIDVPNSKPYLPTYQTLHSPKKF--KPFSVDDSNRLEKASKRQERRPVLVNEDYL 84

  Fly  1423 YDVNIKERTKTPVYWEGKAIEVRRCSWFYKGVDSKYVPYTEDTAALLEAEYKR------------ 1475
            :.|::.....:|.||||...:|||..||    ||...|.:.|..:.:|..||:
Yeast    85 FKVDLSHMELSPTYWEGPTYQVRRGVWF----DSSNQPLSSDLTSEIEGLYKQLKFDDSNDDPTT 145

  Fly  1476 --SAET---------------GEWHQK---------------IMLANGEQVVF-----HGPTVIV 1503
              .||:               .|..||               |:.|| :|..|     .|..:.:
Yeast   146 TPPAESQDIFRLKGKYPVDKENEGEQKNGSSNKDENESTFKFILFAN-KQTAFLLSDLDGGKLQL 209

  Fly  1504 HFL---------------------------------------PQ-QNADTWGASTQGSMRPRVVK 1528
            .||                                       || :.||...:|...|:..::.|
Yeast   210 AFLRSNLAQSLPINATMITRSYKYSSSATTKQTSTSFKAAKTPQTEVADGSNSSKSRSIETKLEK 274

  Fly  1529 R-----DLDDF---------------------------------------TIEQGES-------- 1541
            :     :|.||                                       .||.|::
Yeast   275 KVSNLFNLSDFLQLFNGNASKDQDDAQSLEKQMETDYNNADNSQGANASSKIEDGKNSGASDRQI 339

  Fly  1542 ----QRVDHLLFMVHGIGSACDLKMRSVEEVVDDFRVIAQQLVQSH----YKNSTDMGLVG---- 1594
                :.||:|:..|||||.....|.    |.|:....:  .|::|:    |.||..:..:.
Yeast   340 RSNRRDVDNLILCVHGIGQTLGKKY----EYVNFAHTV--NLLRSNMKKIYNNSEKLQSLNTAPD 398

  Fly  1595 -----RVEVLPISWHGHLHSEELGIDEK-----------LKSITLESIPRLRNFTNDTLLDVLFY 1643
                 .|:||||:|.   ||.....|.|           |..:|:..:..||....|.|||:|.|
Yeast   399 YKSNCNVQVLPITWR---HSISFQTDAKEENIENPDLPTLSQVTVNGVLPLRKLLADGLLDILLY 460

  Fly  1644 TSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCHQEPLKESEEENK 1708
            ..|.|...|:..|...||..|..::..:|||:|.|.|.||||||:||||:
Yeast   461 VEPYYQDMILQQVTSQLNKTYRIFKEFNPEFDGKVHLVGHSLGSMILFDI--------------- 510

  Fly  1709 ENPDQLPQKQSSQKVQLPTSDPLPKQVSYAMGPEGTGQPVITYTQLIFHPKKFFALGSPIGMFVT 1773
                                  |.||..|               :|.|.....|.:|||||:...
Yeast   511 ----------------------LSKQKKY---------------ELEFQVDNLFFIGSPIGLLKL 538

  Fly  1774 IRGIDKLG------------LDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHK 1826
            |:. .|:|            |....|.|...||::|..||::||:|.||:.:|.......:||..
Yeast   539 IQR-TKIGDRPEFPNDLERKLTVQRPQCKDIYNVYHVCDPISYRMEPLVSKEMAHYEQTYLPHCS 602

  Fly  1827 GRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQ 1891
            ..    ..|...:...|.:|.:....|.:..|.|          ||.:.|..|.:.|:..::.
Yeast   603 EA----YGLTSKVLEFGENIWKDLPGTDENNLQS----------KKTSPEKKEVKLSENLTRM-- 651

  Fly  1892 KQTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDFPLGKLNDSKRVDYVLQEAPLEFINEY 1956
                                                    |..||.:.|:||.:..:.||.  ::
Yeast   652 ----------------------------------------LTGLNYTGRLDYAMSPSLLEV--DF 674

  Fly  1957 IFALSSHVCYWGSEDTILFVMKEI 1980
            |.|:.|||.|:...|...|::|||
Yeast   675 ISAIKSHVSYFEEPDIAAFILKEI 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	WWE	1377..1446	CDD:280915	21/83 (25%)
PAPLA1	NP_609185.1	DDHD	1758..1981	CDD:280937	55/235 (23%)
DDL1	NP_014665.1	DDHD	522..699	CDD:397132	55/236 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346312
Domainoid	1	1.000	54	1.000	Domainoid score	I2792
eggNOG	1	0.900	-	-		E1_KOG2308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99995
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23509
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1772
SonicParanoid	1	1.000	-	-		X662
TreeFam	1	0.960	-	-
	9	8.830