DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAPLA1 and FIG2

DIOPT Version :9

Sequence 1:	NP_609185.1	Gene:	PAPLA1 / 34109	FlyBaseID:	FBgn0031990	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_010013.2	Gene:	FIG2 / 850451	SGDID:	S000000685	Length:	1609	Species:	Saccharomyces cerevisiae

Alignment Length:	1596	Identity:	309/1596 - (19%)
Similarity:	513/1596 - (32%)	Gaps:	438/1596 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NNNANQTRVVK--NPL--------LSASVTGLSFDDFPNKPQLLPAAPPVVHATPPAAPVLIAGI 68
            :.|:|||.::.  .||        ||:::...:.|      |.....|.:|.||....|.|
Yeast   227 SKNSNQTSLLSPLEPLSSSSGDLILSSTIQATTND------QTSKTIPTLVDATSSLPPTL---- 281

  Fly    69 LNREPKSLVTVGQPS----------------------SID----------DSEALDEINLNTSSE 101
              |......|.|..|                      |||          .|..|..:|..:.||
Yeast   282 --RSSSMAPTSGSDSISHNFTSPPSKTSGNYDVLTSNSIDPSLFTTTSEYSSTQLSSLNRASKSE 344

  Fly   102 --DSVGAGGSSPYLGAGDQNANPLLEPPTEAGNDSLLSQAASSFTALPAVASNVFSTFSKRIY-- 162
              :...:..|:|:   |..:|..|::|.:..|:      .||||.   .:::..|||.....|
Yeast   345 TVNFTASIASTPF---GTDSATSLIDPISSVGS------TASSFV---GISTANFSTQGNSNYVP 397

  Fly   163 ----AGSRETSEEPKLDIQPSYIQQASYV--------QPVAPVPAPFYAAPPAAANEVVAPEPPK 215
                :||.:..:.....:.   :.|.::|        ..|....:|.|.:......:.|..|...
Yeast   398 ESTASGSSQYQDWSSSSLP---LSQTTWVVINTTNTQGSVTSTTSPAYVSTATKTVDGVITEYVT 459

  Fly   216 FYAPTEVPPPNVGVPAPPPTSGNPNTYRFTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQAAPS- 279
            :...|:.....:||.:  ..|..|....|:....       ||..|...|....||::..:..|
Yeast   460 WCPLTQTKSQAIGVSS--SISSVPQASSFSGSSI-------LSSNSSTLAASNNVPESTASGSSQ 515

  Fly   280 ---FQTPPYP-PQLTY------------AANPAPFDISAQPAAI-----------PAEERKSGG- 316
               :.:...| .|.|:            .:..:|..:|.....:           |..:.||..
Yeast   516 YQDWSSSSLPLSQTTWVVINTTNTQGSVTSTTSPAYVSTATKTVDGVITEYVTWCPLTQTKSQAI 580

  Fly   317 GLFSLT-----SLVPTGVLQNITGI----VQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTN 372
            |:.|.|     :..|:.:|  ..||    :..||.:.:|..:|:         :.|.|.......
Yeast   581 GISSSTISATQTSKPSSIL--TLGISTLQLSDATFKGTETINTH---------LMTESTSITEPT 634

  Fly   373 LFGGPNSTFPPGGNYF-------------VPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAA 424
            .|.|.:.:|     |.             .|....|..||..:...:|  .|...:..|....:.
Yeast   635 YFSGTSDSF-----YLCTSEVNLASSLSSYPNFSSSEGSTATITNSTV--TFGSTSKYPSTSVSN 692

  Fly   425 PPAVGAFFTSAAPSVTPSVFTPGTVPPLAP-QPFQSATVNQSALPPNNPPTASAVGELFVPAPTT 488
            |.......:|:..|:|.  ||..:...:|. ......:.|:...........|.:..|.:...||
Yeast   693 PTEASQHVSSSVNSLTD--FTSNSTETIAVISNIHKTSSNKDYSLTTTQLKTSGMQTLVLSTVTT 755

  Fly   489 IAQGTS-------PA--VPFVDTQAVPTIPLTV---PPGNPPPTSTLGGFFTTGEVAPVVAPFGT 541
            ...|.:       ||  :.:..:.:..|:.||.   ......|| .:.....|....|:::...:
Yeast   756 TVNGAATEYTTWCPASSIAYTTSISYKTLVLTTEVCSHSECTPT-VITSVTATSSTIPLLSTSSS 819

  Fly   542 QASPATQSAGFFNP--GEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPG 604
            ....:|.|.|..||  .||..|..::   .|...||:..........|.|    ..:|..:.:..
Yeast   820 TVLSSTVSEGAKNPAASEVTINTQVS---ATSEATSTSTQVSATSATATA----SESSTTSQVST 877

  Fly   605 AAAPPPAAGQASYRL-------QKGTRLYKSPLTPQET---ATSSGFAAPLPPTSVTPAIFNPFG 659
            |:......|..::..       ...|.:..:.:..::|   :|.....:...||.:|..:.:. |
Yeast   878 ASETISTLGTQNFTTTGSLLFPALSTEMINTTVVSRKTLIISTEVCSHSKCVPTVITEVVTSK-G 941

  Fly   660 APAPGSFNSVGHLEG-----QSSQGVPFFTPPVQNPPGQVAAPTVAVP---QSAPIAPPPGTSST 716
            .|:.|..:.....|.     .|.|.|...|....|   .:..|||...   :|.|.  |..||||
Yeast   942 TPSNGHSSQTLQTEAVEVTLSSHQTVTMSTEVCSN---SICTPTVITSVQMRSTPF--PYLTSST 1001

  Fly   717 SVAPPLTASIANPPPTSGFAS--VPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTT 779
            |     ::|:|:...:|..||  :..|:..| .|.|:.|.:.:...   ||.:||..|....:|.
Yeast  1002 S-----SSSLASTKKSSLEASSEMSTFSVST-QSLPLAFTSSEKRS---TTSVSQWSNTVLTNTI 1057

  Fly   780 LE------GLVQGPAPTLSASQFFD-TPLPTGTQPENQVASVSSERENLVQEPISNQGIPFFAPP 837
            :.      ...:.|:.|.|...|.. ..||:.:.|.....|.::...|.::
Yeast  1058 MSSSSNVISTNEKPSSTTSPYNFSSGYSLPSSSTPSQYSLSTATTTINGIK-------------- 1108

  Fly   838 QTNIFT---PQLQQEFIAPAEDSKRSEIQEEFLSAPPQESNLS-TELREDTHTG----------- 887
              .::|   |..::..:|.:..|.||  .:.|:|:....|:|| |.::....|.
Yeast  1109 --TVYTTWCPLAEKSTVAASSQSSRS--VDRFVSSSKPSSSLSQTSIQYTLSTATTTISGLKTVY 1169

  Fly   888 ----PPVIEPVLEETPASSSESSV--PPASKVDQEDIVYPEPSAPVEQEIP---LFVPVPGLPGL 943
                |...:..|..|..:||.:.|  ..||......|   ..|...|.|..   |...|......
Yeast  1170 TTWCPLTSKSTLGATTQTSSTAKVRITSASSATSTSI---SLSTSTESESSSGYLSKGVCSGTEC 1231

  Fly   944 SQDIPLYPPPPTG--------STTASSIFAAPPVASSAPLFVPVPGPPSVSSLFSPSQVDSTS-- 998
            :||:|.....|..        ||::||.|:....::.......||..||.||: |.|...|||
Yeast  1232 TQDVPTQSSSPASTLAYSPSVSTSSSSSFSTTTASTLTSTHTSVPLLPSSSSI-SASSPSSTSLL 1295

  Fly   999 SLFAPPPTSANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATN 1063
            |...|.|...::|:.|....::||..|:::|.::.|...:.|.:|:.|:..   |..||
Yeast  1296 STSLPSPAFTSSTLPTATAVSSSTFIASSLPLSSKSSLSLSPVSSSILMSQ---FSSSS------ 1351

  Fly  1064 LFQGNTETQTVFSPFAQTKATPLVQETKPELVPPPIGFFAPKSESEVLSQPPLAPSPLQSFFS-- 1126
                                                     .|.|.:.|.|.|:.||.....|
Yeast  1352 -----------------------------------------SSSSSLASLPSLSISPTVDTVSVL 1375

  Fly  1127 ---TAPETATTTDFNFFGSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVSNIATSAIGFDLLNQ 1188
               |:..|.|.||                              |..|..||.|...:...|:.:.
Yeast  1376 QPTTSIATLTCTD------------------------------SQCQQEVSTICNGSNCDDVTST 1410

  Fly  1189 TQQASSLVENSN-------QNSSVNSFDGYFGGPSASAAQTFANETT---------NALVAPAIN 1237
            .....|.|.::.       |.::.:|.|||    |...::|:.:..|         .|.....:|
Yeast  1411 ATTPPSTVTDTMTCTGSECQKTTSSSCDGY----SCKVSETYKSSATISACSGEGCQASATSELN 1471

  Fly  1238 CDPVNFFDQVPQ---TQSQIQQANEDQRIQNFFNNPPLQDQPAVPGELKYDIVHSGVAVKQLQER 1299
            ...|.....:..   |.:.::..:.:..|......|.........|||        :.:....:.
Yeast  1472 SQYVTMTSVITPSAITTTSVEVHSTESTISITTVKPVTYTSSDTNGEL--------ITITSSSQT 1528

  Fly  1300 SQTPVSNLVEPPSSACSEFSTLAPAPTQTDRQSGDDLLQQHLGELPEDILRELRMASASSEKGQV 1364
            ....|:.::.....|.    |.||.||.|                   ...|.|::|:.     :
Yeast  1529 VIPSVTTIITRTKVAI----TSAPKPTTT-------------------TYVEQRLSSSG-----I 1565

  Fly  1365 ATPPVAIPYS-----PVVAHWFYKRSVDTKFIWTPF 1395
            ||..||...|     |:|:.:....|   ||:.:.|
Yeast  1566 ATSFVAAASSTWITTPIVSTYAGSAS---KFLCSKF 1598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	WWE	1377..1446	CDD:280915	5/19 (26%)
PAPLA1	NP_609185.1	DDHD	1758..1981	CDD:280937
FIG2	NP_010013.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000